“…Those currents include a Na ϩ -selective channel from rabbit proximal tubules (Gögelein and Greger, 1986;Jacobsen et al, 1988) that is sensitive to Ca 2ϩ (Blokkebak-Poulsen et al, 1991) and a Na ϩ channel in LLC-PK1 cells (Raychowdhury et al, 2004), a cell line with proximal tubule characteristics derived from pig kidney. Furthermore, several studies describe an amilorideinsensitive and thus ENaC-independent pathway for Na ϩ entry in epithelial cells of various organs, such as lung (Shlyonsky et al, 2005), colon (Inagaki et al, 2004), and esophagus (Awayda et al, 2004).…”