Effects of Different Vasodilators on Human Internal Mammary Artery in Vitro

Mahmoudian, Massoud; Shafiei, Massoumeh; Mirkhani, Hossein; Omrani, Gholamreza

doi:10.1007/978-1-4615-4717-4_51

Cited by 4 publications

(5 citation statements)

References 17 publications

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“…The responses of vascular preparations which are used in CABG to the available vasodilator drugs are considered in many studies [1][2][3][4][5]. In the present research, the effect of a new inotropic/vasodilator agent, i. e. levosimendan, on the contractions of IMA and SV was studied and compared with that of papaverine.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the reversal of this vasospasm is often challenging, and the most effective therapy is not well defined. Several studies have been carried out to investigate the effects of currently available vasodilators on IMA vasospasm [1][2][3][4][5]. On the other hand, SV is generally considered as an inactive conduit for blood passage but some authors claim that it also has the potential to elicit responses to vasoactive substances.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the Effects of Levosimendan and Papaverine on Human Internal Mammary Artery and Saphenous Vein

Mirkhani

Shafa

Khazraei

2009

Cardiovasc Drugs Ther

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of the Effects of Levosimendan and Papaverine on Human Internal Mammary Artery and Saphenous Vein

Mirkhani

Shafa

Khazraei

2009

Cardiovasc Drugs Ther

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“…Mebudipine and dibudipine showed a vasorelaxant effect on human as well as animal artery preparations [11,15]. Mebudipine also showed a more potent vasorelaxant effect on isolated rat aorta compared to nifedipine [7].…”

Section: Discussionmentioning

confidence: 98%

“…The inhibitory effects of mebudipine on PE (E max )-induced increments in perfusion pressure are greater than that of nifedipine. Mebudipine and dibudipine are two potent and selective L-type calcium channel blockers [15]. It has been proposed that mebudipine has a greater affinity to bind to inactivated channels, compared to nifedipine [19].…”

Section: Discussionmentioning

confidence: 99%

Effect of the Two New Calcium Channel Blockers Mebudipine and Dibudipine in Comparison to Nifedipine on Vascular Flow of Isolated Rat Kidney

Sepehr-Ara

Babapoor²,

Oryan³

et al. 2009

Sci. Pharm.

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In previous researches mebudipine and dibudipine two newly synthesized calcium channel blockers (CCBs) showed considerable relaxant effects on vascular and atrial smooth muscle cells. In this study we investigated the effects of these new drugs on vascular flow of isolated rat kidney and compare their potencies to nifedipine. It is concluded that mebudipine and dibudipine (5 μM, 10 μM) caused concentration-dependent inhibition of increases in perfusion pressure induced by phenylephrine. Mebudipine (10 μM) inhibited more greatly increases in perfusion pressure induced by phenylephrine compared to (10 μM) nifedipine.

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“…The compounds also antagonize the contractile responses of K þ depolarized guineapig ileum to cumulative concentrations of calcium with the inhibitory effects in the order mebudipine > nifedipine ¼ dibudipine. The vasorelaxant actions of mebudipine and dibudipine have been reproduced in a human vascular preparation (Mahmoudian et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Metabolism of the dihydropyridine calcium channel blockers mebudipine and dibudipine by isolated rat hepatocytes

Bohlooli

Mahmoudian

Skellern

et al. 2004

Journal of Pharmacy and Pharmacology

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The prototype 1,4-dihydropyridine (1,4-DHP) nifedipine, indicated for the management of hypertension and angina pectoris, has drawbacks of rapid onset of vasodilating action and a short half-life. Several newer analogues have been designed to offset these problems and these include mebudipine and dibudipine. These analogues contain t-butyl substituents that have been selected to alter the fast metabolism without altering pharmacological activity. In this study, the metabolism of mebudipine and dibudipine by isolated rat hepatocytes has been investigated. These compounds were extensively metabolized in 2 h by oxidative pathways, analogous to those known for nifedipine, and by O-glucuronidation after hydroxylation of the t-butyl substituents. The in-vitro half-lives of mebudipine (22 +/- 7.1 min) and dibudipine (40 +/- 9.8 min) were significantly longer than that of nifedipine (5.5 +/- 1.1 min), which was investigated in parallel in this study. These newer 1,4-DHPs address the problem of the short half-life of nifedipine and have potential for further development in view of their comparable potency to nifedipine.

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Effects of Different Vasodilators on Human Internal Mammary Artery in Vitro

Cited by 4 publications

References 17 publications

Comparison of the Effects of Levosimendan and Papaverine on Human Internal Mammary Artery and Saphenous Vein

Comparison of the Effects of Levosimendan and Papaverine on Human Internal Mammary Artery and Saphenous Vein

Effect of the Two New Calcium Channel Blockers Mebudipine and Dibudipine in Comparison to Nifedipine on Vascular Flow of Isolated Rat Kidney

Metabolism of the dihydropyridine calcium channel blockers mebudipine and dibudipine by isolated rat hepatocytes

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