Effects of dopamine indirect agonists and selective D1-like and D2-like agonists and antagonists on cocaine self-administration and food maintained responding in rats

Barrett, Andrew C.; Miller, John; Dohrmann, Jennifer M.; Caine, S. Barak

doi:10.1016/j.neuropharm.2004.07.007

Cited by 118 publications

(141 citation statements)

References 63 publications

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“…Although this dose of d-amphetamine administered during self-administration sessions was behaviorally active (e.g., increased ratings of Like Drug and Good Effects, increased heart rate and blood pressure), it approximates the threshold dose to produce reliable behavioral effects (Chait, 1993), suggesting that even higher doses might be necessary to modify d-amphetamine self-administration. There is an extensive pre-clinical literature that has demonstrated that higher pretreatment doses are more effective at decreasing stimulant self-administration than low doses (e.g., Barrett et al, 2004;Harrod et al, 2001;Newman and Beardsley, 2006). Consistent with this notion, the dose of d-amphetamine administered in the present study (i.e., 15 mg) was not effective at modifying drug taking behavior when administered to stimulant-dependent patients Shearer et al, 2001;.…”

Section: Discussionsupporting

confidence: 73%

“…A number of nonhuman laboratory studies have demonstrated that acute stimulant pretreatment can attenuate the reinforcing effects of stimulant drugs (e.g., Barrett et al, 2004). Because either an enhancement or reduction in drug taking was a possible outcome, the doses of d-amphetamine that were selected were expected to engender moderate drug taking.…”

Section: Discussionmentioning

confidence: 99%

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Acute d-amphetamine pretreatment does not alter stimulant self-administration in humans

Stoops¹,

Vansickel²,

Lile³

et al. 2007

Pharmacology Biochemistry and Behavior

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Recent clinical research indicates that d-amphetamine is effective in treating cocaine and methamphetamine dependence. There is concern, however, with the use of d-amphetamine as a pharmacotherapy because acute administration of d-amphetamine decreases inhibition in cocaineusing individuals and may increase drug-taking behavior. The purpose of the present experiment was to determine whether acute d-amphetamine pretreatment would alter the reinforcing, subject-rated, and cardiovascular effects of d-amphetamine. To this end, 7 human volunteers first sampled doses of oral d-amphetamine (0, 8, and 16 mg). These doses engender moderate drug taking and were selected to avoid a ceiling or floor effect. Volunteers were then allowed to self-administer these sampled doses using a modified-progressive ratio procedure in two sessions in which they received pretreatments with either 0 or 15 mg oral d-amphetamine 2 hours prior to completing the modified progressive-ratio procedure. d-Amphetamine produced prototypical stimulant-like effects (e.g., increased ratings of stimulated, elevated blood pressure) and maintained responding on the modified progressive-ratio schedule. Pretreatment with 15 mg oral d-amphetamine also produced prototypical stimulant-like effects, but failed to alter break points for d-amphetamine on the modified progressiveratio procedure relative to placebo pretreatment. These results indicate that acute d-amphetamine pretreatment does not increase stimulant self-administration.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Acute d-amphetamine pretreatment does not alter stimulant self-administration in humans

Stoops¹,

Vansickel²,

Lile³

et al. 2007

Pharmacology Biochemistry and Behavior

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“…Upon stabilization of responding, defined as three consecutive sessions with less than a 20% variation and no increasing or decreasing trend in responding, rats were transferred to a multi-component, 5-dose procedure. Under this procedure, increasing doses of cocaine (0, 0.032, 0.1, 0.32, and 1.0 mg/kg/inj) or methylphenidate (0, 0.01, 0.032, 0.1, and 0.32 mg/kg/inj) were available during five sequential 25 min components (eg, Barrett et al, 2004;Hiranita et al, 2009). Components were initiated by the non-contingent delivery of the unit dose of the drug available for responding, and separated by a 2-min inter-component interval (ICI) during which time the house light was illuminated and responding had no scheduled consequence.…”

