Effects of diets with different levels of fennel (Foeniculum vulgare) seed powder on DLK1 gene expression in brain, adipose tissue, femur muscle and rumen of Kermani lambs

Masoudzadeh, Seyed Hojat; Mohammadabadi, Mohammadreza; Khezri, A.; Stavetska, Ruslana; Oleshko, Valentyna; Babenko, Olena; Yemets, Zoya; Kalashnyk, Oleksandr

doi:10.1016/j.smallrumres.2020.106276

Cited by 57 publications

(43 citation statements)

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“…Our results collectively showed that all three Iranian local sheep breeds may have experience different evolutionary path based on genetic drift and various regional adaptation after domestication, which is in agreement with previous studies [ 8 , 39 , 40 ]. We then detected a number of candidate genes that previously have reported associated with production traits in sheep and other livestock species.…”

Section: Discussionsupporting

confidence: 93%

“…Around 44.9% of the world’s sheep populations are live in Asian continent [ 6 ], and Iran has the largest sheep population of 52 million in the Middle East. More than 27 sheep ecotypes have been recognized in Iran which are vary in different factors, including their genetic potential for milk, meat and wool production traits [ 7 , 8 ]. These breeds are conventionally named in accordance with their geographical origin, also thay have categorized according to productive performance and morphological features [ 9 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Signature selection analysis reveals candidate genes associated with production traits in Iranian sheep breeds

et al. 2021

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Background Sheep were among the first animals to be domesticated. They are raised all over the world and produce a major scale of animal-based protein for human consumption and play an important role in agricultural economy. Iran is one of the important locations for sheep genetic resources in the world. Here, we compared the Illumina Ovine SNP50 BeadChip data of three Iranian local breeds (Moghani, Afshari and Gezel), as a population that does not undergone artificial breeding programs as yet, and five other sheep breeds namely East Friesian white, East Friesian brown, Lacaune, DorsetHorn and Texel to detect genetic mechanisms underlying economical traits and daptation to harsh environments in sheep. Results To identify genomic regions that have been targeted by positive selection, we used fixation index (Fst) and nucleotide diversity (Pi) statistics. Further analysis indicated candidate genes involved in different important traits such as; wool production included crimp of wool (PTPN3, NBEA and KRTAP20–2 genes), fiber diameter (PIK3R4 gene), hair follicle development (LHX2 gene), the growth and development of fiber (COL17A1 gene)), adaptation to hot arid environments (CORIN gene), adaptive in deficit water status (CPQ gene), heat stress (PLCB4, FAM107B, NBEA, PIK3C2B and USP43 genes) in sheep. Conclusions We detected several candidate genes related to wool production traits and adaptation to hot arid environments in sheep that can be applicable for inbreeding goals. Our findings not only include the results of previous researches, but also identify a number of novel candidate genes related to studied traits. However, more works will be essential to acknowledge phenotype- genotype relationships of the identified genes in our study.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Signature selection analysis reveals candidate genes associated with production traits in Iranian sheep breeds

et al. 2021

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“…The Kermani sheep breed is one of the 27 breeds and ecotypes living in Iran, and animal management plays a key role in achieving the optimal genetic and phenotypic characteristics of this breed ( Masoudzadeh et al., 2020 ). The use phytobiotics and bioactive plants with antimicrobial growth promoters in animal feeding has been suggested to improve zootechnical output variables and to prevent the development of some types of diseases ( Aćimović et al., 2016 ).…”

Section: Introductionmentioning

confidence: 99%

“…In a previous study ( Masoudzadeh et al., 2020 ), we have also investigated the effects of various amounts of fennel on growth characteristics and on the expression of DLK1 in some tissues, including rumen muscle, femur muscle, adipose, and brain tissues in the Kermani sheep breed. Accordingly, the results of this study showed that enhancing the consumption of fennel in the diet causes a positive effect on the expression of DLK1 in both the rumen and femur muscle tissues.…”

