Effects of Different Levels of Molybdenum on Rumen Microbiota and Trace Elements Changes in Tissues from Goats

Zhou, Sihui; Zhang, Caiying; Xiao, Qingyang; Yu, Zhuang; Gu, Xiaorong; Yang, Fan; Xing, Chenghong; Hu, Guoliang

doi:10.1007/s12011-016-0706-3

Cited by 20 publications

(8 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bacteria in diverse habitats, including the gut microbiota, express molybdoenzymes (Zhang and Gladyshev, 2010;Zhou et al, 2016). Proteobacteria tend to encode the highest number of molybdoenzymes (Zhang and Gladyshev, 2010).…”

Section: Discussionmentioning

confidence: 99%

Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer

Zhu

Miyata

Winter

et al. 2019

Journal of Experimental Medicine

View full text Add to dashboard Cite

Chronic inflammation and gut microbiota dysbiosis, in particular the bloom of genotoxin-producing E. coli strains, are risk factors for the development of colorectal cancer. Here, we sought to determine whether precision editing of gut microbiota metabolism and composition could decrease the risk for tumor development in mouse models of colitis-associated colorectal cancer (CAC). Expansion of experimentally introduced E. coli strains in the azoxymethane/dextran sulfate sodium colitis model was driven by molybdoenzyme-dependent metabolic pathways. Oral administration of sodium tungstate inhibited E. coli molybdoenzymes and selectively decreased gut colonization with genotoxin-producing E. coli and other Enterobacteriaceae. Restricting the bloom of Enterobacteriaceae decreased intestinal inflammation and reduced the incidence of colonic tumors in two models of CAC, the azoxymethane/dextran sulfate sodium colitis model and azoxymethane-treated, Il10-deficient mice. We conclude that metabolic targeting of protumoral Enterobacteriaceae during chronic inflammation is a suitable strategy to prevent the development of malignancies arising from gut microbiota dysbiosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer

Zhu

Miyata

Winter

et al. 2019

Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…Antagonistic interactions of molybdenum with other microelements could contribute to effect of molybdenum nanoparticles in animals [26]. Analysis of liver composition, muscle tissues and brain of animals for 25 chemical elements has revealed significant changes related to three of them, i.e.…”

Section: Biochemical Blood Parameters Inmentioning

confidence: 99%

MORPHOLOGICAL AND BIOCHEMICAL PARAMETERS IN Wistar RATS INFLUENCED BY MOLYBDENUM AND ITS OXIDE NANOPARTICLES

Sizova¹,

Мирошников²,

Калашников³

2016

S-h. biol.

View full text Add to dashboard Cite

A b s t r a c t Despite widespread use of nanoparticles in industry and medicine, there is very little information about how the newly developed nanomaterials interact with biological objects. Certain properties of the Mo-containing nanoparticles (NPs) suggest their possible toxic effect on warmblooded animals. In this paper we compared the effect of Mo NPs (at 1 and 25 mg/kg) and its oxide MoO3 NPs (at 1.2 and 29 mg/kg), when administrated parenterally, on metabolic parameters and the exchange of chemical elements in Wistar laboratory rats. There, we assessed the red and white blood cell counts, the hemoglobin level, the activity of catalase (CAT) and superoxide dismutase (SOD) (for oxidative status), the ALT, AST, LDH, GGT, creatine kinase activity, blood creatinine, bilirubin and urea concentrations (for metabolic status) at days 1, 7 and 14. A day after Mo NPs and MoO 3 NPs administration the number of blood leukocyte lowered by 11.3 % (Р < 0.05) and 58.5 % (Р < 0.01), respectively. Also, a decrease in monocyte number by 18.9 (Р < 0.05), 41.9 (Р < 0.01), 51.7 (Р < 0.05) and 83.3 % (Р < 0.001) as depending on NPs chemical composition and doses was characteristic, though on day 14 a significant difference to control (54.5 %, Р < 0.05) was found only for MoO 3 NPs at a dose of 29 mg/kg. The number of thrombocytes was the highest on day 14 for the maximum dosage of both NPs leading to hindered blood microcirculation. The experiments also showed an increase in serum aminotransferases, GGT and LDH activity. In sum, we observed manifestations of oxidative stress, anemia and capillary-trophic insufficiency in the animals administrated with high doses of molybdenum and Mo oxide NPs. These signs were progressing and the most apparent for molybdenum oxide NPs. Given the comparable doses used, the molybdenum nanoparticles exhibit lower toxicity as compared to its oxide.

show abstract

“…Molybdenum (Mo) is an essential beneficial trace element for humans, animals, and plants [6,7]. China has abundant Mo resources.…”

Section: Introductionmentioning

confidence: 99%

Effect of Molybdenum on Plant Physiology and Cadmium Uptake and Translocation in Rape (Brassica napus L.) under Different Levels of Cadmium Stress

Han

Wang

Wan

et al. 2020

IJERPH

View full text Add to dashboard Cite

This study investigated the beneficial effect of molybdenum (Mo) application on rape plants (Brassica napus L.) grown in a soil polluted by cadmium (Cd). A pot experiment was conducted to determine how different concentrations of exogenous Mo (0, 50, 100, and 200 mg/kg) affect plant physiology, biomass, photosynthesis, cation uptake, and Cd translocation and enrichment in rape plants under Cd stress (0.5 and 6.0 mg/kg). Under single Cd treatment, plant physiological and biochemical parameters, biomass parameters, leaf chlorophyll fluorescence parameters, and macroelement uptake of rape plants decreased, while their malonaldehyde content, proline content, non-photochemical quenching coefficient, and Cd uptake significantly increased, compared to those of the control group (p-values < 0.05). High-Cd treatment resulted in much larger changes in these parameters than low-Cd treatment. Following Mo application, the accumulation of malondialdehyde and proline decreased in the leaves of Cd-stressed plants; reversely, the contents of soluble protein, soluble sugar, and chlorophyll, and the activities of superoxide dismutase and glutathione peroxidase, all increased compared to those of single Cd treatment (p-values < 0.05). Exogenous Mo application promoted shoot and root growth of Cd-stressed plants in terms of their length, fresh weight, and dry weight. The negative effect of Cd stress on leaf chlorophyll fluorescence was substantially mitigated by applying Mo. Exogenous Mo also improved the uptake of inorganic cations, especially potassium (K+), in Cd-stressed plants. After Mo application, Cd uptake and accumulation were inhibited and Cd tolerance was enhanced, but Cd translocation was less affected in Cd-stressed plants. The mitigation effect of Mo on Cd stress in rape was achieved through the immobilization of soil Cd to reduce plant uptake, and improvement of plant physiological properties to enhance Cd tolerance. In conclusion, exogenous Mo can effectively reduce Cd toxicity to rape and the optimal Mo concentration was 100 mg/kg under the experimental conditions.

show abstract

Effects of Different Levels of Molybdenum on Rumen Microbiota and Trace Elements Changes in Tissues from Goats

Cited by 20 publications

References 30 publications

Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer

Editing of the gut microbiota reduces carcinogenesis in mouse models of colitis-associated colorectal cancer

MORPHOLOGICAL AND BIOCHEMICAL PARAMETERS IN Wistar RATS INFLUENCED BY MOLYBDENUM AND ITS OXIDE NANOPARTICLES

Effect of Molybdenum on Plant Physiology and Cadmium Uptake and Translocation in Rape (Brassica napus L.) under Different Levels of Cadmium Stress

Contact Info

Product

Resources

About