Effects of Doxycycline in Swiss Mice Predictive Models of Schizophrenia

Issy, Ana Carolina; Pedrazzi, João Francisco Cordeiro; Oosten, Anna Beatriz Saito van; Checheto, Thiago; Silva, Rafaela R; Noël, François; Del‐Bel, Elaine

doi:10.1007/s12640-020-00268-z

Cited by 6 publications

(9 citation statements)

References 64 publications

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“…The BLISTER trial demonstrated doxycycline 200 mg daily effectively controls blisters with a safer profile compared to oral prednisolone 14 . Furthermore, an experimental study on mice showed doxycycline has antipsychotic‐like effects and could be a safe adjuvant treatment option in schizophrenia 15 . The underlying mechanisms are unclear, but doxycycline appears to work differently to conventional antipsychotics, which target dopamine and 5‐HT receptors 15 …”

Section: Discussionmentioning

confidence: 99%

“… 15 The underlying mechanisms are unclear, but doxycycline appears to work differently to conventional antipsychotics, which target dopamine and 5‐HT receptors. 15 …”

Section: Discussionmentioning

confidence: 99%

“…15 The underlying mechanisms are unclear, but doxycycline appears to work differently to conventional antipsychotics, which target dopamine and 5-HT receptors. 15 Patients with BP also show an increased prevalence of diabetes. 7 Bullous pemphigoid is mostly associated with DPP4-inhibitors, which increase the risk of BP by two-fold 16 and the highest risk is associated with vildagliptin.…”

Section: What Does This Study Add?mentioning

confidence: 99%

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Bullous pemphigoid in a patient with a neuropsychological disorder and a possible novel drug trigger: A case report and review of the literature

Dyson

Patel

Igali

et al. 2022

Skin Health and Disease

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A 59‐year‐old woman with schizoaffective disorder presented with an itchy, blistering generalised rash. One month prior, she had started empagliflozin, a sodium glucose transporter‐2 (SGLT‐2) inhibitor, used in type‐2‐diabetes. She was already established on paliperidone, an atypical antipsychotic, for 1 year. Serology at presentation was positive for anti‐pemphigoid antibodies. Histology demonstrated subepidermal blistering, perivascular inflammation and eosinophils. Direct immunofluorescence was characteristic of bullous pemphigoid (BP), with linear IgG and C3 at the basement membrane. Both empagliflozin and paliperidone were discontinued. However, the blisters persisted. Treatment included: topical Dermovate and Eumovate ointment for the body and face respectively, alongside oral doxycycline 200 mg and prednisolone 40 mg for a week (reducing by 5 mg/week over 8 weeks). Nevertheless, new blisters continued developing, hence dapsone 50 mg was introduced, with significant improvement. Increasingly, several neurological and psychiatric disorders have been linked with BP, complicating aetiology and management. The underlying mechanism for these associations is not fully understood. Bullous pemphigoid autoantigens BP180 and BP230 are expressed in the central nervous system and it is thought that neurodegeneration may expose antigens to the immune system, generating a cross‐reactive immune response. However, there also appears to be bidirectional causality between BP and neuropsychological conditions. Furthermore, as there was an association of empagliflozin initiation and BP onset, this further complicates the aetiology and presents a potential novel drug cause of BP. This case emphasises the neuropsychological issues associated with managing complex BP cases, a possible novel cause of drug‐induced BP and highlights the likelihood of these issues becoming increasingly prevalent for the future.

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Section: Discussionmentioning

confidence: 99%

“… 15 The underlying mechanisms are unclear, but doxycycline appears to work differently to conventional antipsychotics, which target dopamine and 5‐HT receptors. 15 …”

Section: Discussionmentioning

confidence: 99%

Section: What Does This Study Add?mentioning

confidence: 99%

See 1 more Smart Citation

Bullous pemphigoid in a patient with a neuropsychological disorder and a possible novel drug trigger: A case report and review of the literature

Dyson

Patel

Igali

et al. 2022

Skin Health and Disease

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“…Experiment 1 For evaluation of psychotic-like effects of dopaminergic drugs independent cohorts of 5-LO −/− and wild-type mice were acutely treated with both intraperitoneal amphetamine (10 mg/kg) or subcutaneous apomorphine (0.5 mg/kg) (Issy et al 2009(Issy et al , 2020 or with their respective controls (saline or distillated water). An additional group of 5-LO −/− mice received an intraperitoneal injection of glutamatergic antagonist MK801 (0.5 mg/kg; Issy et al 2018).…”

