Effects of discontinuing coffee intake on iron deficient Guatemalan toddlers' cognitive development and sleep

Engle, Patrice L.; VasDias, T.; Howard, Ian S.; Romero-Abal, M.E.; Serrano, J Quan de; Bulux, Jesús; Solomons, Noel W.; Dewey, Kathryn G.

doi:10.1016/s0378-3782(98)00080-2

Cited by 22 publications

(15 citation statements)

References 50 publications

(61 reference statements)

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“…In addition, there were fewer than 20 infants per group to evaluate treatment effects. Another study of Guatemalan toddlers did not find any relationship between anemia and sleep (daytime, nighttime, and total sleep hours, nighttime waking, and napping frequency) when measured before an intervention to reduce coffee intake 9. The intervention also did not impact sleep, but it had no effect on iron status,10 possibly explaining lack of sleep effects.…”

mentioning

confidence: 97%

The Effects of Iron and/or Zinc Supplementation on Maternal Reports of Sleep in Infants from Nepal and Zanzibar

Kordas¹,

Siegel²,

Olney³

et al. 2009

Journal of Developmental &Amp; Behavioral Pediatrics

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Background There is some evidence that sleep patterns may be affected by iron deficiency anemia but the role of iron in sleep has not been tested in a randomized iron supplementation trial. Objective We investigated the effect of iron supplementation on maternal reports of sleep in infants in 2 randomized, placebo-controlled trials from Pemba Island, Zanzibar, and Nepal. Design In both studies, which had parallel designs and were carried out in years 2002 to 2003, infants received iron–folic acid with or without zinc daily for 12 months, and assessments of development were made every 3 months for the duration of the study. Eight hundred seventy-seven Pemban (12.5 ± 4.0 months old) and 567 Nepali (10.8 ± 4.0 months) infants participated. Maternal reports of sleep patterns (napping frequency and duration, nighttime sleep duration, frequency of night waking) were collected. Results Mean Hb concentration was 9.2 ± 1.1 for Pemban and 10.1 ± 1.2 g/dL for Nepali infants. Approximately, one-third of the children were stunted. Supplemental iron was consistently associated with longer night and total sleep duration. The effects of zinc supplementation also included longer sleep duration. Conclusions Micronutrient supplementation in infants at high risk for iron deficiency and iron deficiency anemia was related to increased night sleep duration and less night waking.

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confidence: 97%

The Effects of Iron and/or Zinc Supplementation on Maternal Reports of Sleep in Infants from Nepal and Zanzibar

Kordas¹,

Siegel²,

Olney³

et al. 2009

Journal of Developmental &Amp; Behavioral Pediatrics

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“…1982; because we did not have adequate record data of use of anesthetic or analgesics during delivery, we assessed whether the baby was born by C-section as a proxy), and maternal caffeine intake during pregnancy (Engle et al, 1999). An additional three variables chosen had been identified in previous research as potentially relevant to individual differences in neonatal iron status.…”

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confidence: 99%

Relation of neonatal iron status to individual variability in neonatal temperament

Wachs

Pollitt

Cueto

et al. 2005

Developmental Psychobiology

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The relation between indices of neonatal iron status and individual differences in neonatal temperament were investigated in a sample of 148 low-income Peruvian women and their newborn infants. Using cord blood, at birth we obtained measures of neonatal ferritin, serum iron, and hemoglobin. While neonates were still in the hospital, their behavior during a structured anthropometry examination was videotaped and subsequently coded on four temperament dimensions: activity level, negative emotionality, alertness, and soothability. The same dimensions were coded using a videotape obtained during a subsequent visit to the neonates' homes. Results indicated that lower levels of neonatal hemoglobin and serum iron were related to higher levels of negative emotionality and to lower levels of alertness and soothability. A similar pattern was found for ferritin, but only for females. For the most part, relations between neonatal iron measures and neonatal temperament were linear, operating across the full range of iron values. Our pattern of iron-temperament results could not be attributed to variation in family demographics, low birth weight, gestational age, maternal dietary intake, or markers of neonatal illness and maternal diabetes. Our findings are consistent with prior research with older infants relating iron deficiency to temperament. These results support the importance of increased research on the early functional-behavioral consequences of individual differences in iron status as well as on the mechanisms that underlie such consequences.

