Effects of dopamine reuptake inhibitors on food- and cocaine-maintained responding: II. Comparisons with other drugs and repeated administrations.

Abstract

A previous study (J.R. Glowa, F.H.E. showed that acute doses of GBR 12909 selectively decreased cocaine-maintained responding without affecting foodmaintained responding. This report extended these observations to some related drugs and to the effects of repeated administration. When responding was maintained under a multiple fixed ratio (FR) 30 food, FR 30 cocaine schedule, acute doses of GBR 12935, CFT, and d-amphetamine decreased cocaine-maintained responding more than food-maintained responding. However, in contrast to GBR 12909, none of these drugs completely decreased cocaine-maintained responding without affecting food-maintained responding. Repeated administration of GBR 12909 sustained, and of GBR 12935 improved, these selective decreases in cocaine-maintained responding. The selective effect of these dopamine reuptake inhibitors on cocaine-maintained responding is consistent with their known pharmacological selectivity for the dopamine reuptake site and can be well-maintained with repeated administration.Glowa, found that the high-affinity dopamine (DA) reuptake inhibitor, GBR 12909, could decrease responding maintained by cocaine at doses that did not have effects on comparable rates of food-maintained responding. Similar results have been reported for other drugs. For example, Mello, Mendelson, Bree, & Lucas (1989) reported that the opioid buprenorphine suppressed cocaine self-administration in rhesus monkeys at doses that had little effect on food-maintained responding. These types of effects are of interest because few studies have reported comparable differences in the effects of other drugs on food-and drugmaintained responding. To the extent that it would be desirable for a treatment drug to selectively decrease cocaineseeking behavior, this type of effect may be useful in identifying therapeutic agents comparable to those used for heroin (e.g., methadone) or nicotine (e.g., nicotine patches) abuse. In

Agonist efficacy, drug dependence, and medications development: preclinical evaluation of opioid, dopaminergic, and GABA A -ergic ligands

“…Such procedures are used to evaluate candidate medications for the treatment of dependence on cocaine or other drugs. Results indicate that GBR 12909 decreased rates of responding maintained by cocaine without affecting rates of responding maintained by food, suggesting antagonism of cocaine's reinforcing effects at doses that might not be hampered by side-effects (e.g., Glowa et al 1995). Of interest, other indirect dopamine agonists (e.g.…”

Effects of GBR 12909, WIN 35,428 and indatraline on cocaine self-administration and cocaine seeking in rats

“…Animal studies have shown that pretreatment with the dopamine uptake inhibitor, GBR 12909 (Glowa et al 1995a(Glowa et al , 1995bTella 1995), and other potent dopamine uptake inhibitors (Mansbach et al 1993;Dworkin et al 1998) decreased cocaine selfadministration. Effects of the non-selective monoamine uptake inhibitor, indatraline, have also been examined.…”

Effects of dopamine D 1-like and D 2-like agonists on cocaine self-administration in rhesus monkeys: rapid assessment of cocaine dose-effect functions

“…Selective dopamine reuptake inhibitors have been extensively evaluated in drug self-administration procedures in non-human primates (Bergman et al 1989;Kleven and Woolverton 1993;Mansbach and Balster 1993;Glowa et al 1995;Nader et al 1997;Negus et al 1999), and rapid assessment procedures have been utilized for this objective (Skjoldager et al 1993). Dopaminergic agents are particularly interesting because, although cocaine non-selectively blocks the reuptake of dopamine, norepinephrine, and serotonin (Blackburn et al 1967;Coyle and Snyder 1969;Harris and Baldessarini 1973), the abuse-related effects of cocaine have been most compellingly related to its action as an indirect dopamine agonist (Johanson and Fischman 1989;Koob et al 1997;Caine 1998aCaine , 1998b.…”