Effects of dried licorice extract with low-calorie diet on lipid profile and atherogenic indices in overweight and obese subjects: A randomized controlled clinical trial

Mirtaheri, Elham; Namazi, Nazli; Alizadeh, Mohammad; Sargheini, Nafiseh; Saadat, Karimi

doi:10.1016/j.eujim.2015.03.006

Cited by 16 publications

(13 citation statements)

References 25 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glycyrrhiza glabra or licorice root was investigated in two studies (n = 149), one as a single‐herb product over 8 weeks and one in a Japanese medicine over 24 weeks . Both studies reported an appropriate method for random sequence generation, thus were rated low risk in this criterion.…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of herbal medicines for weight loss: A systematic review and meta‐analysis of randomized controlled trials

Maunder

Bessell

Lauche

et al. 2020

Diabetes Obesity Metabolism

View full text Add to dashboard Cite

Aim: To update the available evidence on the efficacy and safety of complementary medicines to assist in weight loss by conducting a systematic review and metaanalysis of herbal medicines for weight loss.Methods: Four electronic databases (Medline, Embase, CINAHL and Web of Science) were searched from inception until August 2018. A total of 54 randomized placebocontrolled trials of healthy overweight or obese adults were identified. Meta-analyses were conducted for herbal medicines with ≥4 studies available. Weight differences of ≥2.5 kg were considered clinically significant.Results: As a single agent, only Phaseolus vulgaris resulted in a statistically significant weight loss compared to placebo, although this was not considered clinically significant. No effect was seen for Camellia sinensis or Garcinia cambogia. Statistically, but not clinically, significant differences were observed for combination preparations containing C. sinensis, P. vulgaris or Ephedra sinica. Of the herbal medicines trialled in ≤3 randomized controlled trials, statistically and clinically significant weight loss compared to placebo was reported for Irvingia gabonensis, Cissus quadrangularis, and Sphaeranthus indicus combined with Garcinia mangostana, among others, but these findings should be interpreted cautiously because of the small number of studies, generally poor methodological quality, and poor reporting of the herbal medicine interventions. Most herbal medicines appeared safe for consumption over the short duration of the studies (commonly ≤12 weeks). Some warrant further investigation to determine effect size, dosage and long-term safety.Conclusion: There is currently insufficient evidence to recommend any of the herbal medicines for weight loss included in the present review. K E Y W O R D Sherbal medicines, meta-analysis, systematic review, weight loss

show abstract

Section: Resultsmentioning

confidence: 99%

Effectiveness of herbal medicines for weight loss: A systematic review and meta‐analysis of randomized controlled trials

Maunder

Bessell

Lauche

et al. 2020

Diabetes Obesity Metabolism

View full text Add to dashboard Cite

show abstract

“…Especially, in the past decades, an increase in dyslipidemia has been observed, following the increased prevalence of overweight and obesity. 2,3 Dyslipidemia is a major risk factor for developing CVD, which is an important public health concern in both developed and developing countries. 4 Recently, there has been a greater focus on medicinal plants or functional foods to prevent chronic diseases such as obesity, dyslipidemia and atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Korean traditional Chungkookjang improves body composition, lipid profiles and atherogenic indices in overweight/obese subjects: a double-blind, randomized, crossover, placebo-controlled clinical trial

et al. 2016

Eur J Clin Nutr

View full text Add to dashboard Cite

show abstract

“…Assessment of dietary intake and physical activity levels were measured as explained in our previous study. 12 …”

Section: Methodsmentioning

confidence: 99%

“…It contains various components with pharmacological properties, including glycyrrhizin, glabridin, flavonoids, beta-Glycyhrritinic acid, chalcones, isoflavones and triterpenoid saponins. 12 , 13 Licorice root is frequently used in traditional medicine, particularly for gastric and duodenal ulcers, dyspepsia and allergenic reactions. Human and animal models have not demonstrated any toxic or serious side effects of licorice consumption.…”

Section: Introductionmentioning

confidence: 99%

Changes of Insulin Resistance and Adipokines Following Supplementation with Glycyrrhiza Glabra L. Extract in Combination with a Low-Calorie Diet in Overweight and Obese Subjects: a Randomized Double Blind Clinical Trial

et al. 2018

Self Cite

View full text Add to dashboard Cite

Purpose: Adipose tissue is a highly active endocrine organ which plays a key role in energy homeostasis. The aim of this study was to determine the effects of dried licorice extract along with a calorie restricted diet on body composition, insulin resistance and adipokines in overweight and obese subjects.Methods: Sixty-four overweight and obese volunteers (27 men, 37 women) were recruited into this double-blind, placebo-controlled, randomized, clinical trial. Participants were randomly allocated to the Licorice (n=32) or the placebo group (n=32), and each group received a low-calorie diet with either 1.5 g/day of Licorice extract or placebo for 8 weeks. Biochemical parameters, anthropometric indices, body composition and dietary intake were measured at baseline and at the end of the study.Results: A total of 58 subjects completed the trial. No side effects were observed following licorice supplementation. At the end of the study, waist circumference, fat mass, serum levels of vaspin, zinc-α2 glycoprotein, insulin and HOMA-IR were significantly decreased in the intervention group, but only the reduction in serum vaspin levels in the licorice group was significant when compared to the placebo group (p<0.01).Conclusion: Supplementation with dried licorice extract plus a low-calorie diet can increase vaspin levels in obese subjects. However, the anti-obesity effects of the intervention were not stronger than a low-calorie diet alone in the management of obesity.

show abstract

Effects of dried licorice extract with low-calorie diet on lipid profile and atherogenic indices in overweight and obese subjects: A randomized controlled clinical trial

Cited by 16 publications

References 25 publications

Effectiveness of herbal medicines for weight loss: A systematic review and meta‐analysis of randomized controlled trials

Effectiveness of herbal medicines for weight loss: A systematic review and meta‐analysis of randomized controlled trials

Korean traditional Chungkookjang improves body composition, lipid profiles and atherogenic indices in overweight/obese subjects: a double-blind, randomized, crossover, placebo-controlled clinical trial

Changes of Insulin Resistance and Adipokines Following Supplementation with Glycyrrhiza Glabra L. Extract in Combination with a Low-Calorie Diet in Overweight and Obese Subjects: a Randomized Double Blind Clinical Trial

Contact Info

Product

Resources

About