Effects of different variants of the FASN gene on production performance and milk fatty acid composition in Holstein × Simmental dairy cows

Maurić, Maja; Mašek, Tomislav; Ljoljić, Darija Bendelja; Grbavac, Jozo; Starčević, Kristina

doi:10.17221/73/2018-vetmed

Cited by 8 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, other authors have suggested a genomic approach to a complex description of the genetic background; this option helps to increase the chances of identifying loci associated with economically important traits [ 8 , 9 ]. The significant effect of FASN gene polymorphisms was also confirmed by other authors [ 10 ]. Additionally, other gene polymorphisms were studied in relation to the FA profile, for example, GH ( growth hormone ), MSTN ( myostatin ), FADS2 ( fatty acid desaturase 2 ), CPM ( carboxypeptidase ), THRSP ( thyroid hormone-inducible hepatic protein ), ACACA ( acetyl-CoA carboxylase alpha ), AGPAT3 ( 1-acylglycerol-3-phosphate O-acyltransferase 3 ) [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionsupporting

confidence: 83%

“…Only the saturated iso C14:0, C16:0, iso C16:0, C20:0 and C22:0 showed significance, and C14:1n-5 c , C16:1n-7 c , C20:4n-3 were practically identical in models with all genes. Maurić et al [ 10 ] found a slightly higher effect of the breed when comparing the Simmental and Holstein Simmental crossbreeds. In another study, weak effects were found [ 33 ], as in our analysis.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Associations among Farm, Breed, Lactation Stage and Parity, Gene Polymorphisms and the Fatty Acid Profile of Milk from Holstein, Simmental and Their Crosses

Samková

Čítek

Brzáková

et al. 2021

Animals

View full text Add to dashboard Cite

This study aimed to analyze the factors affecting the fatty acid (FA) profile in cow’s milk. The effects of a farm, lactation parity and stage, breed and polymorphisms in the AGPAT6, DGAT1, LEP, FASN and SCD1 genes were evaluated. A total of 196 Holstein cows, 226 Simmental cows and seven crosses were sampled 751 times. The cows were kept at five farms and were in the first up to the sixth lactation, and 49 individual FAs and 11 groups were analyzed. The farm significantly affected the proportion of all FAs except for C16:1n-7c and isoC14:0. Additionally, the lactation stage was significant for most FAs, and the opposite was true for lactation parity. The effect of the breed was negligible. For the gene polymorphisms, the SCD1 TT genotype exceeded the CC in C10:0, C12:0, C14:0, C16:1n-7c and C18:2, and the opposite was true for C10:1, C12:1, C14:1n-5c, isoC17:0, C16:1 and C18:1, i.e., the TT genotype was higher for saturated FAs, and the CT genotype was higher for monounsaturated FAs. The results hint at the intermediary heredity of the SCD1 gene. The FASN gene was strongly associated with four FAs and branched-chain FAs, and genotype AG was better than GG. LEP was significant for five individual FAs and branched-chain FAs. The differences in FA composition among genotypes were rather small, which could lead to overestimation of the effect and needs to be considered in the next research.

show abstract

Section: Introductionsupporting

confidence: 83%

Section: Resultsmentioning

confidence: 99%

Associations among Farm, Breed, Lactation Stage and Parity, Gene Polymorphisms and the Fatty Acid Profile of Milk from Holstein, Simmental and Their Crosses

Samková

Čítek

Brzáková

et al. 2021

Animals

View full text Add to dashboard Cite

show abstract

“…A large number of studies covering crossbred cows compare the performance of crossbred cows to one of the parental breeds [ 34 , 68 , 69 , 70 ], or include only the performance of the F1 generation in comparison to both parental breeds [ 12 , 71 ]. To our knowledge, our study belongs to the very few studies including not only the F1 crossbred generation and both parental breeds, but covers also the crossbred generations following the F1 in a crisscross breeding system like is common for the “Kiwi-Cross” breeding system in New Zealand.…”

Section: Discussionmentioning

confidence: 99%

Energy Balance Indicators during the Transition Period and Early Lactation of Purebred Holstein and Simmental Cows and Their Crosses

