Effects of diterpenes from latex of Euphorbia lactea and Euphorbia laurifolia on human immunodeficiency virus type 1 reactivation

Avila, Liliana; Perez, M. P. Burkhardt; Sánchez‐Duffhues, Gonzalo; Hernández-Galán, Rosario; Muñóz, Eduardo; Cabezas, Fabio; Quiñones, Winston; Torres, Fernando; Echeverri, Fernándo

doi:10.1016/j.phytochem.2009.10.005

Cited by 43 publications

(48 citation statements)

References 24 publications

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“…This activity in plant latexes is due to presence of various active components such as Alpha-D-mannosidase and N-acetyl-beta-D-glucosaminidase [5], dieterpenes [4], certain proteases [36] and chitinases [37]. Similar activity against phyto-pathogens is reported in latexes of Calotropis procera (CpLP), Plumeria rubra (PrLP), Ca-rica candamarcensis (P1G10) and Euphorbia tirucalli (EtLP) due to presence of antimicrobial proteins [6].…”

Section: Discussionmentioning

confidence: 74%

“…It is a mixture of many pharmaceutically active substances which showed very high anti-bacterial [2], antiviral [3], antifungal [4] anti-protozoan activity. Latex from several plant species such as A. ochroleuca [2] Calotropis procera, Plumeria rubra, Carica candamarcensis, Euphorbia tirucalli (EtLP) [5], Erythrina variegata [6], Jatropha curcas, Hancornia speciosa Gomes (Apocynaceae) [7], C. procera [8], and Euphorbia lathyris [9] have shown very high antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Activity of Fruit Latexes from Ten Laticiferous Plants

Upadhyay¹

2015

AJPS

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In the present investigation antibacterial activity of latexes from ten Indian plant species Spondias dulcis (Amra), Diospyros melanoxylon (Tendu), Terminalia bellirica (Wahera), Ficus glomerata (Gular), Phyllanthus emblica (Awla), Thevetia neriifolia (Kaner), Carica papaya (Papita), Calotropis procera (Ak), Ficus benghalensis (Bargad), Artocarpus heterophyllus (Kathal) collected from Gorakhpur, North India were determined in various in vitro systems. MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) values were determined in growth inhibitory bioassays by using different increasing concentrations of various latex extracts. Latex samples were diluted by using serial micro dilution method up to 10 −10 method with Luria broth culture medium. These values were obtained significantly 2 -3 times lower than that of broad spectrum antibiotic drugs. Besides this, inhibition zone diameters were measured in agar disc diffusion assay. A known volume i.e. 0.1 -20 μg/μl of each latex were coated on separate sterile filter paper discs (Whatman No. 1) measuring 6 mm in size. Latex fractions registered significantly higher growth inhibition than that of broad spectrum antimicrobial drugs. Present study indicates the potential use of shows that both latex and its components and latex as are valuable source of medicinal products/active principles that can be used for treatment of life threatening infectious diseases. Because of higher inhibitory and cidal potential obtained in latexes than the synthetic drugs these that could lead to become efficient phytomedicines mainly to have and develop as complete drug formulations against to control infectious microbes.

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Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Fruit Latexes from Ten Laticiferous Plants

Upadhyay¹

2015

AJPS

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“…Several studies have shown that some of the ingol diterpenes can reactivate latent HIV in cell culture models in vitro. [57][58][59] The ingol diterpene 8-methoxyingol 7,12-diacetate 3-phenylacetate was isolated from Euphorbia officinarum. It caused G 0 /G 1 cell cycle arrest in J-Lat cells without significant cytotoxicity.…”

Section: Ingenol Compoundsmentioning

confidence: 99%

“…Since it is not a tumor promoter, it may be a candidate for further studies. 58 The third diterpene, compound 3, was isolated from Euphorbia lactea, and it activated 80% of the latent HIV in the cells at an EC 50 of 0.5 lg/ml 59 (Fig. 8).…”

Section: Ingenol Compoundsmentioning

confidence: 99%

Targeting NF-κB Signaling with Protein Kinase C Agonists As an Emerging Strategy for Combating HIV Latency

Jiang

Dandekar

2015

AIDS Research and Human Retroviruses

118

120

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Highly active antiretroviral therapy (HAART) is very effective in suppressing HIV-1 replication and restoring immune functions in HIV-infected individuals. However, it fails to eradicate the latent viral reservoirs and fully resolve chronic inflammation in HIV infection. The ''shock-and-kill'' strategy was recently proposed to induce latent HIV expression in the presence of HAART. Recent studies have shown that the protein kinase C (PKC) agonists are highly potent in inducing latent HIV expression from the viral reservoirs in vitro and ex vivo and in protecting primary CD4 + T cells from HIV infection through down-modulation of their HIV coreceptor expression. The PKC agonists are excellent candidates for advancing to clinical HIV eradication strategies. This article will present a critical review of the structure and function of known PKC agonists, their mechanisms for the reactivation of latent HIV expression, and the potential of these compounds for advancing clinical HIV eradication strategies.

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“…Diterpenoids isolated from Euphorbia species represent a unique group of structurally diverse compounds that possess remarkable biological activities [28][29][30][31][32], such as potent antiviral activity against human immunodeficiency virus (HIV) for tigliane- [33], ingenane- [29,34,35] and macrocyclic-type esters [36][37][38], or powerful P-glycoprotein modulation activity for macrocyclic diterpene esters [39,40].…”

Section: Introductionmentioning

confidence: 99%

LC-MS2-Based dereplication of Euphorbia extracts with anti-Chikungunya virus activity

et al. 2015

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Recently, phorbol esters from Euphorbiaceae have been shown to elicit potent and selective antiviral activity on the replication of Chikungunya virus (CHIKV) in cell culture. With the objective to found new compounds with anti-CHIKV activities, 45 extracts from various plant parts of 11 Mediterranean Euphorbia and one Mercurialis species were evaluated for selective inhibition of CHIKV replication. All EtOAc extracts, especially those prepared from latex, exhibited significant and selective antiviral activity in a Chikungunya virus-cell-based assay. An LC-MS(2) dereplication method was then developed to investigate whether known diterpenoids with anti-CHIKV activity, such as the potent anti-CHIKV 12-O-tetradecanoylphorbol-13-acetate (TPA), phorbol-12,13-didecanoate, and prostratin as well as 24 other commercially available diterpenoids of tigliane-, ingenane-, and daphnane-type for which the anti-CHIKV activity have been established in advance (Nothias-Scaglia et al. 2015), were present in the Euphorbia extracts. Only ingenol-3-mebutate, 13-O-isobutyryl-12-deoxyphorbol-20-acetate, and ingenol-3,20-dibenzoate, all exhibiting weak anti-CHIKV activities, were detected in the EtOAc extracts of Euphorbia peplus, Euphorbia segetalis ssp. pinea, and Euphorbia pithyusa ssp. pithyusa. Given the potent anti-CHIKV activities of these Euphorbia extracts, the present study suggested that their antiviral activities are probably due to untargeted diterpenoids.

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Effects of diterpenes from latex of Euphorbia lactea and Euphorbia laurifolia on human immunodeficiency virus type 1 reactivation

Cited by 43 publications

References 24 publications

Antimicrobial Activity of Fruit Latexes from Ten Laticiferous Plants

Antimicrobial Activity of Fruit Latexes from Ten Laticiferous Plants

Targeting NF-κB Signaling with Protein Kinase C Agonists As an Emerging Strategy for Combating HIV Latency

LC-MS2-Based dereplication of Euphorbia extracts with anti-Chikungunya virus activity

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