Effects of disease severity and necrosis on pancreatic dysfunction after acute pancreatitis

Garip, Gokhan; Sarandöl, Emre; Kaya, Ekrem

doi:10.3748/wjg.v19.i44.8065

Cited by 46 publications

(47 citation statements)

References 17 publications

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“…5,22,23 The low incidence of pancreatic dysfunction in our study is probably related to the fact that only one patient developed necrotising AP, since that is a known risk factor for subsequent pancreatic dysfunction. 22,23 Pancreatogenic diabetes is in concordance with the definition by Ewald and Bretzal, 24 related to the presence of pancreatic exocrine insufficiency measured by FE; the present study only revealed a FE below the lower level of normal in two cases, neither of which were treated with antidiabetics, and which showed no evidence of prediabetes or diabetes in the obtained tests. The question is whether only patients with necrotising pancreatitis and subsequent chronic pancreatitis develop a significant loss of b-cell function and thus T3cDM (type 3c diabetes mellitus).…”

Section: Discussionmentioning

confidence: 74%

Pancreatic function following post‐endoscopic retrograde cholangiopancreatography pancreatitis: A controlled cohort study with long‐term follow‐up

et al. 2018

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Section: Discussionmentioning

confidence: 74%

Pancreatic function following post‐endoscopic retrograde cholangiopancreatography pancreatitis: A controlled cohort study with long‐term follow‐up

et al. 2018

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“… 1 Additionally, severe acute pancreatitis has been known to cause an endocrine insufficiency over months, and whether this insulin-deficiency in combination with the glucose-dependent mechanisms of the human heart predispose TCM merits further investigation. 14 …”

Section: Discussionmentioning

confidence: 99%

Acute Pancreatitis-Induced Takotsubo Cardiomyopathy in an African American Male

Bruenjes

Vallabhajosyula

Vacek

et al. 2016

ACG Case Reports Journal

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Takotsubo cardiomyopathy (TCM) is triggered by multiple physical and psychological stressors and frequently mimics acute coronary syndrome. Acute pancreatitis as a trigger for TCM has rarely been reported. We report a 55-year-old African American man with hypertension and alcohol abuse history, who presented with epigastric and sub-sternal pain and electrocardiogram demonstrating ischemic changes. Laboratory parameters revealed elevated troponin-I, amylase, lipase, and metabolic acidosis. He was diagnosed with acute pancreatitis and ACS. Coronary angiogram was unrevealing for coronary atherosclerosis and he was managed conservatively for acute pancreatitis and heart failure from TCM.

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“…The severity of AP was defined, based on the 2012 revision of the Atlanta classification and definitions by international consensus [ 15 ]. AP was subdivided into two types: interstitial edematous pancreatitis (AEP) and necrotising pancreatitis (ANP), in accordance with the appearance of CECT and the existence of pancreatic necrosis [ 17 ]. This clinical classification defined three degrees of severity: mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP).…”

Section: Methodsmentioning

confidence: 99%

Influence of Fatty Liver on the Severity and Clinical Outcome in Acute Pancreatitis

Qiao

et al. 2015

PLoS ONE

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Acute pancreatitis (AP) is a common disease in the department of gastroenterology with variable severity, from being mild and self-limited to severe and fatal. The early diagnosis and accurate prediction of AP severity are of great importance. Our primary observation showed that fatty liver (FL) was frequently detected in patients with AP. In this retrospective study, we aimed to evaluate the relation between FL and the severity and outcomes of AP. The medical records of 2671 patients with AP were reviewed retrospectively, and characteristics of AP patients were recorded. FL was assessed by abdominal CT scan, and AP patients were categorized by the occurrence of FL for the analysis. The variation of mortality, clinical severity and the appearance of CT were analyzed between the non-FL group and FL groups. Compared with patients without FL, an obviously higher rate of death and higher frequency of severe AP (SAP) and necrotizing AP (ANP) were observed in patients with FL, as well as the incidence of local complications and systemic complications. Taking obesity into consideration, a higher rate of death and more severe AP were found in patients with FL, no matter whether they were obese or not. Alcoholic fatty liver (AFL) and non-alcoholic fatty liver (NAFL) were also separated for comparison in this study; the incidence of ANP and the clinical severity had no significant difference between the AFL and NAFL groups. In conclusion, FL could influence the severity and clinical outcome and may play a prognostic role in AP. This study is of clinical significance, because few reports have been previously issued on FL and AP.

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Effects of disease severity and necrosis on pancreatic dysfunction after acute pancreatitis

Abstract: Patients with SAP, NAP, pancreatic head necrosis and necrosectomy should be followed for pancreatic functions.

Cited by 46 publications

References 17 publications

Pancreatic function following post‐endoscopic retrograde cholangiopancreatography pancreatitis: A controlled cohort study with long‐term follow‐up

Pancreatic function following post‐endoscopic retrograde cholangiopancreatography pancreatitis: A controlled cohort study with long‐term follow‐up

Acute Pancreatitis-Induced Takotsubo Cardiomyopathy in an African American Male

Influence of Fatty Liver on the Severity and Clinical Outcome in Acute Pancreatitis

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