Effects of docosahexaenoic acid–rich n−3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study

Vedin, Inger; Cederholm, Tommy; Freund‐Levi, Yvonne; Basun, Hans; Garlind, Anita; Irving, Gerd Faxén; Jönhagen, Maria Eriksdotter; Vessby, Bengt; Wahlund, Lars‐Olof; Palmblad, Jan

doi:10.1093/ajcn/87.6.1616

Cited by 150 publications

(103 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As reported previously ( 28 ), at study entry DHA and EPA concentration in plasma were not signifi cantly different between the 3 FA and the placebo group. In the 3 FA group, give rise to the highly anti-infl ammatory metabolites resolvins and protectins, which interacts with prostaglandin synthesis ( 11 ).…”

Section: Plasma Fatty Acidssupporting

confidence: 81%

“…Samples were incubated overnight (22 h) in 37°C humidifi ed 5% CO 2 atmosphere. Subsequently, cells were centrifuged, and supernatants were collected and stored in Ϫ 80°C before cytokine determinations ( 28 ).…”

Section: Laboratory Methodsmentioning

confidence: 99%

“…Data for all 174 patients in the OmegAD study have been given previously ( 7 ). Likewise, data for the present 21 patients have been given ( 28 ).…”

Section: Plasma Fatty Acid Analysesmentioning

confidence: 99%

See 2 more Smart Citations

Reduced prostaglandin F2α release from blood mononuclear leukocytes after oral supplementation of ω3 fatty acids: the OmegAD study

Vedin

Cederholm

Freund‐Levi

et al. 2010

Journal of Lipid Research

Self Cite

View full text Add to dashboard Cite

Section: Plasma Fatty Acidssupporting

confidence: 81%

Section: Laboratory Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Reduced prostaglandin F2α release from blood mononuclear leukocytes after oral supplementation of ω3 fatty acids: the OmegAD study

Vedin

Cederholm

Freund‐Levi

et al. 2010

Journal of Lipid Research

Self Cite

View full text Add to dashboard Cite

“…Indeed, DHA/EPA dietary supplementation in healthy subjects blunted the endocrine stress response and the increase in body temperature, with or without impact on cytokine production after bacterial endotoxin administration (Ferguson et al, 2014;Michaeli et al, 2007). AD patients supplemented with a DHA-rich diet display reduced release of proinflammatory cytokines (IL-1β, IL-6, GM-CSF) from stimulated peripheral blood mononuclear cells (Vedin et al, 2008). In addition, students with DHA/EPA supplementation show a decreased anxiety and proinflammatory cytokines production only in ex vivo stimulated immune cells but not in the plasma (Kiecolt-Glaser et al, 2011).…”

Section: N-pufas Neuroinflammation and Cognitive Disordersmentioning

confidence: 99%

N-3 PUFAs and neuroinflammatory processes in cognitive disorders

Leyrolle

Layé

Nadjar

2016

OCL

View full text Add to dashboard Cite

-With the ageing population and increased cases of neurodegenerative diseases, there is a crucial need for the development of new nutritional approaches to prevent and delay the onset of cognitive decline. Neuroinflammatory processes contribute to neuronal damage that underpins neurodegenerative disorders. Growing evidence sheds light on the use of dietary n-3 long chain polyunsaturated fatty acids to improve cognitive performances and reduce the neuroinflammatory responses occurring with age and neurodegenerative pathologies. This review will summarise the most recent information related to the impact and mechanisms underlying the neuroinflammatory processes in cognitive disorders. We will also discuss the mechanisms underlying n-3 polyunsaturated fatty acids effect on neuroinflammation and memory decline.Keywords: Neuroinflammation / microglia / n-3 polyunsaturated fatty acids / cognitive disorders / Alzheimer disease Résumé -Acides gras polyinsaturés de la famille des oméga 3, processus neuroinflammatoires et troubles cognitifs. Le développement d'approches nutritionnelles pertinentes pour prévenir et retarder l'apparition du déclin cognitif est un enjeu important, compte tenu du vieillissement de la population et de l'augmentation de l'incidence des maladies neurodégénératives. Les processus neuro-inflammatoires contribuent aux mécanismes neuropathologiques impliqués dans les troubles neurodégénératifs et de la cognition. Des données récentes indiquent l'importance des acides gras polyinsaturés n-3 alimentaires dans le maintien des performances mnésiques et la régulation de la neuroinflammation liée à l'âge ou à la maladie d'Alzheimer. Dans cette revue, seront présentées des données récentes sur les liens existants entre le statut nutritionnel en acides gras polyinsaturés n-3, les processus neuro-inflammatoires et les troubles cognitifs associés, ainsi que les mécanismes qui pourraient être impliqués dans les effets protecteurs de ces acides gras.

show abstract

“…These effects have been ascribed to the improvement of cardiovascular risk profiles, resulting in disease prevention21; however, the data on IHD and hypertension are less robust. Clinical trials in post–myocardial infarction patients have suggested that DHA, specifically, may exert a therapeutic effect, particularly on hypertension and the risk of reinfarction,22 although this has not been shown unequivocally or linked with atherosclerotic plaque stabilization/regression 23, 24. DHA supplementation decreased blood pressure in spontaneously hypertensive rats25, 26 and in a dog model of hypertension,27 but no data are available for mouse models with atherosclerosis.…”

mentioning

confidence: 99%

Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism

Alfaidi

Chamberlain

Rothman

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundHypertension is a complex condition and a common cardiovascular risk factor. Dietary docosahexaenoic acid (DHA) modulates atherosclerosis and hypertension, possibly via an inflammatory mechanism. IL‐1 (interleukin 1) has an established role in atherosclerosis and inflammation, although whether IL‐1 inhibition modulates blood pressure is unclear.Methods and ResultsMale apoE−/− (apolipoprotein E–null) mice were fed either a high fat diet or a high fat diet plus DHA (300 mg/kg per day) for 12 weeks. Blood pressure and cardiac function were assessed, and effects of DHA on wall shear stress and atherosclerosis were determined. DHA supplementation improved left ventricular function, reduced wall shear stress and oscillatory shear at ostia in the descending aorta, and significantly lowered blood pressure compared with controls (119.5±7 versus 159.7±3 mm Hg, P<0.001, n=4 per group). Analysis of atheroma following DHA feeding in mice demonstrated a 4‐fold reduction in lesion burden in distal aortas and in brachiocephalic arteries (P<0.001, n=12 per group). In addition, DHA treatment selectively decreased plaque endothelial IL‐1β (P<0.01).ConclusionsOur findings revealed that raised blood pressure can be reduced by inhibiting IL‐1 indirectly by administration of DHA in the diet through a mechanism that involves a reduction in wall shear stress and local expression of the proinflammatory cytokine IL‐1β.

show abstract

Effects of docosahexaenoic acid–rich n−3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study

Cited by 150 publications

References 35 publications

Reduced prostaglandin F2α release from blood mononuclear leukocytes after oral supplementation of ω3 fatty acids: the OmegAD study

Reduced prostaglandin F2α release from blood mononuclear leukocytes after oral supplementation of ω3 fatty acids: the OmegAD study

N-3 PUFAs and neuroinflammatory processes in cognitive disorders

Dietary Docosahexaenoic Acid Reduces Oscillatory Wall Shear Stress, Atherosclerosis, and Hypertension, Most Likely Mediated via an IL‐1–Mediated Mechanism

Contact Info

Product

Resources

About