Effects of Dried Bonito (<i>Katsuobushi</i>) and Captopril, an Angiotensin I-Converting Enzyme Inhibitor, on Rat Isolated Aorta: A Possible Mechanism of Antihypertensive Action

Kouno, Kazuyo; Hirano, Shin‐ichi; Kuboki, Hiroshi; Kasai, Midori; Hatae, Keiko

doi:10.1271/bbb.69.911

Cited by 46 publications

(37 citation statements)

References 10 publications

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“…Namely, DBB was found to affect vascular smooth muscle contractions through the activation of α-adrenergic receptors rather than through the entry of extracellular calcium ions using rat thoracic aortas without endothelia. 15) Ingestion of DBB was possibly involved in direct action on vascular smooth muscle, expanding the vascular diameter, and thereby increasing blood flow.…”

Section: Discussionmentioning

confidence: 99%

Consumption of Dried-bonito Broth Acutely Increases Peripheral Blood Flow in Humans

Nozawa

Kuroda

Noguchi

2007

JOURNAL OF HEALTH SCIENCE

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We investigated the acute effect of a single dose of dried-bonito broth (DBB) on peripheral blood flow using a laser Doppler blood flow meter. In a randomized, double-blind, crossover, placebo-controlled study, 19 healthy female subjects ingested DBB (4900 mg) or placebo. The peripheral blood flow was measured before ingestion and at 5, 10, 15, 20, 25, 30, 45, and 60 min after ingestion of the test diet. Blood flow significantly increased after DBB ingestion, and the area under the blood flow-time curves calculated up to 60 min (AUC 0-60 ) for the ingestion with DBB was significantly higher than that for the placebo ingestion ( p < 0.001). Following consumption of lower dose of DBB (2450 mg), an increase in peripheral blood flow was observed and that the AUC 0-60 after subjects consumed DBB was significantly higher than that after they consumed the placebo ( p < 0.01). The mean AUC 0-60 for the treatment with 4900 mg DBB was about 2 times that for 2450 mg DBB, suggesting that an orally administered single dose of DBB might have an acute dose-dependent effect on peripheral blood flow.

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Section: Discussionmentioning

confidence: 99%

Consumption of Dried-bonito Broth Acutely Increases Peripheral Blood Flow in Humans

Nozawa

Kuroda

Noguchi

2007

JOURNAL OF HEALTH SCIENCE

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“…The functions of these substances are not similar to those of NA of non-protein amino acid: NA suppresses the activity of ACE in the aortic vascular wall in a concentration-dependent manner, and it shows influence on the activation of ␣-adrenergic receptors. On the other hand, captopril, an ACE inhibitor, suppresses endogenous norepinephrine-induced vasoconstriction (14). On a similar line of thought, the possibility that NA may regulate blood pressure by these 2 mechanisms was suggested.…”

Section: Discussionmentioning

confidence: 96%

“…Various components of food origin have direct influence on vascular smooth muscle contraction, including peptides isolated from sardine muscle ( 13 ); dried bonito ( 14 ) and seaweed ( 15 ); radish leaf extract ( 16 ); a component of garlic ( 17); and tannin extract from cinnamonomi cortex (18). The functions of these substances are not similar to those of NA of non-protein amino acid: NA suppresses the activity of ACE in the aortic vascular wall in a concentration-dependent manner, and it shows influence on the activation of ␣-adrenergic receptors.…”

Section: Discussionmentioning

confidence: 99%

Studies on the Mechanism of Antihypertensive Action by Nicotianamine

Hayashi

Kimoto

2010

J Nutr Sci Vitaminol

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Summary Nicotianamine (NA), which is obtained from vegetables, lowers blood pressure through the renin-angiotensin system, and we clarified that NA preferentially inhibits the activity of angiotensin I-converting enzyme (ACE)-a zinc-containing enzyme. In this study, we elucidated the mechanism of antihypertensive action of NA through the Magnus method by using rat aortic blood vessels. Angiotensin I-induced contractions were inhibited by NA in a concentration-dependant manner. Because NA did not inhibit angiotensin II-induced contractions, it was believed that NA inhibited ACE activity in vascular smooth muscles. NA did not affect KCl-induced contractions, but it affected norepinephrine-induced contractions to a small extent. NA exerted similar effects on endothelium-denuded and endotheliumintact blood vessels. Therefore, the antihypertensive action of NA did not play a role in the opening of voltage-dependent calcium channels, but this effect influenced vasoconstriction by the activation of ␣ -adrenergic receptors. These results suggest that after absorption from the intestinal tract, NA may exert antihypertensive effects via 2 mechanisms: direct inhibition of ACE in vascular smooth muscle and activation of ␣ -adrenergic receptors.

