Effects of different anti‐asthmatic agents on induced sputum and eosinophil cationic protein in mild asthmatics

Başyiğit, İlknur; Yıldız, Füsun; Özkara, Sevgiye Kaçar; Boyacı, Haşim; Ilgazlı, Ahmet; Özkarakaş, Oktay

doi:10.1111/j.1440-1843.2004.00631.x

Cited by 12 publications

(26 citation statements)

References 30 publications

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“…Three thousand seven hundred and twenty‐eight patients from 16 studies (12, 14–16, 18–24, 26–28, 31, 32) were considered for this analysis (1833 treated with ICS, 1895 treated with LTRA). ICS was significantly superior to LTRA therapy in improving FEV 1 in absolute value (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Sixty patients from two studies (12,19) were considered for this analysis (29 treated with ICS, 31 treated with LTRA). ICS was similar to LTRA therapy in decreasing percentage of peripheral blood eosinophils ( Fig.…”

Section: Percentage Changes From Baseline In Peripheral Blood Eosinopmentioning

confidence: 99%

“…Two hundred and thirty-three patients from five studies (11,12,22,23,31) were considered for this analysis (116 treated with ICS, 117 treated with LTRA). Moderate level of heterogeneity was found (I 2 = 51%), so we chose the random effects models to analyse them.…”

Section: Percentage Changes From Baseline In Induced Sputum Eosinophimentioning

confidence: 99%

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Comparison of inhaled corticosteroids and leukotriene receptor antagonists in adolescents and adults with mild to moderate asthma: a meta‐analysis

Yang

Luo

Wang

et al. 2012

Clinical Respiratory J

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Twenty-four trials with 6197 randomized adolescents and adults with mild to moderate asthma met the inclusion criteria with a minimum duration of 4 weeks' treatment. Significant differences favouring ICS were found in all indices of pulmonary function. Other significant benefits of ICS were shown in symptoms, nocturnal awakenings, rescue-medication use, symptom-free days and quality of life. As to each special symptom of adverse effects, ICS was similar to LTRA in the incidence of headache, nausea and throat discomfort, but significantly higher in the incidence of hoarseness and oral pharyngeal candidiasis. Concerning withdrawal because of adverse events potentially related to treatment, ICS was similar to LTRA but significantly superior to LTRA in decreasing the asthma exacerbations or attacks during the treatment period. These results show that ICS may be the better drug in terms of efficacy and tolerability, except hoarseness and oral pharyngeal candidiasis, and should thus have priority over LTRA in asthma monotherapy in adolescents and adults.

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Section: Resultsmentioning

confidence: 99%

Section: Percentage Changes From Baseline In Peripheral Blood Eosinopmentioning

confidence: 99%

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Comparison of inhaled corticosteroids and leukotriene receptor antagonists in adolescents and adults with mild to moderate asthma: a meta‐analysis

Yang

Luo

Wang

et al. 2012

Clinical Respiratory J

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“…Evaluation and continued monitoring of eosinophil and ECP may be a way to assess efficacy of asthma therapy and airway inflammation in children with allergic asthma [58]. Both leukotriene receptor antagonists and inhaled corticosteroids have been associated with a reduction in sputum ECP levels in patients with mild to moderate persistent asthma [59,60]. A response of serum ECP levels to glucocorticoid treatment has also been observed [61].…”

Section: Eosinophil Cationic Proteinmentioning

confidence: 99%

Asthma in Children and Adolescents: A Comprehensive Approach to Diagnosis and Management

