Effects of different fluid shear stress patterns on the in vitro degradation of poly(lactide‐co‐glycolide) acid membranes

Chu, Zhaowei; Li, Xiaoming; Y, Li; Zheng, Qingyuan; Feng, Chenglong; Ding, Xia; Feng, Wentao; Gao, Yuanming; Yao, Jie; Chen, Xiaofang; Wang, Lizhen; Fan, Yubo

doi:10.1002/jbm.a.35860

Cited by 20 publications

(10 citation statements)

References 56 publications

(69 reference statements)

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“…1 , which consists of one circulating system and a tensile load providing device. The testing platform was described in detail in our previous studies [ 22 , 23 ]. The Dulbecco's modified Eagle's medium (DMEM) was used as the simulated body fluid with an original pH value of 7.4 ± 0.1.…”

Section: Methodsmentioning

confidence: 99%

The effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applications

Wenxin

et al. 2018

Bioactive Materials

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Magnesium alloys have gained great attention as biodegradable materials for stent applications. Cardiovascular stents are continuously exposed to different types of mechanical loadings simultaneously during service, including tensile, compressive and fluid shear stress. In this study, the in vitro degradation of WE43 wires was investigated under combined effect of tensile loading and fluid shear stress and compared with that experienced an individual loading condition. For the individual mechanical loading treatment, the degradation of magnesium wires was more severely affected by tensile loading than fluid shear stress. Under tensile loading, magnesium wires showed faster increment of corrosion rates, loss of mechanical properties and localized corrosion morphology with the increasing tensile loadings. With the combined stress, smaller variation of the corrosion rates as well as the slower strength degeneration was shown with increasing stress levels, in comparison with the individual treatment of tensile loading. This study could help to understand the effect of complex stress condition on the corrosion of magnesium for the optimization of biodegradable magnesium stents.

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Section: Methodsmentioning

confidence: 99%

The effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applications

Wenxin

et al. 2018

Bioactive Materials

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“…200 , 201 Of note, biomechanical stimulation can also affect the degradation and release properties of PLA and PLGA polymers. 202 – 204 …”

Section: Insoluble Cuesmentioning

confidence: 99%

Biomimetic delivery of signals for bone tissue engineering

et al. 2018

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Bone tissue engineering is an exciting approach to directly repair bone defects or engineer bone tissue for transplantation. Biomaterials play a pivotal role in providing a template and extracellular environment to support regenerative cells and promote tissue regeneration. A variety of signaling cues have been identified to regulate cellular activity, tissue development, and the healing process. Numerous studies and trials have shown the promise of tissue engineering, but successful translations of bone tissue engineering research into clinical applications have been limited, due in part to a lack of optimal delivery systems for these signals. Biomedical engineers are therefore highly motivated to develop biomimetic drug delivery systems, which benefit from mimicking signaling molecule release or presentation by the native extracellular matrix during development or the natural healing process. Engineered biomimetic drug delivery systems aim to provide control over the location, timing, and release kinetics of the signal molecules according to the drug’s physiochemical properties and specific biological mechanisms. This article reviews biomimetic strategies in signaling delivery for bone tissue engineering, with a focus on delivery systems rather than specific molecules. Both fundamental considerations and specific design strategies are discussed with examples of recent research progress, demonstrating the significance and potential of biomimetic delivery systems for bone tissue engineering.

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“…5 . Subsequently, the effect of different patterns of fluid shear stress on the degradation was investigated [ 95 ]. Steady, sinusoid and squarewave fluid shear stress with the same average magnitude and the different maximum fluid shear stress and ‘window’ of effectiveness were applied.…”

Section: Effects Of Mechanical Loadsmentioning

confidence: 99%

The effect of mechanical loads on the degradation of aliphatic biodegradable polyesters

Liu

Chu

et al. 2017

Regenerative Biomaterials

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Aliphatic biodegradable polyesters have been the most widely used synthetic polymers for developing biodegradable devices as alternatives for the currently used permanent medical devices. The performances during biodegradation process play crucial roles for final realization of their functions. Because physiological and biochemical environment in vivo significantly affects biodegradation process, large numbers of studies on effects of mechanical loads on the degradation of aliphatic biodegradable polyesters have been launched during last decades. In this review article, we discussed the mechanism of biodegradation and several different mechanical loads that have been reported to affect the biodegradation process. Other physiological and biochemical factors related to mechanical loads were also discussed. The mechanical load could change the conformational strain energy and morphology to weaken the stability of the polymer. Besides, the load and pattern could accelerate the loss of intrinsic mechanical properties of polymers. This indicated that investigations into effects of mechanical loads on the degradation should be indispensable. More combination condition of mechanical loads and multiple factors should be considered in order to keep the degradation rate controllable and evaluate the degradation process in vivo accurately. Only then can the degradable devise achieve the desired effects and further expand the special applications of aliphatic biodegradable polyesters.

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Effects of different fluid shear stress patterns on the in vitro degradation of poly(lactide‐co‐glycolide) acid membranes

Cited by 20 publications

References 56 publications

The effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applications

The effect of tensile and fluid shear stress on the in vitro degradation of magnesium alloy for stent applications

Biomimetic delivery of signals for bone tissue engineering

The effect of mechanical loads on the degradation of aliphatic biodegradable polyesters

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