Section: Introductionmentioning

confidence: 99%

“…According to previous studies, the effect of fennel and the role of DLK1 expression on testis, liver, and humeral muscle tissues of livestock, especially sheep, have not been reported in any study up to now. Therefore, in continuous with the previous research ( Masoudzadeh et al., 2020 ) and in order to develop and complete its findings, the current investigation was conducted to investigate the associations among the expression of DLK1 in humeral muscle, liver, and testis tissues, growth and selected biochemical traits, and fennel feeding in Kermani lamb.…”

Section: Introductionmentioning

confidence: 99%

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Fennel (Foeniculum vulgare) seed powder increases Delta-Like Non-Canonical Notch Ligand 1 gene expression in testis, liver, and humeral muscle tissues of growing lambs

Mohammadabadi

Masoudzadeh

Khezri

et al. 2021

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Delta-Like Non-Canonical Notch Ligand 1 (DLK1) is one of the key genes involved in the development of muscle, liver, pancreas, and lung cells; adipocytes production; and the improvement of digestion, growth performance, and meat quality. It has been documented that fennel is effective on increasing the DLK1 gene ( DLK1 ) expression in the testis, liver, and muscle tissues, which may consequently have important implications for sheep production. Hence, the aim of the current investigation was to evaluate the fennel seed powder's effect on DLK1 expression in testis, liver, and humeral muscle tissues in growing lambs. For the purpose of this study, 30 male Kermani sheep were fed with three different group of diets (number of animals in each group was 10), including control (without any fennel seed powder), treatment 1 (with 10 g/kg of dry matter (DM) fennel seed powder), and treatment 2 (with 20 g/kg of DM fennel seed powder) during a 3-month period. Thereafter, total RNA was extracted, cDNA was synthesized, and Real-Time PCR was performed. The addition of fennel seed powder (in the treatment 1 and treatment 2 groups) in the growing lambs diets consequently resulted in greater expression of DLK1 in both the liver and humeral muscle tissues compared to the testis tissue (P < 0.05). Furthermore, the increased DLK1 expression was higher in the tissue of humeral muscle (P < 0.05) in comparison to the other two tissues. As well, the concentration of blood testosterone was greater (P < 0.05) for the animals fed with fennel powder compared to growing lambs fed with the control diet. However, the concentrations of blood liver enzymes, including serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT), decreased by the addition of 10 g/kg DM fennel to diets of lambs compared to the control diet (no fennel). Therefore, it can be concluded that using fennel seed powder in the diet of growing lamb by affecting the expression of DLK1, can improve the concentrations of blood testosterone, SGOT, SGPT, and muscle structure (increased mass of muscle and size of muscle fiber).

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Circular RNA regulation of fat deposition and muscle development in cattle

Gao

Wang

et al. 2022

Veterinary Medicine & Sci

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Circular RNAs (circRNAs) are important transcriptional regulatory RNA molecule that can regulate the transcription of downstream genes by competitive binding of miRNAs or coding proteins or by blocking mRNAs translation. Numerous studies have shown that circRNAs are extensively involved in cell proliferation, differentiation and apoptosis, gene transcription and signal transduction. Fat deposition and muscle development have important effects on beef traits. CircRNAs are involved in regulating bovine fat and muscle cells and are differentially expressed in the tissues composed of these cells, suggesting that circRNAs play an important role in regulating bovine fat formation and muscle development. This review describes differential expression of circRNAs in bovine fat and muscle tissues, research progress in understanding how circRNAs regulate the proliferation and differentiation of bovine fat and muscle cells through competing endogenous RNAs networks, and provide a reference for the subsequent research on the molecular mechanism of circRNAs in regulating fat deposition and muscle development in cattle.

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Effects of diets with different levels of fennel (Foeniculum vulgare) seed powder on DLK1 gene expression in brain, adipose tissue, femur muscle and rumen of Kermani lambs

Cited by 57 publications

References 51 publications

Signature selection analysis reveals candidate genes associated with production traits in Iranian sheep breeds

Signature selection analysis reveals candidate genes associated with production traits in Iranian sheep breeds

Fennel (Foeniculum vulgare) seed powder increases Delta-Like Non-Canonical Notch Ligand 1 gene expression in testis, liver, and humeral muscle tissues of growing lambs

Circular RNA regulation of fat deposition and muscle development in cattle

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