Effects of DMSO on a rabbit ear hypertrophic scar model: A controlled randomized experimental study

Sarı, Elif; Bakar, Bülent; Dinçel, Güngör Çağdaş; Yildiran, Fatma Azize Budak

doi:10.1016/j.bjps.2017.01.006

Cited by 16 publications

(13 citation statements)

References 27 publications

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“…Topical TAC in this study caused significant reduction of TGF-β1 as compared to induced scar non-treated group after 21 days of treatment (p ≤ 0.05) that is in accordance with Sari et al [44] which found significant differences of pro-inflammatory cytokines TGF-β1 and collagen III in rabbit ear model after treatment with topical TAC.…”

Section: Discussionsupporting

confidence: 91%

Effect of Crude Extract and Phytosterol Fraction of Fumaria Officinalis in Induced Hypertrophic Scar of Rabbits

Noori

Abu-Raghif

2019

Asian J Pharm Clin Res

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Objective: The present study aimed to evaluate the role of crude extract and phytosterol fraction of Fumaria officinalis in experimentally induced hypertrophic scar in rabbits. Methods: Surgical wounds were performed on day 1 with an 8‑mm biopsy punch four wounds were created on the ventral surface of the rabbit ear (in vivo) down to cartilage. Triamcinolone acetonide (TAC), crude and phytosterol extracts of F. officinalis L. are administered topically to established scars on day 31. The outcome measures included study of histopathology of skin sections, transforming growth factor beta‑1 (TGF‑β1), level, and collagen three alpha1 in skin tissue. Results: In comparison with the induced hypertrophic scar, all treatment produced a significant reduction in scores of TGFβ1, collagen III, inflammation, and measurement of SEI (p ≤ 0.01). The most significant reduction in inflammation and thickness observed in TAC and extract of crude F. officinalis L. Only crude F. officinalis L. decrease fibroblast counts in comparison to induced hypertrophic scar group and other group (p ≤ 0.05). No statistically significant differences were found between the treatment groups in terms of TGF β1and collagen III. Conclusion: Topical crude extract of F. officinalis L. was more effective in the treatment of induced hypertrophic scar as compared with phytosterol of F. officinalis L. and comparable to the effectiveness of topical TAC.

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Section: Discussionsupporting

confidence: 91%

Effect of Crude Extract and Phytosterol Fraction of Fumaria Officinalis in Induced Hypertrophic Scar of Rabbits

Noori

Abu-Raghif

2019

Asian J Pharm Clin Res

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“…DMSO has a broad spectrum of biological activity and is increasingly used in medicines due to its antiinflammatory, trophic and conductive properties [54]. The mechanisms of DMSO action have mostly been studied in neurobiology [55] where the drug was shown to exhibit anticholinesterase action [56], block the reuptake of choline and glutamate [57,58] and modulate neuronal activity (including choliner-gic function) [55,58,59].…”

Section: Dmso Can Regulate the Efficiency Of Hbh Preconditioning As Amentioning

confidence: 99%

The Acoustic Sensorimotor Gating Predicts the Efficiency of Hypoxic Preconditioning. Participation of the Cholinergic System in This Phenomenon

Захарова¹,

Сторожева²,

Proshin³

et al. 2018

JBiSE

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Moderate one-off hypobaric hypoxia (HBH) provokes preconditioning and prolongs the resistance (T, the time before apnoea) to severe hypobaric hypoxia (SHBH). Hypoxic preconditioning has therapeutic potential; however, the efficiency of hypoxic preconditioning varies greatly and the methods for its preliminary evaluation are absent in both animals and humans. This rodent study evaluates the dependence of SHBH resistance, initiated by HBH, on the rate of sensorimotor gating estimated in the model of the acoustic startle prepulse inhibition (PPI). A stable negative correlation was found between PPI and T. Low doses of the α7 nicotinic receptor agonist, PNU-282987 (PNU), and more pronouncedly dimethyl sulfoxide (DMSO) (a PNU solvent), inverted the correlation between PPI and T from negative to positive. The DMSO and PNU effects were reversed at PPIs of 0.36 -0.40 (36% -40%). DMSO increased T values by 52.2% ± 9.7% in the region of lower HBH efficiency (PPI ≥ 0.40) and reduced it by 35.2% ± 9.3% in the region of higher HBH efficiency (PPI < 0.40). PNU reduced both DMSO effects. The involvement of the central cholinergic mechanisms was substantiated in both DMSO and PNU influences on HBH. In conclusion, 1) PPI can be used to predict the efficiency of hypoxic preconditioning and to study its mechanisms, 2) two opposite cholinergic PPI-related mechanisms participate in the preconditioning effects of HBH, 3) the sensitivity of rats to DMSO and PNU diverges when the PPI is 0.36 -0.40,

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“…Besides, fibroblasts are activated and differentiated into myofibroblasts, both of which are responsible for wound contraction and closure during HS formation. The proliferative fibroblasts produce massive collagens, resulting in significant increase of collagen type I and type III in HS [14,15]. Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone for collagen folding and secretion.…”

Section: Discussionmentioning

confidence: 99%

Inhibition effects of a negative electret 5-FU patch on the growth of a hypertrophic scar

Wang

Huang

et al. 2018

Plasma Sci. Technol.

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In this study, the hypertrophic scar (HS) model in rats was established. 5-fluorouracil (5-FU) patch, −1000 V and −2000 V polypropylene (PP) electret 5-FU patches were prepared and applied onto the wound. The in vitro permeation experiment was performed using the Franz diffusion cell system to determine the permeation cumulative amount and retention amount of 5-FU through/in scar skin. The inhibition effect of negative electret on growth of HS was studied by hematoxylin-eosin (HE) staining, Masson staining and the immunohistologicall methods. The permeation study indicated that a negative electret could enhance the permeation and retention of 5-FU through and in scar skin respectively. HE staining and Masson staining indicated a better effect for −1000 V and −2000 V electret 5-FU patches on HS inhibition after 28 d post-wounding compared with 5-FU patch. The immunohistological study showed much more reduced expressions of collegan type I, collegan type III, TGF-β1 and HSP47 in scar tissue after application of negative electret 5-FU patches than those of 5-FU patch. A negative electret 5-FU patch may be advantageous for HS treatment.

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Effects of DMSO on a rabbit ear hypertrophic scar model: A controlled randomized experimental study

Cited by 16 publications

References 27 publications

Effect of Crude Extract and Phytosterol Fraction of Fumaria Officinalis in Induced Hypertrophic Scar of Rabbits

Effect of Crude Extract and Phytosterol Fraction of Fumaria Officinalis in Induced Hypertrophic Scar of Rabbits

The Acoustic Sensorimotor Gating Predicts the Efficiency of Hypoxic Preconditioning. Participation of the Cholinergic System in This Phenomenon

Inhibition effects of a negative electret 5-FU patch on the growth of a hypertrophic scar

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