Effects of different types of exercise on skeletal muscle atrophy, antioxidant capacity and growth factors expression following myocardial infarction

Cai, Mengxin; Wang, Qing'an; Liu, Zhiwei; Jia, Dandan; Feng, Rui; Tian, Zhenjun

doi:10.1016/j.lfs.2018.10.015

Cited by 38 publications

(46 citation statements)

References 68 publications

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“… 29 In rats, the performance of resistance exercise is effective in reducing oxidative stress, increasing antioxidant capacity, decreasing protein degradation, and regulating growth factor expression in skeletal muscle. 30 The molecular mechanism of resistance exercise in regulating symptoms, physical function, and QoL in cancer patients undergoing chemotherapy is still unknown. Since resistant exercise reduces the toxic effects in gastrointestinal cancer patients caused by chemotherapy, the molecular mechanism during this process is needed to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

Effects of Resistance Exercise on Symptoms, Physical Function, and Quality of Life in Gastrointestinal Cancer Patients Undergoing Chemotherapy

Hong

2020

Integr Cancer Ther

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This research aimed to investigate the effects of resistance exercise on symptoms, physical function, and quality of life (QoL) in gastrointestinal cancer patients undergoing chemotherapy. Patients were quasi-randomly divided into the resistance exercise group and the relaxation control group, and machine-based resistance exercise was performed twice a week for 12 weeks under the guidance of experienced therapists. The QoL of patients was analyzed by EORTC-QLQ-C30. Resistance exercise training significantly reduced the incidences of lack of energy (inter-group P = .011), nausea (inter-group P = .007), acid reflux (inter-group P = .042), and back pain (inter-group P = .0009). Twelve weeks of resistance exercise training significantly elevated the muscular strength of leg press (inter-group P = .021) and leg extension (inter-group P = .041), and the muscular endurance of leg press (inter-group P = .005). The participants’ performance in 6-m fast walk (inter-group P = .008), 6-m backwards walk (inter-group P = .016), and chair rise (inter-group P = .031) were dramatically improved. Fatigue (inter-group P = .024) and appetite loss (inter-group P = .012) in the resistance exercise group were significantly lower than the relaxation control group. In conclusion, the beneficial effects of resistance exercise on symptoms, physical function and QoL in gastrointestinal cancer patients undergoing chemotherapy were demonstrated. Resistance exercise training reduced the incidences of nausea and acid reflux, improved physical function, and alleviated fatigue and appetite loss in gastrointestinal cancer patients undergoing chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Effects of Resistance Exercise on Symptoms, Physical Function, and Quality of Life in Gastrointestinal Cancer Patients Undergoing Chemotherapy

Hong

2020

Integr Cancer Ther

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“…Other animal studies showed that exercise can promote a protective reaction against irreversible tissue damage produced by ischemic injury in the myocardium [19,20]. Moreover, exercise training may attenuate post-MI remodeling independent of the preconditioning effect.…”

Section: Discussionmentioning

confidence: 98%

Voluntary exercise and cardiac remodeling in a myocardial infarction model

et al. 2020

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AbstractWe investigated the effects of voluntary exercise after myocardial infarction (MI) on cardiac function, remodeling, and inflammation. Male C57BL/6J mice were divided into the following four groups: sedentary + sham (Sed-Sh), sedentary + MI (Sed-MI), exercise + sham (Ex-Sh), and exercise + MI (Ex-MI). MI induction was performed by ligation of the left coronary artery. Exercise consisting of voluntary wheel running started after the operation and continued for 4 weeks. The Ex-MI mice had significantly increased cardiac function compared with the Sed-MI mice. The Ex-MI mice showed significantly reduced expression levels of tumor necrosis factor-α, interleukin (IL)-1β, IL-6, and IL-10 in the infarcted area of the left ventricle compared with the Sed-MI mice. In the Ex-MI mice, the expression levels of fibrosis-related genes including collagen I and III were decreased compared to the Sed-MI mice, and the expression levels of IL-1β, IL-6, follistatin-like 1, fibroblast growth factor 21, and mitochondrial function-related genes were significantly elevated in skeletal muscle compared with the Sed mice. The plasma levels of IL-6 were also significantly elevated in the Ex-MI group compared with the Sed-MI groups. These findings suggest that voluntary exercise after MI may improve in cardiac remodeling associated with anti-inflammatory effects in the myocardium and myokine production in the skeletal muscles.

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“…Similar results were observed in animal models. For example, AET upregulated IGF-1 levels through activated Akt and ERK1/2 signaling while reducing forkhead box O3 (FoxO3) mRNA levels in the skeletal muscle of myocardial infarction model [ 84 , 86 ]. An animal study by Bacurau et al [ 80 ] demonstrated that 8 weeks of AET prevented muscle loss by activating Akt and mammalian target of rapamycin (mTOR) and subsequently increasing the phosphorylation of p70-S6 kinase 1 (p70S6K).…”

Section: Effects Of Exercise On Hf-related Sarcopeniamentioning

confidence: 99%

“…Compared with the baseline, RT induced a 1.5-fold increase in 50% of maximum work rate along with muscle capillary density, fiber cross-section area, and percentage area of type I fiber [ 78 ]. Cai et al [ 84 ] reported that 4 weeks of RT inhibited muscle atrophy by downregulating the mRNA levels of MuRF-1 and atrogin-1, decreased ROS, and upregulated the IGF-1/Akt/ERK signaling pathway in soleus muscle. These data indicate that the regulation of protein synthesis-related genes in skeletal muscle may be modulated in response to RT in HF.…”

Section: Effects Of Exercise On Hf-related Sarcopeniamentioning

confidence: 99%

Exercise as a Therapeutic Strategy for Sarcopenia in Heart Failure: Insights into Underlying Mechanisms

Cho

Choi

Sajgalik

et al. 2020

Cells

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Sarcopenia, a syndrome commonly seen in elderly populations, is often characterized by a gradual loss of skeletal muscle, leading to the decline of muscle strength and physical performance. Growing evidence suggests that the prevalence of sarcopenia increases in patients with heart failure (HF), which is a dominant pathogenesis in the aging heart. HF causes diverse metabolic complications that may result in sarcopenia. Therefore, sarcopenia may act as a strong predictor of frailty, disability, and mortality associated with HF. Currently, standard treatments for slowing muscle loss in patients with HF are not available. Therefore, here, we review the pathophysiological mechanisms underlying sarcopenia in HF as well as current knowledge regarding the beneficial effects of exercise on sarcopenia in HF and related mechanisms, including hormonal changes, myostatin, oxidative stress, inflammation, apoptosis, autophagy, the ubiquitin-proteasome system, and insulin resistance.

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Effects of different types of exercise on skeletal muscle atrophy, antioxidant capacity and growth factors expression following myocardial infarction

Cited by 38 publications

References 68 publications

Effects of Resistance Exercise on Symptoms, Physical Function, and Quality of Life in Gastrointestinal Cancer Patients Undergoing Chemotherapy

Effects of Resistance Exercise on Symptoms, Physical Function, and Quality of Life in Gastrointestinal Cancer Patients Undergoing Chemotherapy

Voluntary exercise and cardiac remodeling in a myocardial infarction model

Exercise as a Therapeutic Strategy for Sarcopenia in Heart Failure: Insights into Underlying Mechanisms

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