Effects of different fatty acids composition of phosphatidylcholine on brain function of dementia mice induced by scopolamine

Zhou, Miaomiao; Xue, Yong; Sun, Siyuan; Wen, Min; Li, Zhaojie; Xu, Jie; Wang, Jingfeng; Yanagita, Teruyoshi; Wang, Yuming; Xue, Changhu

doi:10.1186/s12944-016-0305-5

Cited by 50 publications

(30 citation statements)

References 51 publications

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“…A previous study showed that garlic extracts effect Aβ-induced cytoxicity in neuron-like PC12 cells (Zhou et al, 2016); however, in this study, oxidative and cholinergic effects were not investigated. The scopolamine-induced mouse model was used in the present study because it is a well-known animal model of experimental Alzheimer’s disease (Kim et al, 2012) and provides a good and relevant example of cholinergic dysfunction; scopolamine induces memory impairment, decreases the activities of anti-oxidative enzymes such as GPx, and increases levels of lipid peroxidant, MDA, in the brain (Budzynska et al, 2015).…”

Section: Discussionmentioning

confidence: 85%

Effect of Aged Garlic Ethyl Acetate Extract on Oxidative Stress and Cholinergic Function of Scopolamine-Induced Cognitive Impairment in Mice

Kim

2019

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This study was performed to investigate the effect of aged black garlic ethyl acetate extract on scopolamine-induced cognitive impairment in mice. Aged garlic ethyl acetate extract (BG) was administrated at a dose of 25 or 50 mg/ kg in scopolamine-induced mice. Cognitive ability was evaluated using a Morris water maze test and a passive avoidance test. BGs (50 mg/kg) shortened the latency time that was increased by scopolamine and increased the platform crossing numbers that was significantly shortened by scopolamine after 5 days training in the Morris water maze test (P<0.05). BG (50 mg/kg) also significantly prolonged the latency time in the passive avoidance test (P<0.05). Result from biochemical analysis showed that BG increased levels of glutathione, glutathione peroxidase activity, and glutathione reductase activity, whereas BG significantly inhibited lipid peroxidation (P<0.05). BG also attenuated cholinergic degradation through inhibiting acetylcholinesterase activity and increasing choline acetyltransferase activity (P<0.05). In conclusion, BG protected against scopolamine-induced cognitive impairment through decreasing oxidative damage and regulating cholinergic function in the brains of mice. BG may therefore be a beneficial food for protecting against neurodegeneration such as Alzheimer’s disease.

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Section: Discussionmentioning

confidence: 85%

Effect of Aged Garlic Ethyl Acetate Extract on Oxidative Stress and Cholinergic Function of Scopolamine-Induced Cognitive Impairment in Mice

Kim

2019

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“…In the aged human, the plasma level of phosphatidylcholine was positively correlated with cognitive flexibility within the prefrontal cortex and the decreased plasma level of phosphatidylcholine was observed in Alzheimer's disease (AD) patients [20]. Dietary supplementation with phosphatidylcholine improved brain function, such as learning and memory, and conferred increased resistance to oxidative stress by modulating the activity of SOD in mice [21]. In rat adrenal pheochromocytoma cells, treatment with phosphatidylcholine hydroperoxides enhanced the activities of antioxidant genes, including CAT, SOD, and glutathione peroxidase [22].…”

Section: Introductionmentioning

confidence: 99%

Phosphatidylcholine Extends Lifespan via DAF-16 and Reduces Amyloid-Beta-Induced Toxicity inCaenorhabditis elegans

