Effects of different selenium sources and levels on antioxidant status in broiler breeders

Li, K. X.; Wang, J. S.; Yuan, Dong; Zhao, Run; Wang, Y. X.; Zhan, Xiuan

doi:10.5713/ajas.18.0226

Cited by 23 publications

(17 citation statements)

References 26 publications

(25 reference statements)

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“…Selenium yeast supplementation also enhanced the Se status and antioxidant capacity. Consistent with other studies, Se content in plasma and tissues increased with a dose-dependent trends after Se supplementation [31,32]. After 6-week supplementation, plasma Se content in the SY0.45 group was recovered, suggesting that high dose Se supplementation may relieve the harmful effects caused by Se de ciency.…”

Section: Discussionsupporting

confidence: 90%

Transcriptome analysis revealed the effect of selenium yeast on improving eggshell quality in aged laying hens

Liu

Cao

et al. 2021

Preprint

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Background Egg internal and eggshell quality were deteriorated in aging laying hens. Improving egg and shell quality can prolong the laying cycle. Although, selenium yeast (SY) has been found with the potential to enhance the laying performance and egg quality, the underlying mechanisms have not been investigated. Therefore, we investigated the effect and molecule mechanism of selenium yeast on egg and shell quality in aged laying hens. Methods Three hundred 76-week-old Jing Hong laying hens were divided into four equal treatments and fed with Se-deficient diet (SD), 0.15, 0.30, 0.45 mg/kg selenium yeast diet (SY0.15, SY0.30 and SY0.45). At the end of the trial, we evaluated the plasma and tissue selenium content, plasma antioxidant capacity and egg quality. Transcriptomic analysis was performed to investigate the boosting effect of selenium yeast on eggshell quality. The weighted gene co-expression network analysis (WGCNA) analysis was performed to screen out the key candidate genes related with eggshell quality affected by selenium yeast. Results Dietary selenium yeast supplementation enhanced the eggshell strength (SY0.45) (P < 0.01) and reduced the shell translucence (SY0.15, SY0.30 and SY0.45) to ameliorate the eggshell quality. Moreover, body Se status and plasma antioxidant capacity were significantly enhanced by selenium yeast supplementation (P < 0.05), and showed a dose-dependent effect. Transcriptomic and WGCNA analysis identified some key candidate genes involved in eggshell quality including cell migration inducing hyaluronidase 1 (CEMIP), ovalbumin (OVAL), solute carrier family 6 member 17 (SLC6A17), solute carrier family 13 member 5 (SLC13A5), proopiomelanocortin (POMC) and proenkephalin (PENK). Functional enrichment analysis revealed that selenium may alter the biological process including eggshell mineralization, ion transport and laying period to affect eggshell formation. Conclusion Selenium yeast enhanced eggshell strength and reduced the shell translucence by improving antioxidant capacity, selenium status, and regulating the processes of shell mineralization, ion transport and laying period. These findings provide a novel molecule biomarker for affecting eggshell quality regulated by selenium.

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Section: Discussionsupporting

confidence: 90%

Transcriptome analysis revealed the effect of selenium yeast on improving eggshell quality in aged laying hens

Liu

Cao

et al. 2021

Preprint

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“…SeMet supplementation is reported to increase the expression and activity selenium-dependent endogenous peroxidase systems [46]. In confirmation of this, we demonstrated that compared to controls, dietary supplementation with SeMet significantly increased the overall peroxidase activity within whole mouse blood, as determined by luminol luminescence following PMA stimulation.…”

Section: Resultssupporting

confidence: 84%

Selenomethionine supplementation reduces lesion burden, improves vessel function and modulates the inflammatory response within the setting of atherosclerosis

et al. 2020

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Atherosclerosis is a chronic inflammatory disease of the vasculature characterised by the infiltration of activated neutrophils and macrophages at sites of damage within the vessel wall, which contributes to lesion formation and plaque progression. Selenomethionine (SeMet) is an organic form of selenium (Se), an essential trace element that functions in the regulation of the immune response by both bolstering the endogenous thioredoxin and glutathione antioxidant defence systems and by directly scavenging damaging oxidant species. This study evaluated the effect of dietary SeMet supplementation within a high fat diet fed apolipoprotein E deficient (ApoE−/-) mouse model of atherosclerosis. Dietary supplementation with SeMet (2 mg/kg) increased the tissue concentration of Se, and the expression and activity of glutathione peroxidase, compared to non-supplemented controls. Supplementation with SeMet significantly reduced atherosclerotic plaque formation in mouse aortae, resulted in a more stable lesion phenotype and improved vessel function. Concurrent with these results, SeMet supplementation decreased lesion accumulation of M1 inflammatory type macrophages, and decreased the extent of extracellular trap release from phorbol myristate acetate (PMA)-stimulated mouse bone marrow-derived cells. Importantly, these latter results were replicated within ex-vivo experiments on cultured neutrophils isolated from acute coronary syndrome patients, indicating the ability of SeMet to alter the acute inflammatory response within a clinically-relevant setting. Together, these data highlight the potential beneficial effect of SeMet supplementation as a therapeutic strategy for atherosclerosis.

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“…The pharmacokinetic profiles of Se compounds revealed that SeMet contributed to greater systemic exposure than selenite and MeSeCys (Evans et al., 2019). Administration of SeMet resulted in higher levels of Se deposition in serum, liver, kidney, pancreas, and muscle than administration of selenite and Se‐enriched yeast in broiler breeders (Li et al., 2018). The assays performed in Caenorhabditis elegans revealed that Se had a remarkable species‐dependent difference in bioavailability and toxicity.…”

Section: Selenium Species In Cereals and Human Healthmentioning

confidence: 99%

Selenium in cereals: Insight into species of the element from total amount

Xie

Sun

et al. 2021

Comp Rev Food Sci Food Safe

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Selenium (Se) is a trace mineral micronutrient essential for human health. The diet is the main source of Se intake. Se‐deficiency is associated with many diseases, and up to 1 billion people suffer from Se‐deficiency worldwide. Cereals are considered a good choice for Se intake due to their daily consumption as staple foods. Much attention has been paid to the contents of Se in cereals and other foods. Se‐enriched cereals are produced by biofortification. Notably, the gap between the nutritional and toxic levels of Se is fairly narrow. The chemical structures of Se compounds, rather than their total contents, contribute to the bioavailability, bioactivity, and toxicity of Se. Organic Se species show better bioavailability, higher nutritional value, and less toxicity than inorganic species. In this paper, we reviewed the total content of Se in cereals, Se speciation methods, and the biological effects of Se species on human health. Selenomethionine (SeMet) is generally the most prevalent and important Se species in cereal grains. In conclusion, Se species should be considered in addition to the total Se content when evaluating the nutritional and toxic values of foods such as cereals.

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Effects of different selenium sources and levels on antioxidant status in broiler breeders

Cited by 23 publications

References 26 publications

Transcriptome analysis revealed the effect of selenium yeast on improving eggshell quality in aged laying hens

Transcriptome analysis revealed the effect of selenium yeast on improving eggshell quality in aged laying hens

Selenomethionine supplementation reduces lesion burden, improves vessel function and modulates the inflammatory response within the setting of atherosclerosis

Selenium in cereals: Insight into species of the element from total amount

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