Effects of Driving Frequency and Voltage on the Performances of Vibrating Mesh Nebulizers

Moon, Sang-Hyub; Chang, Kuo‐Hsuan; Park, Hyun Mok; Park, Bong Joo; Yoo, Sun Kook; Nam, Ki Chang

doi:10.3390/app11031296

Cited by 5 publications

(5 citation statements)

References 25 publications

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“…This viscosity is similar to that of a 13% glycerol solution [ 29 ]. It is known that a change in resonance frequency of the PZT is necessary to adapt to the change in impedance due the temperature of PZT and solution viscosity [ 30 , 31 ]. Impedance of the PZT increased as IgG concentration increased in both IgG temperature conditions Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Cold_S and RTequ_S were used as controls in cold IgG (a; Cold_IgG) and cold IgG equilibrated at RT for 15 min (b; RTequ_IgG), respectively. All data are presented as mean ± SD value viscosity [30,31]. Impedance of the PZT increased as IgG concentration increased in both IgG temperature conditions Fig.…”

Section: Effects Of Low Temperature and The Viscosity Of Igg On The I...mentioning

confidence: 99%

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Aerosolization Performance of Immunoglobulin G by Jet and Mesh Nebulizers

2023

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Recently, many preclinical and clinical studies have been conducted on the delivery of therapeutic antibodies to the lungs using nebulizers, but standard treatment guidelines have not yet been established. Our objective was to compare nebulization performance according to the low temperature and concentration of immunoglobulin G (IgG) solutions in different types of nebulizers, and to evaluate the stability of IgG aerosols and the amount delivered to the lungs. The output rate of the mesh nebulizers decreased according to the low temperature and high concentration of IgG solution, whereas the jet nebulizer was unaffected by the temperature and concentration of IgG. An impedance change of the piezoelectric vibrating element in the mesh nebulizers was observed because of the lower temperature and higher viscosity of IgG solution. This affected the resonance frequency of the piezoelectric element and lowered the output rate of the mesh nebulizers. Aggregation assays using a fluorescent probe revealed aggregates in IgG aerosols from all nebulizers. The delivered dose of IgG to the lungs in mice was highest at 95 ng/mL in the jet nebulizer with the smallest droplet size. Evaluation of the performance of IgG solution delivered to the lungs by three types of nebulizers could provide valuable parameter information for determination on dose of therapeutic antibody by nebulizers. Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Section: Effects Of Low Temperature and The Viscosity Of Igg On The I...mentioning

confidence: 99%

Aerosolization Performance of Immunoglobulin G by Jet and Mesh Nebulizers

2023

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“…Samples were aerosolized using a piezo vibrating mesh nebulizer (1100 holes, 6 um of diameter, and 110 kHz of vibrating frequency) [ 38 ] placed inside a chamber (generation chamber) and controlled by a nebulizer control board. The OPC withdrew an aerosol sample (for a duration of 1 min) from the generation chamber using its integrated fan.…”

Section: Methodsmentioning

confidence: 99%

“…Figure 2 reports the scheme of the measurement setup used to perform all tests presented (Figure S1 in the Supplementary Materials shows a photograph of the setup). Samples were aerosolized using a piezo vibrating mesh nebulizer (1100 holes, 6 um of diameter, and 110 kHz of vibrating frequency) [38] placed inside a chamber (generation chamber) and controlled by a nebulizer control board. The OPC withdrew an aerosol sample (for a duration of 1 min) from the generation chamber using its integrated fan.…”

Section: Measurement Setupmentioning

confidence: 99%

Improving Aerosol Characterization Using an Optical Particle Counter Coupled with a Quartz Crystal Microbalance with an Integrated Microheater

Zampetti,

Mancuso,

Capocecera

et al. 2024

Sensors

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Aerosols, as well as suspended particulate matter, impact atmospheric pollution, the climate, and human health, directly or indirectly. Particle size, chemical composition, and other aerosol characteristics are determinant factors for atmospheric pollution dynamics and more. In the last decade, low-cost devices have been widely used in instrumentation to measure aerosols. However, they present some issues, such as the problem of discriminating whether the aerosol is composed of liquid particles or solid. This issue could lead to errors in the estimation of mass concentration in monitoring environments where there is fog. In this study, we investigate the use of an optical particle counter (OPC) coupled to a quartz crystal microbalance with an integrated microheater (H-QCM) to enhance measurement performances. The H-QCM was used not only to measure the collected mass on its surface but also, by using the integrated microheater, it was able to heat the collected mass by performing heating cycles. In particular, we tested the developed system with aerosolized saline solutions of sodium chloride (NaCl), with three decreasing concentrations of salt and three electronic cigarette solutions (e-liquid), with different concentrations of propylene glycol and glycerin mixtures. The results showed that the OPC coherently counted the salt dilution effects, and the H-QCM output confirmed the presence of liquid and solid particles in the aerosols. In the case of e-liquid aerosols, the OPC counted the particles, and the HQCM output highlighted that in the aerosol, there were no solid particles but a liquid phase only. These findings contribute to the refinement of aerosol measurement methodologies by low-cost sensors, fostering a more comprehensive understanding.

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“…Metallic VMA are extensively being researched for atomization rate 22 , nozzle taper angle 23 , and effect of operating parameters on its performance 24 . However, there is limited investigation on droplet size distribution and most research with VMA devices only investigate atomization of water.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Droplet Size Distribution for Vibrating Mesh Atomizer

Sharma¹,

Quazi²,

Vazquez³

et al. 2021

Preprint

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Vibrating mesh atomizers (VMA) are increasing in demand for various aerosol applications due to their ability to generate uniformly sized droplets. Currently there are two types of VMA (commercial metallic membranes and silicon based). High Uniformity and control of small droplet size are the basic requirements for many aerosol applications, for which ultrasonic or VMA are employed. However, there is limited research on understanding the droplet size distribution of different types of atomizers. In this study three aerosol generators were investigated: Ultrasonic, metallic VMA, and MEMS-based silicon VMA. The primary objective was to compare these devices on droplet size distribution and mechanism of action. A systematic study to compare the performance of the two VMA was investigated based on droplet distribution, volumetric median diameter (VMD) using liquids with different physiochemical properties. Size distribution of the droplet produced by the metallic VMA was twice the span compared to silicon VMA for fluids with viscosity <2cP. The metallic VMA also resulted in an increase in VMD as the viscosity increased, whereas the Si VMA did not see a significant increase in VMD. The silicon-based VMA demonstrated a 4-15x increase in fine particle fraction control compared to metallic VMA. The results demonstrate that silicon based VMA has narrower droplet distribution with more uniform droplet size and lower span compared to metallic VMA.

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Effects of Driving Frequency and Voltage on the Performances of Vibrating Mesh Nebulizers

Cited by 5 publications

References 25 publications

Aerosolization Performance of Immunoglobulin G by Jet and Mesh Nebulizers

Aerosolization Performance of Immunoglobulin G by Jet and Mesh Nebulizers

Improving Aerosol Characterization Using an Optical Particle Counter Coupled with a Quartz Crystal Microbalance with an Integrated Microheater

Investigation of Droplet Size Distribution for Vibrating Mesh Atomizer

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