Effects of Different Levels of Food Restriction on Passive-Avoidance Memory and The Expression of Synapsin I in Young Mice

Deng, Liyu; Wu, Zhou; Han, Pengcheng

doi:10.1080/00207450802328250

Cited by 12 publications

(13 citation statements)

References 30 publications

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“…Although, in this study, resveratrol was used as a caloric restriction mimetic to stimulate caloric restriction, the results obtained on the effect of resveratrol as CR mimetic on memory of mice were in corroboration with the findings of Deng et al [26] who reported no significant change in short-term memory of mice using the passive avoidance test for memory after subjecting mice to a 20% caloric restriction for one month. However, no uniform conclusion has been reached on the effect of caloric restriction or caloric restriction-like effects on cognitive functions in young animals.…”

Section: Discussionsupporting

confidence: 78%

“…Nevertheless, some investigators have suggested that caloric restriction enhanced learning and memory in young animals [27,41,42], while others reported the contrary [28,43]. This discrepancy was attributed to several factors including differences in caloric restriction treatment, duration of caloric restriction, species or strain of animal, and type of behavioural test [26].…”

Section: Discussionmentioning

confidence: 89%

“…However, numerous works have been done on EE, CR, and its mimetics such as resveratrol and sulforaphane [1,24], and much attention has been lavished on the effect of resveratrol, CR, and EE on aging and age related disorders but the possible beneficial role in young healthy animals has not been investigated. The beneficial role of CR in the nervous system has been extensively studied in aged animals [26]. Moreover, several reports showed the physiological, neurological, and behavioural effects of CR and EE in rodents, but the majority of efforts have been focused on the beneficial effects of CR and EE on aging and lifespan in the past decades, and little attention has been paid to the physiological effects of CR and EE especially in young healthy animals.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Resveratrol as Caloric Restriction Mimetic and Environmental Enrichment on Neurobehavioural Responses in Young Healthy Mice

Muhammad

Magaji

Mohammed

et al. 2014

Advances in Neuroscience

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Caloric restriction and environmental enrichment have been separately reported to possess health benefits such as improvement in motor and cognitive functions. Resveratrol, a natural polyphenolic compound, has been reported to be caloric restriction mimetic. This study therefore aims to investigate the potential benefit of the combination of resveratrol as CR and EE on learning and memory, motor coordination, and motor endurance in young healthy mice. Fifty mice of both sexes were randomly divided into five groups of 10 animals each: group I animals received carboxymethylcellulose (CMC) orally per kg/day (control), group II animals were maintained on every other day feeding, group III animals received resveratrol 50 mg/kg, suspended in 10 g/L of (CMC) orally per kg/day, group IV animals received CMC and were kept in an enriched environment, and group V animals received resveratrol 50 mg/kg and were kept in EE. The treatment lasted for four weeks. On days 26, 27, and 28 of the study period, the animals were subjected to neurobehavioural evaluation. The results obtained showed that there was no significant change ( > 0.05) in neurobehavioural responses in all the groups when compared to the control which indicates that 50 mg/kg of resveratrol administration and EE have no significant effects on neurobehavioural responses in young healthy mice over a period of four weeks.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Resveratrol as Caloric Restriction Mimetic and Environmental Enrichment on Neurobehavioural Responses in Young Healthy Mice

Muhammad

Magaji

Mohammed

et al. 2014

Advances in Neuroscience

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“…There are, nevertheless, alternative explanations of the persistent CPP that cannot be ruled out at this time. For example, food restriction may enhance recall of the cocaine-context association (Hashimoto and Watanabe, 2005; Deng et al, 2009) or impair extinction learning or its expression (Koot et al, 2009). However, in both Experiments 1 and 3 food-restricted subjects were not only resistant to extinction of the CPP but displayed trends indicative of CPP sensitization.…”

Section: Discussionmentioning

confidence: 99%

Food restriction increases acquisition, persistence and drug prime-induced expression of a cocaine-conditioned place preference in rats