Chang

2011

Clinic Rev Allerg Immunol

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Asthma is a chronic disease that has a significant impact on quality of life and is particularly important in children and adolescents, in part due to the higher incidence of allergies in children. The incidence of asthma has increased dramatically during this time period, with the highest increases in the urban areas of developed countries. It seems that the incidence in developing countries may follow this trend as well. While our knowledge of the pathophysiology of asthma and the available of newer, safer medication have both improved, the mortality of the disease has undergone an overall increase in the past 30 years. Asthma treatment goals in children include decreasing mortality and improving quality of life. Specific treatment goals include but are not limited to decreasing inflammation, improving lung function, decreasing clinical symptoms, reducing hospital stays and emergency department visits, reducing work or school absences, and reducing the need for rescue medications. Non-pharmacological management strategies include allergen avoidance, environmental evaluation for allergens and irritants, patient education, allergy testing, regular monitoring of lung function, and the use of asthma management plans, asthma control tests, peak flow meters, and asthma diaries. Achieving asthma treatment goals reduces direct and indirect costs of asthma and is economically cost-effective. Treatment in children presents unique challenges in diagnosis and management. Challenges in diagnosis include consideration of other diseases such as viral respiratory illnesses or vocal cord dysfunction. Challenges in management include evaluation of the child's ability to use inhalers and peak flow meters and the management of exercise-induced asthma.

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“…No unpublished studies met the criteria for inclusion in this review. The 37 articles were assessed for risk of bias [11], and six articles had a low risk of bias [43,57,70,[75][76][77], 17 had an unclear risk of bias [42,46,47,52,53,55,56,58,61,[63][64][65][66]69,[71][72][73], and 14 had a high risk of bias [41,44,45,[48][49][50][51]54,59,60,62,67,68,74]. Detailed results for the risk of bias assessment of each article can be found in Supporting Information S1.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of inhaled corticosteroids for patients with asthma: a descriptive review of randomized controlled trials

Alabousi

Ambeault³

et al. 2015

UOJM

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Objective: To evaluate the efficacy of inhaled corticosteroids (ICS) in patients with asthma based on changes in sputum eosinophil counts, through a review of relevant randomized controlled trials (RCTs).Methods: Studies were retrieved from MEDLINE, EMBASE, the SYSTEM FOR INFORMATION ON GREY LITERATURE, and the INSTITUTE FOR SCIENTIFIC INFORMATION from February 1, 2003 to February 1, 2013 based on a comprehensive search strategy. Articles were screened through two stages: title and abstract; and full-text screening. RCTs enrolling patients with asthma, testing an ICS intervention, and reporting outcomes on changes in sputum eosinophil counts pre- and post-intervention were included. Following screening, data extraction, and quality appraisal, a descriptive synthesis of trials was conducted.Results: The search strategy retrieved 447 articles, of which 66 articles underwent full-text screening, resulting in 37 RCTs that met the inclusion criteria for this review. The articles were stratified according to the type of ICS: budesonide, fluticasone propionate, ciclesonide, beclomethasone dipropionate, and mometasone. Across trials, 9 of 16 budesonide, 5 of 14 fluticasone propionate, 4 of 9 of nine ciclesonide, 2 of 4 beclomethasone dipropionate, and 1 of 2 mometasone interventions demonstrated a statistically significant (p < 0.05) reduction in sputum eosinophil counts.Conclusion: This study detected differences between ICS treatments however the clinical relevance is uncertain. There is insufficient evidence to suggest the superiority of one ICS treatment over another. Further research needs to be conducted to evaluate the relative impact of ICS products upon eosinophil counts, as well as in clarifying what quantitative level of change in baseline eosinophil counts is required to observe a change in symptom improvement and disease control.

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Effects of different anti‐asthmatic agents on induced sputum and eosinophil cationic protein in mild asthmatics

Cited by 12 publications

References 30 publications

Comparison of inhaled corticosteroids and leukotriene receptor antagonists in adolescents and adults with mild to moderate asthma: a meta‐analysis

Comparison of inhaled corticosteroids and leukotriene receptor antagonists in adolescents and adults with mild to moderate asthma: a meta‐analysis

Asthma in Children and Adolescents: A Comprehensive Approach to Diagnosis and Management

Efficacy of inhaled corticosteroids for patients with asthma: a descriptive review of randomized controlled trials

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