Section: Experimental Designmentioning

confidence: 99%

Differential dopamine-mediated effects in the 5-lipoxygenase deficient mice

Issy,

Pedrazzi,

Nascimento

et al. 2024

Preprint

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The role of 5-lipoxygenase/leukotrienes on the central nervous system has been considered in both physiological end pathological states. Investigating the interaction between 5-lipoxygenase/leukotrienes and the dopaminergic system may provide better understanding of dopamine-related pathologies. This study aimed to investigate motor and non-motor dopamine-related responses in 5-lipoxygenase/leukotrienes-deficient mice. Pharmacological challenges of the dopaminergic system included amphetamine, apomorphine and reserpine treatment along with their respective effects on prepulse inhibition (PPI) response, general motor activity, and oral involuntary movements. Reserpine-treated mice were also investigated for their striatal glial markers’ expression (GFAP and Iba-1). 5-lipoxygenase/leukotrienes-deficient mice exhibited increased spontaneous locomotor activity, including horizontal and vertical exploratory activity, and stereotyped-like behavior compared to wild-type mice. This condition was attenuated by acute apomorphine treatment. Despite the absence of altered basal responses in the PPI there was a significant and selective decreased in susceptibility in amphetamine-induced PPI disruption in 5-lipoxygenase/leukotrienes-deficient mice. However, there was an increased vulnerability to reserpine-induced involuntary movements. There was no alteration in the basal expression of striatal GFAP and Iba-1 positive cells in 5-lipoxygenase/leukotrienes-deficient mice compared to wild-type mice. Reserpine treatment induced a significant increase in GFAP immunoreactivity in wild-type mice but this effect was absent in the 5-lipoxygenase deficient mice. The percentage of activated microglia was found to be significantly increased in reserpine-treated wild-type mice. This effect was absent in the 5-lipoxygenase/leukotrienes-deficient mice. Our results support the conception of a unique dopaminergic pathway phenotype in 5-lipoxygenase/leukotrienes-deficient mice. These findings suggest that leukotrienes may interfere with the orchestration of dopamine-mediated responses.

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“…O desempenho prejudicado no PPI pode ser revertido através do tratamento com antipsicóticos como haloperidol, olanzapina (KAYGISIZ et al, 2022) e clozapina (DE OLIVEIRA; NAGAISHI; BARBOSA SILVA, 2017;LI et al, 2019). Estudos do nosso grupo de pesquisa com modelos preditivos de esquizofrenia em roedores, o MK-801, anfetamina e ketamina prejudicaram o desempenho de roedores no teste de PPI (ANDRADE et al, 2021;CORTEZ et al, 2022;ISSY et al, 2018aISSY et al, , 2020PEDRAZZI et al, 2021b). Esse prejuízo foi prevenido por drogas com potencial propriedade antipsicótica, como o CBD (GOMES et al, 2015a(GOMES et al, , 2015bPEDRAZZI et al, 2021) (GAVIRIA et al, 2015;SUSHMA et al, 2015).…”

Section: Modelos Experimentais De Esquizofreniaunclassified

Avaliação da associação de canabidiol e nitroprussiato de sódio no prejuízo sensório-motor induzido pelo tratamento agudo com MK-801

Amaral

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Ao meu melhor amigo Drauzio, não consigo expressar minha gratidão.Ao Pira, por me incentivar a ir atrás dos meus sonhos, mesmo que tenha que abrir mão de muitas coisas.Ao Leoncio, pelas reflexões no biotério, pelos desabafos, por tudo que me ensinou. Temos que aceitar que tudo tem prazo de validade.Ao Belchior, por sempre me ajudar a tomar decisões e me ensinar a argumentar, mesmo inconscientemente.À Dona Neuza, por me ensinar tanto sobre a vida, a humanidade e suas individualidades. À Célia, por toda ajuda com experimentos e por me ensinar que sempre há uma solução para o problema.Ao Charlie, por me acolher em momentos difíceis dessa jornada.À Glauce e ao Maurício, por todo apoio e inspiração.Ao João Francisco, o Jhony Francis, meu amigo e pai científico, por toda a amizade, acolhimento e ensinamentos.Ao Matias, minha terceira mãe, obrigada pela amizade e por cuidar tanto de mim.A todos do laboratório, minha família científica, por todo companheirismo, apoio e aprendizado.Aos funcionários da Faculdade de Odontologia pelo apoio.Aos animais, que tanto amo. Obrigada por todo o conhecimento proporcionado à ciência e à humanidade. Não tenho palavras e nem o direito de agradecer, mas obrigada.A todos os pacientes de esquizofrenia, que me inspiraram por todo o caminho.À minha querida Unifal, pois minha formação não se iniciou e nem terminará aqui.

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Effects of Doxycycline in Swiss Mice Predictive Models of Schizophrenia

Cited by 6 publications

References 64 publications

Bullous pemphigoid in a patient with a neuropsychological disorder and a possible novel drug trigger: A case report and review of the literature

Bullous pemphigoid in a patient with a neuropsychological disorder and a possible novel drug trigger: A case report and review of the literature

Differential dopamine-mediated effects in the 5-lipoxygenase deficient mice

Avaliação da associação de canabidiol e nitroprussiato de sódio no prejuízo sensório-motor induzido pelo tratamento agudo com MK-801

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