Knob

Neto

Schweizer

et al. 2021

Animals

View full text Add to dashboard Cite

Crossbreeding in dairy cattle has been used to improve functional traits, milk composition, and efficiency of Holstein herds. The objective of the study was to compare indicators of the metabolic energy balance, nonesterified fatty acids (NEFA), beta-hydroxybutyrate (BHBA), glucose, body condition score (BCS) back fat thickness (BFT), as well as milk yield and milk composition of Holstein and Simmental cows, and their crosses from the prepartum period until the 100th day of lactation at the Livestock Center of the Ludwig Maximilians University (Munich, Germany). In total, 164 cows formed five genetic groups according to their theoretic proportion of Holstein and Simmental genes as follows: Holstein (100% Holstein; n = 9), R1-Hol (51–99% Holstein; n = 30), first generation (F1) crossbreds (50% Holstein, 50% Simmental; n = 17), R1-Sim (1–49% Holstein; n = 81) and Simmental (100% Simmental; n = 27). The study took place between April 2018 and August 2019. BCS, BFT blood parameters, such as BHBA, glucose, and NEFA were recorded weekly. A mixed model analysis with fixed effects breed, week (relative to calving), the interaction of breed and week, parity, calving year, calving season, milking season, and the repeated measure effect of cow was used. BCS increased with the Simmental proportion. All genetic groups lost BCS and BFT after calving. Simmental cows showed lower NEFA values. BHBA and glucose did not differ among genetic groups, but they differed depending on the week relative to calving. Simmental and R1-Sim cows showed a smaller effect than the other genetic groups regarding changes in body weight, BCS, or back fat thickness after a period of a negative energy balance after calving. There was no significant difference for milk yield among genetic groups, although Simmental cows showed a lower milk yield after the third week after calving. Generally, Simmental and R1-Simmental cows seemed to deal better with a negative energy balance after calving than purebred Holstein and the other crossbred lines. Based on a positive heterosis effect of 10.06% for energy corrected milk (ECM), the F1, however, was the most efficient crossbred line.

show abstract

“…Animals with the CC genotype compare favourably with individuals with other genotypes in terms of milk yield [ 11 ]. Also, LEP , fatty acid synthase ( FASN ) and other gene polymorphisms were studied [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Gene polymorphisms influencing yield, composition and technological properties of milk from Czech Simmental and Holstein cows

Čítek¹,

Brzáková

Hanusová

et al. 2021

Anim Biosci

View full text Add to dashboard Cite

Objective: The aim of the study was to evaluate the influence of polymorphic loci and other factors on milk performance and the technological properties of milk.Methods: The analysis was performed on Simmental and Holstein cows in field conditions (n = 748). Milk yield in kg, fat and protein percentage and yield were evaluated. Technological properties were evaluated by milk fermentation ability, renneting, and an alcohol test. Polymorphisms in the acyl-CoA diacylgycerol transferase 1 (DGAT1), leptin (LEP), fatty acid synthase (FASN), stearoyl CoA desaturase 1 (SCD1), casein beta (CSN2), casein kappa (CSN3), and lactoglobulin beta genes were genotyped, and association analysis was performed.Results: The DGAT1 AA genotype was associated with higher milk, protein and fat yields (p<0.05). The MM genotype in the LEP gene was associated with a lower protein percentage and the W allele with a higher protein percentage (p<0.05). In cows with the FASN GG genotype, the protein percentage was higher, but the A allele was associated with higher milk, protein and fat yields than the G allele. The TT genotype in SCD1 was associated with the lowest milk, protein and fat yields and with the highest milk protein percentage (p<0.01). The T allele had higher values than the C allele (p<0.05) except for fat percentage. The genotype CSN3 AA was associated with a significantly heightened milk yield; BB was associated with a high protein percentage. The effect of the alleles on the technological properties was not significant. The CSN3 BB genotype was associated with the best alcohol test (p<0.01), and the renneting order was inverse. Milk from cows with the CSN2 A1A1 genotype was best in the milk fermentation ability. CSN3 significantly affected the technological properties.Conclusion: The findings revealed the potential of some polymorphic loci for use in dairy cattle breeding and for the management of milk quality. In field research, the pivotal role of farms in milk yield, composition and technological properties was confirmed.

show abstract

Effects of different variants of the FASN gene on production performance and milk fatty acid composition in Holstein × Simmental dairy cows

Cited by 8 publications

References 19 publications

Associations among Farm, Breed, Lactation Stage and Parity, Gene Polymorphisms and the Fatty Acid Profile of Milk from Holstein, Simmental and Their Crosses

Associations among Farm, Breed, Lactation Stage and Parity, Gene Polymorphisms and the Fatty Acid Profile of Milk from Holstein, Simmental and Their Crosses

Energy Balance Indicators during the Transition Period and Early Lactation of Purebred Holstein and Simmental Cows and Their Crosses

Gene polymorphisms influencing yield, composition and technological properties of milk from Czech Simmental and Holstein cows

Contact Info

Product

Resources

About