Effects of diphenhydramine HCl and methylprednisolone in the prevention of abdominal adhesions

Avşar, Fatih Mehmet; Şahi̇n, Mustafa; Aksoy, Faruk; Avşar, Ayşe Filiz; Aköz, Mehmet; Hengirmen, Süleyman; Bilici, Sami

doi:10.1016/s0002-9610(01)00617-1

Cited by 39 publications

(54 citation statements)

References 9 publications

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“…There are many experimental models for the development of inflammatory and postoperative adhesions including the local peritoneal model, the damaged uterine horn, introduction of foreign objects in the abdominal and pelvic cavity, the direct mechanical intestinal damage, the ileal transection, the thermal damage, the large bowel anastomosis, the bacterial contamination, and the scraping models [16,17,19,20,22] . In this study, the parietal peritoneal model was chosen due to the similarities of the physiopathology after abdominal surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it was chosen to wait 10 days before performing relaparotomy because other studies had shown high adhesion scores at the period of this time [4,5,27] . There have many adhesion scoring systems described by researchers in experimental models [4][5][6]16,17,22] . Macroscopical and histopathological evaluations were made according to semiquantitative scoring systems that had been described by Mazuji et al [24] and Hooker et al [25] .…”

Section: Discussionmentioning

confidence: 99%

“…Macroscopical and histopathological evaluations were made according to semiquantitative scoring systems that had been described by Mazuji et al [24] and Hooker et al [25] . To date mentioned evaluations which have been used by many reseachers [4,22,23] is simple and suitable scoring systems for use in experimental studies.…”

Section: Discussionmentioning

confidence: 99%

“…NSAIDs decrease vascular permeability, platelet aggregation, plasmine inhibitor and coagulation, and enhance macrophage function [1,2,7] . Some researchers [7,10,11,22] have demonstrated that NSAIDs have been used to prevent the adhesion formations by blocking the initial stage of inflammatory response. An optimal barrier should be non-toxic, biodegradable, easily appliable, without compromising wound healing, remain active in the presence of body fluids, and dissolved after 1 to 2 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…A current interest to overcome adhesions have been focused on various combination of drugs [2,4,8,9,[17][18][19][20][21][22][23] . Therefore, it was to investigate the effect of HA/CMC, flunixin meglumine and their combination on the prevention of postoperative intraabdominal adhesions in rabbits.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Hyaluronic Acid/Carboxymethylcellulose and Flunixin Meglumine Combination on the Prevention of Postoperative Intraabdominal Adhesions: An Experimental Study in Rabbits

Köm¹

2013

Kafkas Univ Vet Fak Derg

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Despite the development in the knowledge concerning pathophysiology of abdominal cavity and improvement in surgical techniques, intraabdominal adhesions are one of the most common complications in surgery. The aim of this study was to determine the effects of hyaluronic acid/carboxymethylcellulose (HA/CMC) and flunixin meglumine combination on the prevention of postoperative intraabdominal adhesions in rabbits. All the surgery were made under aseptic condition under general anesthesia. A 2x2 cm area of parietal peritoneum was resected on the abdominal wall after median laparotomy. Twenty-four adult, male rabbits were divided into four groups equally. Groups were evaluated as C (control), S (HA/CMC), F (flunixin meglumine), and SF (HA/CMC and flunixin meglumine combination). No medication was given to the rabbits in group C. In S and SF groups, 3x3 cm of HA/CMC applied directly to peritoneal defect. In F and SF groups, flunixin meglumine was administred 1.1 mg/kg for 5 days intraperitoneally. Relaparotomy was performed 10 days after surgery. As a result of macroscopical and histopathological evaluations, the scores of adhesion in the S, F, and SF groups were significantly lower than those of the control group (P<0.05). Adhesion scores in SF group were lower as compared to S and F groups (P<0.05). It is observed that HA/CMC and flunixin meglumine combination can be used more effective on the prevention of postoperative intraabdominal adhesions in rabbits.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Hyaluronic Acid/Carboxymethylcellulose and Flunixin Meglumine Combination on the Prevention of Postoperative Intraabdominal Adhesions: An Experimental Study in Rabbits

Köm¹

2013

Kafkas Univ Vet Fak Derg

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Prevention of postoperative adhesion formation by individual and combined administration of 4 per cent icodextrin and dimetindene maleate

Tepetes

Asprodini

Christodoulidis

et al. 2009

British Journal of Surgery

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Intraperitoneal adhesions—an ongoing challenge between biomedical engineering and the life sciences

Brochhausen

Schmitt

Rajab

et al. 2011

J Biomedical Materials Res

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Peritoneal adhesions remain a relevant clinical problem despite the currently available prophylactic barrier materials. So far, the physical separation of traumatized serosa areas using barriers represents the most important clinical strategy for adhesion prevention. However, the optimal material has not yet been found. Further optimization or pharmacological functionalization of these barriers could give an innovative input for peritoneal adhesion prevention. Therefore, a more complete understanding of pathogenesis is required. On the basis of the pathophysiology of adhesion formation the main barriers currently in clinical practice as well as new innovations are discussed in the present review. Physiologically, mesothelial cells play a decisive role in providing a frictionless gliding surface on the serosa. Adhesion formation results from a cascade of events and is regulated by a variety of cellular and humoral factors. The main clinically applied strategy for adhesion prevention is based on the use of liquid or solid adhesion barriers to separate physically any denuded tissue. Both animal and human trials have not yet been able to identify the optimal barrier to prevent adhesion formation in a sustainable way. Therefore, further developments are required for effective prevention of postoperative adhesion formation. To reach this goal the combination of structural modification and pharmacological functionalization of barrier materials should be addressed. Achieving this aim requires the interaction between basic research, materials science and clinical expertise.

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Effects of diphenhydramine HCl and methylprednisolone in the prevention of abdominal adhesions

Cited by 39 publications

References 9 publications

Effect of Hyaluronic Acid/Carboxymethylcellulose and Flunixin Meglumine Combination on the Prevention of Postoperative Intraabdominal Adhesions: An Experimental Study in Rabbits

Effect of Hyaluronic Acid/Carboxymethylcellulose and Flunixin Meglumine Combination on the Prevention of Postoperative Intraabdominal Adhesions: An Experimental Study in Rabbits

Prevention of postoperative adhesion formation by individual and combined administration of 4 per cent icodextrin and dimetindene maleate

Intraperitoneal adhesions—an ongoing challenge between biomedical engineering and the life sciences

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