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“…Only 1 study explored the effect of discontinuation of coffee intake among iron-deficient toddlers employing a randomized design. 32 None of these studies revealed any differences in sleep difficulty or number of times waking at night. In clinical settings, studies in which caffeine was used to treat apnea of prematurity revealed that caffeine did not modify either the duration of active sleep 41 or the total sleep time or the sleep stage durations of preterm infants.…”

Section: Discussionmentioning

confidence: 90%

“…With regard to the prevalence of caffeine consumption and of heavy caffeine consumption during pregnancy, it is similar to that observed almost a decade ago in this same city, 21 reinforcing the notion that coffee and mate consumption are deeply rooted cultural behaviors, as already highlighted by others. 32,33 Maternal caffeine consumption, even in large amounts during gestation and lactation, had no consequences on sleep of the infant at 3 months of age. The reason for no association is not clear.…”

Section: Discussionmentioning

confidence: 99%

Maternal Caffeine Consumption and Infant Nighttime Waking: Prospective Cohort Study

2012

PEDIATRICS

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WHAT'S KNOWN ON THIS SUBJECT: Fetus and infants until 3 months of age are unable to metabolize caffeine, which crosses the placenta and in adults has a somnolytic effect. Little is known about the effect of caffeine consumption by pregnant or nursing mothers over infant sleeping. WHAT THIS STUDY ADDS:In this setting where caffeine is largely consumed in pregnancy and by nursing mothers, heavy consumption ($300 mg/day) did not increase the number of nighttime awakenings by their 3-month-old infants.abstract OBJECTIVE: Coffee and other caffeinated beverages are commonly consumed in pregnancy. In adults, caffeine may interfere with sleep onset and have a dose-response effect similar to those seen during insomnia. In infancy, nighttime waking is a common event. With this study, we aimed to investigate if maternal caffeine consumption during pregnancy and lactation leads to frequent nocturnal awakening among infants at 3 months of age.METHODS: All children born in the city of Pelotas, Brazil, during 2004 were enrolled on a cohort study. Mothers were interviewed at delivery and after 3 months to obtain information on caffeine drinking consumption, sociodemographic, reproductive, and behavioral characteristics. Infant sleeping pattern in the previous 15 days was obtained from a subsample. Night waking was defined as an episode of infant arousal that woke the parents during nighttime. Multivariable analysis was performed by using Poisson regression. RESULTS:The subsample included 885 of the 4231 infants born in 2004. All but 1 mother consumed caffeine in pregnancy. Nearly 20% were heavy consumers ($300 mg/day) during pregnancy and 14.3% at 3 months postpartum. Prevalence of frequent nighttime awakeners (.3 episodes per night) was 13.8% (95% confidence interval: 11.5%-16.0%). The highest prevalence ratio was observed among breastfed infants from mothers consuming $300 mg/day during the whole pregnancy and in the postpartum period (1.65; 95% confidence interval: 0.86-3.17) but at a nonsignificant level.CONCLUSIONS: Caffeine consumption during pregnancy and by nursing mothers seems not to have consequences on sleep of infants at the age of 3 months. Pediatrics 2012;129:860-868

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Effects of discontinuing coffee intake on iron deficient Guatemalan toddlers' cognitive development and sleep

Cited by 22 publications

References 50 publications

The Effects of Iron and/or Zinc Supplementation on Maternal Reports of Sleep in Infants from Nepal and Zanzibar

The Effects of Iron and/or Zinc Supplementation on Maternal Reports of Sleep in Infants from Nepal and Zanzibar

Relation of neonatal iron status to individual variability in neonatal temperament

Maternal Caffeine Consumption and Infant Nighttime Waking: Prospective Cohort Study

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