Zheng

Vaca

2012

Pharmacology Biochemistry and Behavior

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Cocaine conditioned place preference (CPP) is more persistent in food-restricted than ad libitum fed rats. This study assessed whether food restriction acts during conditioning and/or expression to increase persistence. In Experiment 1, rats were food-restricted during conditioning with a 7.0 mg/kg (i.p.) dose of cocaine. After the first CPP test, half of the rats were switched to ad libitum feeding for three weeks, half remained on food restriction, and this was followed by CPP testing. Rats tested under the ad libitum feeding condition displayed extinction by the fifth test. Their CPP did not reinstate in response to overnight food deprivation or a cocaine prime. Rats maintained on food restriction displayed a persistent CPP. In Experiment 2, rats were ad libitum fed during conditioning with the 7.0 mg/kg dose. In the first test only a trend toward CPP was displayed. Rats maintained under the ad libitum feeding condition did not display a CPP during subsequent testing and did not respond to a cocaine prime. Rats tested under food-restriction also did not display a CPP, but expressed a CPP following a cocaine prime. In Experiment 3, rats were ad libitum fed during conditioning with a 12.0 mg/kg dose. After the first test, half of the rats were switched to food restriction for three weeks. Rats that were maintained under the ad libitum condition displayed extinction by the fourth test. Their CPP was not reinstated by a cocaine prime. Rats tested under food-restriction displayed a persistent CPP. These results indicate that food restriction lowers the threshold dose for cocaine CPP and interacts with a previously acquired CPP to increase its persistence. In so far as CPP models Pavlovian conditioning that contributes to addiction, these results suggest the importance of diet and the physiology of energy balance as modulatory factors.

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“…Immunoreactivity for synapsin I increase during LTP (Sato et al 2000); Likewise, spatial learning in the Morris water maze induced synapsin I mRNA and protein expression (Gomez-Pinilla et al 2001). Moreover, absence of synapsin I resulted in the decrease of vesicular transport of specific neurotransmitters in mice brain (Bogen et al 2006(Bogen et al , 2009 In a recent report by Deng et al (2009) it was shown that gene expression of synapsin I in mice brain was up-regulated by 4 weeks of 20% food restriction, which also significantly improved the memory of mice, whereas, synapsin I gene expression was down-regulated by 60 and 80% food restriction with no effect on memory. These results are in agreement with our present findings that DR reverses the age-related decline in the levels of synapsin 1 in old rats.…”

Section: Late-onset Dr Enhance Cellular Stress Response and Preservesmentioning

confidence: 95%

Late-onset dietary restriction compensates for age-related increase in oxidative stress and alterations of HSP 70 and synapsin1 protein levels in male Wistar rats

et al. 2009

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Numerous reports implicate increased oxidative stress in the functional and structural changes occurring in the brain and other organs as a part of the normal aging process. Dietary restriction (DR) has long been shown to be life-prolonging intervention in several species. This study was aimed to assess the potential efficacy of late-onset short term DR when initiated in 21 months old male wistar rats for 3 months on the antioxidant defense system and lipid peroxidation, cellular stress response protein HSP 70 and synaptic marker protein synapsin 1 in discrete brain regions such as cortex, hypothalamus, and hippocampus as well as liver, kidney and heart from 24 month old rats. Age-associated decline in activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione, and elevated levels of lipid peroxidation was observed in brain and peripheral organ as well as increased expression of HSP 70 and reduction in synapsin 1 was observed in brain studied. Late-onset short term DR was effective in partially restoring the antioxidant status and in decreasing lipid peroxidation level as well as enhancing the expression of HSP 70 and synapsin 1 in aged rats. Late onset short term DR also prevented age-related neurodegeneration as revealed by Fluoro-Jade B staining in hippocampus and cortex regions of rat brain. Thus our current results suggest that DR initiated even in old age has the potential to improve age related decline in body functions.

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Effects of Different Levels of Food Restriction on Passive-Avoidance Memory and The Expression of Synapsin I in Young Mice

Cited by 12 publications

References 30 publications

Effect of Resveratrol as Caloric Restriction Mimetic and Environmental Enrichment on Neurobehavioural Responses in Young Healthy Mice

Effect of Resveratrol as Caloric Restriction Mimetic and Environmental Enrichment on Neurobehavioural Responses in Young Healthy Mice

Food restriction increases acquisition, persistence and drug prime-induced expression of a cocaine-conditioned place preference in rats

Late-onset dietary restriction compensates for age-related increase in oxidative stress and alterations of HSP 70 and synapsin1 protein levels in male Wistar rats

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