Effects of dried Citrus unshiu peels on gastrointestinal motility in rodents

Abstract

Aqueous extracts of the dried mature (ANP-W) and immature Citrus unshiu peels (CUP-W) have been used as a traditional folk medicine for the treatment of gastrointestinal (GI) motility disorders in Korea. In the present study, neither ANP-W nor CUP-W exhibited significant toxicity even at an oral dose of 5 g/kg to mice. The effects of ANP-W and CUP-W on GI motor function were investigated by measuring the intestinal transit rate (ITR) of Evans blue in normal mice and rats with experimental GI motility dysfunctions (GMDs). In normal mice, the ITR was significantly increased by ANP-W (0.1-1 g/kg) in a dose dependent manner, whereas CUP-W elicited no significant change. GMD was induced by appropriate surgery or an intraperitoneal injection of acetic acid to the rats. The ITR in the GMD rats was significantly retarded compared to that in normal rats. However, the retardation was significantly inhibited by ANP-W (0.1-1 g/kg) in a dose dependent manner. The above results suggest that ANP-W has the potential for development as a prokinetic agent that may prevent or alleviate GMD in human patients.

Quercetin Inhibits Pacemaker Potentials via Nitric Oxide/cGMP-Dependent Activation and TRPM7/ANO1 Channels in Cultured Interstitial Cells of Cajal from Mouse Small Intestine

“…PF is one of the most popular traditional folk medicines in Korea as is derived from the Rutaceae fruits. It has been shown to have unique and potent prokinetic activities in normal rodents and in rodent models of GI motility dysfunction (GMD) [58,59]. PF significantly increased ITR (%) at a dose of 1 g/kg (by 75.1 ± 1.8 %, p<0.01), which is consistent with previous reports [60,61].…”

Effects of Schisandra chinensis extract on gastrointestinal motility in mice

“…Furthermore, citrus unshiu peel has been reported to function as a gastroprokinetic agent. In normal mice, ITR was significantly increased by citrus unshiu peels and reductions in ITR associated with GI motility dysfunction were significantly inhibited (Lyu and Lee, 2013). In the present study, we investigated the in vivo motility effects of SC extract against the backgrounds of normal and dysfunctional GI motility in mice.…”

“…(PF) was obtained as previously described . PF is one of the most popular traditional folk medicines in Korea originated from Rutaceae fruits, and is known to have unique, potent prokinetic activity in normal and rodents with GI motility dysfunction (GMD) Lyu and Lee, 2013).…”

“…PIA was induced by an intraperitoneal (i.p.) injection of acetic acid (0.6%, w/v, in saline) at a dose of 10 ml/kg, as previously described (Friese et al, 1997;Lee et al, 2005b;Lyu and Lee, 2013;Pairet and Ruckebusch, 1989;Rivière et al, 1993). After injecting acetic acid, mice were placed in individual cages and allowed to recover for 30 min.…”

Modified Da Chengqi granules improvement in immune function in early severe acute pancreatitis patients

“…Snakegourd root, a main component of snakegourd fruit, has immunoregulatory function that helps resist hypoxia, activates immunocytes, and increases the ability to defend against infections Xu et al, 2010;Yan et al, 2012). Immature orange fruit relieves constipation, displays anti-inflammatory and antioxidant effects (Menichini et al, 2011;Kang et al, 2013;Yu et al, 2013), promotes gut hormone secretion, and improves gastrointestinal motility (Wu et al, 2011;Lyu and Lee, 2013). Rhubarb and goldthread clear away heat-evil and expel superficial evils, and thus have a positive therapeutic impact on pancreatitis (Wu et al, 2000;Wang et al, 2007;Li et al, 2009).…”