Effects of Dopexamine and Positive End-Expiratory Pressure on Intestinal Blood Flow and Oxygenation*

Lehtipalo, Stefan; Biber, Björn; Fröjse, Rolf; Arnerlöv, Conny; Johansson, Gillis; Winsö, Ola

doi:10.1378/chest.124.2.688

Cited by 16 publications

(10 citation statements)

References 39 publications

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“…As shown in Fig. 3, jejunal tissue oxygen tension decreased in the OA group, but only to a minor degree, and to absolute levels above ischaemic threshold values of 45 mmHg (Lehtipalo et al. , 2003).…”

Section: Discussionmentioning

confidence: 64%

“…Instrumentation of the animals was performed as previously described regarding intravascular catheters, portal blood flow (Q PORT ), partial tissue O 2 pressure (PtiO 2 ) and jejunal mucosal perfusion (JMP) measurements (Lehtipalo et al. , 2003).…”

Section: Methodsmentioning

confidence: 99%

“…All pressure transducers (System DPT‐6000, PvB; Triplus, Kungsbacka, Sweden) were calibrated to atmospheric pressure at the level of the right atrium by a saline column. Continuous data were acquired with Acknowledge® III (Biopac Systems Inc., Goleta, California, USA) as previously described (Lehtipalo et al. , 2003).…”

Section: Methodsmentioning

confidence: 99%

“…, 1986). Further, we have shown that, in a porcine model, treatment with modest levels of PEEP causes ischaemia when intestinal perfusion pressure is reduced (Lehtipalo et al. , 2003).…”

Section: Introductionmentioning

confidence: 99%

“…The intestine, suggested to be a key organ in the development of multiple organ failure (Mainous et al, 1995;Gullo & Berlot, 1996;Nieuwenhuijzen & Goris, 1999), is well known to be negatively affected by ventilator treatment both in healthy and injured lungs (Winso et al, 1986;Claesson et al, 2003;Guery et al, 2003;Imai et al, 2003;Lehtipalo et al, 2003;Plotz et al, 2004). Research from our own group has shown that treatment with positive end-expiratory pressure (PEEP) reduces portal blood flow during general surgery in man (Winso et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

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Intestinal circulation, oxygenation and metabolism is not affected by oleic acid lung injury

Claesson

Lehtipalo

Bergstrand

et al. 2005

Clin Physio Funct Imaging

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SummaryThis study was performed to establish a platform for further studies on effects of ventilatory treatment modalities on the intestines during mechanical ventilation of acute lung injury (ALI). We tested the hypotheses that oleic acid (OA) infusion causes changes in intestinal circulation, oxygenation and metabolism, and that OA is distributed to tissues outside the lung. This was performed as an experimental, prospective and controlled study in an university animal research laboratory. Thirteen juvenile anaesthetized pigs were used in the main study, where seven were given an intravenous infusion of 0AE1 ml kg )1 OA and six served as control (surgery only). In a separate study, four animals were given an intravenous infusion of 0AE1 ml kg3 H-labelled OA. We measured systemic and mesenteric (portal venous blood flow, jejunal mucosal perfusion) haemodynamic parameters, mesenteric oxygenation (jejunal tissue oxygen tension) and systemic cytokines (tumour necrosis factor-a and interleukin-6). We calculated mesenteric lactate flux and mesenteric oxygen delivery, uptake and extraction ratio. In the animals given 3 H-OA, we measured 3 H-OA in different tissues (lungs, heart, liver, kidney, stomach, jejunum, colon and arterial blood). We found that OA given intravenously is distributed in small amounts to the intestines. This intestinal exposure to OA does not cause intestinal injury when evaluating mesenteric blood flow, metabolism or oxygenation. OA infusion induced a moderate increase in mean pulmonary arterial pressure and a decrease in PaO 2 /Fraction inspired O 2 (P/F) ratio, giving evidence of severe lung injury. Consequently, the OA lung injury model is suitable for studies on intestinal effects of ventilatory treatment modalities during mechanical ventilation of ALI.

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Section: Discussionmentioning

confidence: 64%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…, 1986). Further, we have shown that, in a porcine model, treatment with modest levels of PEEP causes ischaemia when intestinal perfusion pressure is reduced (Lehtipalo et al. , 2003).…”

Section: Introductionmentioning

confidence: 99%