Abstract:Vascular cognitive impairment (VCI) have been one of the main type of cognitive impairment. Chronic cerebral hypoperfusion (CCH) is the main cause of VCI. Blood-brain barrier damage plays an essential part in the pathogenesis of CCH induced cognitive impairment. At present, the treatment to VCI mainly focused on prevention, there is no drug clinically approved for the treatment of VCI. This study investigated the effects of DL-3-n-butylphthalide (NBP) on cognitive function and blood-brain barrier in chronic ce… Show more
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