Effects of disruption of hippocampal function on learning of a go/no-go discrimination in the rat

Livesey, P. J.; Meyer, Peter N.; Smith, J. P.

doi:10.1016/0006-8993(80)90877-x

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…However, this would not account for the effect observed with similar cortical stimulation in a go-no-go task when learning of that task was, in fact, significantly facilitated. In discussing this latter finding, Livesey et al (1980) suggested it might be due to an alerting or a potentiating effect, particularly as Walker and his co-workers had found that lesions in a similar cortical region led to depressed performance in a go T no-go alternation task (Means, Walker, & Isaacson, 1970;Walker, Means, & Isaac-son, 1970). The significance of these cortical effects is thus still not resolved.…”

Section: Discussionmentioning

confidence: 99%

“…The variable results from small lesions noted by Douglas (1967) may well have been due to differentiation of function within the hippocampus. Using localized electrical stimulation to disrupt hippocampal function, Livesey and co-workers demonstrated differential effects in the learning of both simultaneous and go-no-go discrimination tasks (Livesey, 1975;Livesey, Meyer, & Smith, 1980). The effects of stimulation varied both with the location stimulated (CA1 or dentate gyms of the dorsal hippocampus in the rat) and with the temporal location in the stimulus-response sequence at which the stimulation was applied.…”

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confidence: 99%

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Disruption of passive avoidance learning in the rat by electrical stimulation of the hippocampus.

Livesey¹,

Bell²,

Manyam³

1984

Behavioral Neuroscience

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The effect of electrical stimulation to discrete regions of the dorsal hippocampus on passive avoidance was examined in five experiments. Rats stepped from a brightly lit, white compartment to a dark compartment. Following footshock in the dark compartment, step-through latencies were recorded 1 min, 24 hr, and 48 hr after footshock. When given 20 step-through trials prior to footshock, dentate-stimulated animals exhibited lack of passive avoidance with particularly short latencies at 1 min, and CA1 rats showed reduced latencies compared with latencies of cortical and nonoperated controls. In Experiment 2, rats given stimulation in the same regions performed the avoidance task without prior step-through experience. All groups showed less passive avoidance than the control group in Experiment 1, and there were no significant differences between groups. With a single step-through trial before the footshock trial, longer avoidance latencies were recorded, but again groups did not differ significantly. Dentate-implanted animals, given 20 prior exposure trials but with stimulation at different stages of the task sequence, demonstrated a passive avoidance deficit at 1 min after footshock. The results are discussed in terms of the generation of expectancy that the black compartment was a safe place and the effects of brain stimulation on the expectancy, with particular reference to Vinogradova's (1975) theory of hippocampal function.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Disruption of passive avoidance learning in the rat by electrical stimulation of the hippocampus.

Livesey¹,

Bell²,

Manyam³

1984

Behavioral Neuroscience

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“…A second point at which the lesion might have affected performance was during the reversal phase of the experiment. Many experiments have shown that rats with hippocampal lesions tend to perseverate, to respond on the basis of original training conditions when those conditions have been changed (e.g., Douglas, 1972; Livesey & Meyer, 1975; Livesey, Meyer, & Smith, 1980). However, the lesion animals in this experiment clearly did not do that.…”

Section: Methodsmentioning

confidence: 99%

Effects of intrahippocampal administration of colchicine on incentive contrast and on radial maze performance.

Flaherty¹,

Rowan-Szal²,

Emerich³

et al. 1989

Behavioral Neuroscience

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The behavior of rats given intradentate injections of the neurotoxin colchicine was examined in three experimental settings. In Experiment 1, colchicine-treated, artificial cerebrospinal fluid (CSF)-treated, and untreated animals did not differ in the intake of 32% and 4% sucrose solutions, nor did they differ in degree of successive negative contrast when the 32% solution was changed to 4% sucrose. In Experiment 2, the colchicine-treated and CSF-treated animals did not differ in degree of suppression in the intake of a 0.15% saccharin solution when it preceded 32% sucrose in once-daily pairings (anticipatory contrast), nor did they differ in reversal performance when saccharin-sucrose and saccharin-saccharin pairings were reversed. In Experiment 3, the colchicine-treated animals were substantially impaired in radial-arm maze performance compared with CSF-treated controls. These results suggest that a completely functioning hippocampus is not necessary for the memory of reward quality, the comparison of rewards, the suppression of behavior when reward is decreased, the formation of associations between two levels of reward, and the reversal of this association, as long as these processes are reflected in consummatory behavior. The data are interpreted in terms of differences between instrumental behavior and sensory memory and/or consummatory behavior--an interpretation that is not incompatible with a deficiency in working memory in the animals with lesions.

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Learning deficits on avoidance task and hippocampal lesions in area CA3 following intraperitoneal administration of 3‐acetylpyridine

Ozaki

Murakami

Shimada

1983

J of Neuroscience Research

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Young adult mice of the ddN-F26 strain were given a single intraperitoneal injection of 3-acetylpyridine (3-AP) at a dosage of 200 mg/kg body weight. Two weeks after this treatment, learning on avoidance task was tested with a training apparatus called a jump-box. Each mouse was subjected to 30 trials of training per week for 3 or 4 weeks. Contrasted to untreated mice, the mean performance of the 3-AP-treated mice on avoidance training was significantly reduced in every weekly training session. However, since the learning scores of individual 3-AP-treated mice were highly varied, these mice were divided into several groups according to the characteristics of their learning patterns in order to analyze the relationships between learning ability and brain damage. It was found that there was a close association between the rate of learning deficits and the degree of destruction of the pyramidal cells in area CA3 of the hippocampus in mice treated with 3-AP. The present data suggest that the area CA3 neurons play an important role on the acquisition of avoidance task and memory formation.

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Effects of disruption of hippocampal function on learning of a go/no-go discrimination in the rat

Cited by 6 publications

References 14 publications

Disruption of passive avoidance learning in the rat by electrical stimulation of the hippocampus.

Disruption of passive avoidance learning in the rat by electrical stimulation of the hippocampus.

Effects of intrahippocampal administration of colchicine on incentive contrast and on radial maze performance.

Learning deficits on avoidance task and hippocampal lesions in area CA3 following intraperitoneal administration of 3‐acetylpyridine

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