Effects of Disease Stage and Zidovudine Therapy on the Detection of Human Immunodeficiency Virus Type 1 in Semen

Anderson, Deborah J.; O’Brien, Thomas R.; Politch, Joseph A.; Martinez, Adriana; Seage, George R.; Padian, Nancy; Horsburgh, C. Robert; Mayer, Kenneth H.

doi:10.1001/jama.1992.03480200077028

Cited by 144 publications

(32 citation statements)

References 25 publications

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“…Our study also confirmed a positive association between seminal leucocytosis and HIV-1 in semen, as reported in previous studies [2,25]. From the present study, it could be concluded that there exists a clear association between leucocytospermia and HIV infection.…”

Section: Discussionsupporting

confidence: 93%

“…Semen is an important vehicle for sexual transmission of HIV-1 [9], yet relatively little is known about the frequency and location of HIV within semen or its constituents [16,25]. Epidemiologic studies indicate that HIV-1 transmission via semen to sexual partners occurs with varying degrees of efficiency [2]. Conflicting reports exist with regard to effects of HIV on sperm characteristics [1,9,10].…”

Section: E Umapathy Et Almentioning

confidence: 99%

See 1 more Smart Citation

Sperm Characteristics and Accessory Sex Gland Functions in Hiv-Infected Men

Umapathy¹,

Simbini²,

Chipata³

et al. 2001

Archives of Andrology

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Section: Discussionsupporting

confidence: 93%

Section: E Umapathy Et Almentioning

confidence: 99%

Sperm Characteristics and Accessory Sex Gland Functions in Hiv-Infected Men

Umapathy¹,

Simbini²,

Chipata³

et al. 2001

Archives of Andrology

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“…HIV-1 levels in semen have been associated with LCS (33,34). More recently, Krause and colleagues (12) compared the prevalence of CMV, EBV and HSV antibodies in serum of men with and without LCS.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Bezold

Politch

Kiviat

et al. 2007

Fertility and Sterility

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218

167

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Objective-To determine the prevalence of pathogens that cause sexually transmitted infections (STIs) in semen from asymptomatic male infertility patients with and without leukocytospermia (LCS), and associations between STIs, inflammatory markers and other semen variables.Design-Retrospective, controlled study. Results-STI DNA was detected in 45/241 (18.7%) of the samples (CMV 8.7%, HPV 4.5%, HHV-6 3.7%, HSV 3.7%, CT 2.5%, EBV 0.4%, and HBV 0%), with no difference in prevalence between LCS and non-LCS groups. STI DNA in semen was associated with a decrease in sperm concentration, motile sperm concentration, total sperm count and neutral α-glucosidase concentration, whereas LCS was associated with a decrease in total sperm count, % normal forms and fructose concentration. Setting-CenterReprint requests: Deborah J. Anderson, Ph.D., Department of Obstetrics and Gynecology, Boston University School of Medicine, 670 Albany Street, Suite 516, Boston, MA 02118, (FAX: 617-414-8481; e-mail: E-mail: deborah.anderson@bmc.org). Capsule: Sexually transmissible pathogens were detected in 19% of semen samples from infertility patients seeking routine semen analyses; their presence was not associated with leukocytospermia, but was associated with reduced semen quality.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusion(s)-STI pathogen DNA was detected in semen from a high percentage of asymptomatic male infertility patients and was associated with poor semen quality. Efforts to diagnose and treat subclinical genital tract infections should be intensified. NIH Public Access

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“…1,5 ART may decrease the likelihood of further HIV transmission by reducing circulating levels of HIV RNA. [7][8][9][10][11][12][13][14][15][16] Treatment of other sexually transmitted diseases (STD) and coinfections [17][18][19][20][21][22] may also decrease the likelihood of further HIV transmission. In addition, care providers can help promote safer behaviors among their HIV-infected clients.…”

mentioning

confidence: 99%