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“…Kouno et al (16) reported that BE inhibited the contractions induced by noradrenaline in a concentration-dependent manner in the rat thoracic aorta. Nozawa et al (22) reported that blood flow increased, but that heart rate did not change after the ingestion of BE in a human study, surmising that the mechanism by which blood flow increases after the ingestion of BE may relate to the vasodilatory effects of BE.…”

Section: References Thecholamine Releasementioning

confidence: 99%

Ingestion of bonito extract ameliorates peripheral blood flow in mice loaded from over crowding stress

et al. 2009

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Bonito extract (BE) has been shown to improve various fatigue-related symptoms. The possibility that the improvement of blood flow contributes to the improvement of fatigue-related symptoms has been reported. However, even though BE has been found to increase peripheral blood flow in humans, an understanding of its mechanisms has remained elusive. The purpose of the present study is to construct an animal model system with which the blood flow-increasing effects of BE can be examined. Using mice loaded with crowding stress, an attempt was made to reproduce the increases in peripheral blood flow observed in humans after a single administration of BE. In this study, the crowded-condition mice (20 mice/cage) showed significantly increased catecholamine levels (noradrenaline, adrenaline, and dopamine) in their circulating blood and a decreased rate of skin blood perfusion in comparison with the normal-condition mice (6 mice/cage). The rate of skin blood perfusion was significantly increased by BE in the crowded-condition mice in comparison with the controls, but not influenced by BE in the normal-condition mice. This suggests that BE expands the vascular diameter by affecting the constriction of vessels induced by catecholamines.Bonito extract (BE) is commonly used as soup stock in Japan. Bonito (skipjack tuna, Katsuwonus pelamis) is the name given to various species of medium-sized, predatory fish of the genus Sarda in the mackerel family and is known as katsuo in Japan. It is smoked and dried to make dried bonito, katsuobushi, which is an important ingredient in dashi (Japanese soup stock). Dried BE (katsuobushi-dashi) has a specific flavor and is used extensively in Japanese cuisine (7, 15) and traditional foods in Japan; for instance, in kachu-yu (a soup containing dried bonito and soy paste) in Okinawa and in cha-bushi (a soup containing dried bonito, soy paste, and green tea) in Kagoshima. Furthermore, it is consumed as a nutritional supplement that is believed to promote recovery from fatigue. We have previously demonstrated the anti-fatigue effects of BE in both animals and humans. Animal studies have shown that the administration of BE aids recovery from physical fatigue (11,18,19), and in humans the consumption of BE improves mental fatigue (13, 17), visual fatigue (8, 9), and shoulder stiffness (21). To examine the factors that contribute to the recovery from fatigue brought about by ingestion of BE, the effects of BE on the peripheral circulation were studied. Skin blood flow in humans is increased by the ingestion of BE, reaching a maximum 25-30 min after the ingestion (22). In another study, it became clear that the daily ingestion of BE for two weeks induces increases in skin blood flow at rest (20). Furthermore, the changes in blood flow that occurred after the ingestion of BE were significantly correlated with changes in fatigue scores on the profile of mood states (POMS) questionnaire. From these results, it is probable that the improvement of blood flow contributes to some degree to

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Effects of Dried Bonito (Katsuobushi) and Captopril, an Angiotensin I-Converting Enzyme Inhibitor, on Rat Isolated Aorta: A Possible Mechanism of Antihypertensive Action

Cited by 46 publications

References 10 publications

Consumption of Dried-bonito Broth Acutely Increases Peripheral Blood Flow in Humans

Consumption of Dried-bonito Broth Acutely Increases Peripheral Blood Flow in Humans

Studies on the Mechanism of Antihypertensive Action by Nicotianamine

Ingestion of bonito extract ameliorates peripheral blood flow in mice loaded from over crowding stress

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