Section: Self-administration Studiesmentioning

confidence: 99%

Long-Lasting Effects of a PEGylated Mutant Cocaine Esterase (CocE) on the Reinforcing and Discriminative Stimulus Effects of Cocaine in Rats

Collins

Narasimhan

Cunningham

et al. 2011

Neuropsychopharmacol

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Recent mutagenesis studies have identified a mutant G4C/S10C/T172R/G173Q cocaine esterase (CCRQ CocE) with an in vitro duration of action of 440 days. Although the in vivo duration of CCRQ CocE's action was o24 h, modification of this enzyme with polyethylene glycol (PEG) polymers resulted in a CocE (PEG-CCRQ CocE) capable of preventing cocaine-induced lethality for up to 72 h. The current studies were aimed at providing a detailed characterization of the effectiveness, selectivity, and duration of PEG-CCRQ CocE's actions in cocaine self-administration and discrimination assays in rats. Pretreatment with PEG-CCRQ CocE produced dose-dependent rightward shifts in the dose-response curves for cocaine self-administration and discrimination, with the highest dose of PEG-CCRQ CocE capable of producing an initial shift of cocaine's reinforcing and interoceptive effects of 430-fold to the right, with significant inhibition of these effects observed for up to 72 h. Although PEG-CCRQ CocE also produced slight reductions in the rates of methylphenidate-and foodreinforced responding, these effects were short-lived, lasting o24 h. Finally, when taken together with the finding that PEG-CCRQ CocE failed to alter the cocaine-like interoceptive effects of either methylphenidate or d-amphetamine, these results suggest that PEG-CCRQ CocE possesses a high degree of pharmacologic specificity for cocaine and a prolonged in vivo duration of action. In conclusion, these studies provide strong evidence to support the further development of long-lasting, highly efficient CocEs, such as PEG-CCRQ CocE, as a potential therapeutic option for the treatment of cocaine abuse in humans.

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“…This schedule was increased to an FR3 (5 days), followed by an FR5 (5 days), an FR10 (3 days), and finally a progressive ratio (1 day). Increments in the progressive ratio (PR) schedule within session used the formula 5 × EXP (0.2 × infusion number)-5 [28,29]. Similar to those studies, we replaced the first six values (1, 2, 4, 6, 9, and 12) with 3, 6, and 10, and then continued with the progression provided by the equation.…”

Section: Self-administrationmentioning

confidence: 99%

Immune responses to methamphetamine by active immunization with peptide-based, molecular adjuvant-containing vaccines

Duryee

Bevins

Reichel

et al. 2009

Vaccine

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a b s t r a c tVaccines to methamphetamine (meth) were designed by covalently attaching a meth hapten (METH) to peptide constructs that contained a conformationally biased, response-selective molecular adjuvant, YSFKPMPLaR (EP54). Rats immunized with EP54-containing meth vaccines generated serum antibody titers to authentic meth, an immune outcome that altered meth self-administration. Immunization increased meth self-administration suggesting pharmacokinetic antagonism. The ability of immune sera to bind a METH-modified target protein dramatically decreased during and shortly after the meth selfadministration assay, suggesting effective sequestration of free meth. However, the binding ability of immune sera to the METH-modified target protein was recovered 34 days after meth-free clearance time.

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Effects of dopamine indirect agonists and selective D1-like and D2-like agonists and antagonists on cocaine self-administration and food maintained responding in rats

Cited by 118 publications

References 63 publications

Acute d-amphetamine pretreatment does not alter stimulant self-administration in humans

Acute d-amphetamine pretreatment does not alter stimulant self-administration in humans

Long-Lasting Effects of a PEGylated Mutant Cocaine Esterase (CocE) on the Reinforcing and Discriminative Stimulus Effects of Cocaine in Rats

Immune responses to methamphetamine by active immunization with peptide-based, molecular adjuvant-containing vaccines

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