Effects of domperidone therapy on symptoms and upper gastrointestinal motility in infants with gastroesophageal reflux

Grill, Bruce B.; Hillemeier, A. Craig; Semeraro, Lucille A.; McCallum, Richard W.; Gryboski, Joyce D.

doi:10.1016/s0022-3476(85)80315-2

Cited by 65 publications

(21 citation statements)

References 17 publications

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“…The studies supporting efficacy of domperidone (Motilium, Nauzelin) in improving regurgitation and GOR in infants are limited (Table 3) [5,20,25,42,45,53,63,127]. Most studies have been performed in older children, or investigate the effects of domperidone co-administered with other anti-reflux agents [20,63,127].…”

Section: Domperidonementioning

confidence: 99%

“…Most studies have been performed in older children, or investigate the effects of domperidone co-administered with other anti-reflux agents [20,63,127]. Although pH-metric results [5,20,45,53] appear somewhat better than those with oral metoclopramide [49,76], domperidone controls GOR more consistently when used in combination with antacids or Gaviscon. Domperidone is better tolerated than metoclopramide [22] since dystonic reactions (tremors) and anxiety are infrequent.…”

Section: Domperidonementioning

confidence: 99%

See 1 more Smart Citation

A critical appraisal of current management practices for infant regurgitation - recommendations of a working party

Vandenplas

Belli²,

Benhamou

et al. 1997

European Journal of Pediatrics

126

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A critical appraisal of current management practices for infant regurgitation: recommendations of a working party Vandenplas, Y.; Belli, D.; Benhamou, P.; Cadramel, S.; Cezard, J.P.; Cucchiara, S.; Dupont, C.; Faure, C.; Gottrand, F.; Hassall, E.; Heymans, H.S.A.; Kneepkens, C.M.F.; Sandhu, B. Published in:European Journal of Pediatrics DOI:10.1007/s004310050613Link to publication Citation for published version (APA):Vandenplas, Y., Belli, D., Benhamou, P., Cadramel, S., Cezard, J. P., Cucchiara, S., ... Sandhu, B. (1997). A critical appraisal of current management practices for infant regurgitation: recommendations of a working party. European Journal of Pediatrics, 156, 343-357. DOI: 10.1007/s004310050613 General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Abstract Regurgitation is a common manifestation in infants below the age of 1 year and a frequent reason of counselling of general practitioners and paediatricians. Current management starts with postural and dietary measures, followed by antacids and prokinetics. Recent issues such as an increased risk of sudden infant death in the prone sleeping position and persistent occult gastrooesophageal reflux in a subset of infants receiving milk thickeners or thickened ''anti-regurgitation formula'' challenge the established approach. Therefore, the clinical practices for management of infant regurgitation have been critically evaluated with respect to their efficacy, safety and practical implications.

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Section: Domperidonementioning

confidence: 99%

Section: Domperidonementioning

confidence: 99%

A critical appraisal of current management practices for infant regurgitation - recommendations of a working party

Vandenplas

Belli²,

Benhamou

et al. 1997

European Journal of Pediatrics

126

View full text Add to dashboard Cite

show abstract

“…The prokinetic actions of domperidone are, however, similar to those of metoclopramide. Domperidone is considered more potent but with fewer side effects [41,42]. The usual dosage to achieve a prokinetic effect is 0.3 to 1 mg/kg/day.…”

Section: Therapeutic Methodsmentioning

confidence: 99%

Gastroesophageal Reflux in Infants and Children

El-Mouzan

1991

Ann Saudi Med

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“…There are several small studies demonstrating mixed results in the treatment of gastroesophageal reflux. 49,50 Erythromycin is a motilin receptor agonist that increases motor activity in the stomach and small intestine. Erythromycin has been used in infants with intestinal dysmotility and feeding intolerance.…”

Section: Prokinetic Therapymentioning

confidence: 99%

Clinical Management of Infants and Children with Gastroesophageal Reflux Disease

Whitworth¹,

Christensen

2004

The Journal of Pediatric Pharmacology and Therapeutics

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Gastroesophageal reflux refers to the passage of gastric contents including food, acid, and digestive enzymes up into the esophagus. Reflux is most commonly recognized in infants when it is associated with regurgitation, known as “spitting up,” and it is usually a self-limited, benign process that has little or no effect on normal weight gain or development. Adults and adolescents may also have reflux, which is usually either asymptomatic or recognized as dyspepsia or “heartburn.” Gastroesophageal reflux disease (GERD) is defined as symptoms or complications that result from reflux. Most evidence suggests the mechanism of reflux is due to transient relaxations of the lower esophageal sphincter at inappropriate times. The diagnosis of suspected GERD in infants and children depends on the age and the presenting symptoms. A thorough history, physical examination, and growth charts are sufficient for the evaluation and diagnosis of GERD in most infants with recurrent vomiting or children with regurgitation and heartburn. Additional evaluation may include an upper gastrointestinal series, esophageal pH monitoring, or endoscopy. The goals of GERD management are eliminating symptoms, healing esophagitis, preventing complications, promoting normal weight gain and growth, and maintaining remission. Therapeutic options include lifestyle changes, pharmacologic therapy, and anti-reflux surgery. Currently available pharmacologic agents for the treatment of GERD include antacids, mucosal protectants, prokinetic agents, and acid suppressants.

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Effects of domperidone therapy on symptoms and upper gastrointestinal motility in infants with gastroesophageal reflux

Cited by 65 publications

References 17 publications

A critical appraisal of current management practices for infant regurgitation - recommendations of a working party

A critical appraisal of current management practices for infant regurgitation - recommendations of a working party

Gastroesophageal Reflux in Infants and Children

Clinical Management of Infants and Children with Gastroesophageal Reflux Disease

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