Kim

Park

2019

Oxidative Medicine and Cellular Longevity

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Phosphatidylcholine is one of the major phospholipids comprising cellular membrane and is known to have several health-promoting activities, including the improvement of brain function and liver repair. In this paper, we examine the in vivo effect of dietary supplementation with phosphatidylcholine on the response to environmental stressors and aging in C. elegans. Treatment with phosphatidylcholine significantly increased the survival of worms under oxidative stress conditions. However, there was no significant difference in response to stresses caused by heat shock or ultraviolet irradiation. Oxidative stress is believed to be one of the major causal factors of aging. Then, we examined the effect of phosphatidylcholine on lifespan and age-related physiological changes. Phosphatidylcholine showed a lifespan-extending effect and a reduction in fertility, possibly as a tradeoff for long lifespan. Age-related decline of motility was also significantly delayed by supplementation with phosphatidylcholine. Interestingly, the expressions of well-known longevity-assuring genes, hsp-16.2 and sod-3, were significantly upregulated by dietary intervention with phosphatidylcholine. DAF-16, a transcription factor modulating stress response genes, was accumulated in the nucleus by phosphatidylcholine treatment. Increase of the ROS level with phosphatidylcholine suggests that the antioxidant and lifespan-extending effects are due to the hormetic effect of phosphatidylcholine. Phosphatidylcholine also showed a protective effect against amyloid beta-induced toxicity in Alzheimer’s disease model animals. Experiments with long-lived mutants revealed that the lifespan-extending effect of phosphatidylcholine specifically overlapped with that of reduced insulin/IGF-1-like signaling and required DAF-16. These findings showed the antioxidant and antiaging activities of phosphatidylcholine for the first time in vivo. Further studies focusing on the identification of underlying cellular mechanisms involved in the antiaging effect will increase the possibility of using phosphatidylcholine for the development of antiaging therapeutics.

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“…Scopolamine (SCO), a non-selective muscarinic acetylcholine receptor antagonist, is known to interfere with cholinergic transmission in the brain ( 1 , 2 ). Recently, we have reported that the SCO-induced dysregulation of cholinergic activity in the hippocampus leads to interference in processes of learning and memory in mice ( 3 – 5 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of chronic scopolamine treatment on cognitive impairment and neurofilament expression in the mouse hippocampus

et al. 2017

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Neurofilaments (NFs) including neurofilament-200 kDa (NF-H), neurofilament-165 kDa (NF-M) and neurofilament-68 kDa (NF-L) are major protein constituents of the brain, and serve important roles in the regulation of axonal transport. NF alteration is a key feature in the pathogenesis of neurological disorders involving cognitive dysfunction. In the present study, cognitive impairments were investigated, via assessments using the Morris water maze and passive avoidance tests, in mice following chronic systemic treatment with 1 mg/kg scopolamine (SCO) for 4 weeks. SCO-induced cognitive impairments were significantly observed 1 week following the SCO treatment, and these cognitive deficits were maintained for 4 weeks. However, the NF immunoreactivities and levels were altered differently according to the hippocampal subregion following SCO treatment. NF-H immunoreactivity and levels were markedly altered in all hippocampal subregions, and were significantly increased 1 week following the SCO treatment; thereafter, the immunoreactivity and levels significantly decreased with time. NF-M immunoreactivity and levels gradually decreased in the hippocampus and were significantly decreased 4 weeks following SCO treatment. NF-L immunoreactivity and levels gradually decreased in the hippocampus, and were significantly decreased 2 and 4 weeks following SCO treatment. In conclusion, the results of the present study demonstrated that chronic systemic treatment with SCO induced cognitive impairment from 1 week following SCO treatment, and NF expression was diversely altered according to the hippocampal subregion from 1 week following SCO treatment. These results suggest that SCO-induced changes in NF expression may be associated with cognitive impairment.

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Effects of different fatty acids composition of phosphatidylcholine on brain function of dementia mice induced by scopolamine

Cited by 50 publications

References 51 publications

Effect of Aged Garlic Ethyl Acetate Extract on Oxidative Stress and Cholinergic Function of Scopolamine-Induced Cognitive Impairment in Mice

Effect of Aged Garlic Ethyl Acetate Extract on Oxidative Stress and Cholinergic Function of Scopolamine-Induced Cognitive Impairment in Mice

Phosphatidylcholine Extends Lifespan via DAF-16 and Reduces Amyloid-Beta-Induced Toxicity inCaenorhabditis elegans

Effects of chronic scopolamine treatment on cognitive impairment and neurofilament expression in the mouse hippocampus

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