Effects of Doxapram on Postoperative Pulmonary Complications Following Thoracotomy

Abstract

An i.v. solution of 5% dextrose with doxapram 2 mg ml-1 or 5% dextrose alone was administered to 53 patients following lateral thoracotomy. Estimations of arterial PO2, PCO2 and pH were made before operation, during infusion and 7 days after after operation. Respiratory function tests were carried out before and 7 days after operation. There were no significant differences in arterial PO2, PCO2 and pH or in respiratory function tests between those who received doxapram and those who did not. In this study doxapram did not affect the frequency of postoperative pulmonary complications.

Therapeutic applications and biological activities of bacterial bioactive extracts

“…Thus, the fermentation of milk with specific strains of Lactococcus lactis has antithrombotic and hypocholesterolemic activities before and after exposure to a simulated gastrointestinal digestion (SGD) model. Two strains of lactic acid bacteria (LAB) Lc-572 and Lc-571 were shown to release bioactive peptides that inhibit thrombine activity before and after gastrointestinal digestion (Rendon-Rosales et al 2019 ).…”