Effects of Dietary β‐Cyclodextrin in Hypercholesterolaemic Rats

García-Mediavilla, Victoria; Villares, Carmen; Culebras, Jesús M.; Bayón, J.E.; González‐Gallego, Javier

doi:10.1034/j.1600-0773.2003.920206.x

Cited by 30 publications

(17 citation statements)

References 27 publications

(44 reference statements)

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“…Indeed inhibition of this enzyme in the liver by statins results in decreased cholesterol synthesis, increased LDL-R synthesis and consequent decreases in circulating levels of LDL and cholesterol [26,27]. In the present study, we found that the significantly increased hepatic HMG-CoA reductase mRNA expression levels in rats fed a high cholesterol diet were normalized by treatment with FPS.…”

Section: Discussionsupporting

confidence: 63%

“…The rate limiting enzyme of this process is CYP7α-1. Indeed increased CYP7α-1 has been demonstrated to hasten the rate of conversion of cholesterol to bile acids in hepatocytes [27,28]. In this study we found that the hepatic mRNA expression levels of CYP7α-1 were significantly elevated in rats treated with FPS as compared to those in the control and high cholesterol groups.…”

Section: Discussionsupporting

confidence: 57%

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Polysaccharide from Fuzi (FPS) Prevents Hypercholesterolemia in Rats

et al. 2010

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Background and aimPolysaccharide from fuzi (FPS), a Chinese herbal medicine extract, has been demonstrated to exert lipid lowering affects. In this study we examined potential mechanisms underlying this affect, specifically alterations in expression of the LDL-receptor (LDL-R), 3-hydroxy-3-methyl glutaryl (HMG)-CoA reductase and cytochrome P450 7α-1 (CYP7α-1), using a rat model of hypercholesterolemia.Methods and resultsMale rats were fed either a normal or high cholesterol (HC) diet for two-weeks. Half of the rats on the HC diet were orally gavaged with FPS (224 mg/kg, 448 mg/kg or 896 mg/kg diet) daily. Serum lipid levels were quantified at end of the study period as were liver levels of LDL-R protein and mRNA expression of CYP7α-1 and HMG-CoA. Serum cholesterol and LDL-C concentrations were significantly elevated from control in HC rats, but not in those treated with FPS (P < 0.05). LDL-R expression was significantly decreased in the HC group compared to control (P < 0.05), but significantly increased in the FPS group (P < 0.05). HMG-CoA mRNA levels were significantly increased in the HC group compared both other groups (P < 0.05), while CYP7α-1 expression was significantly higher in the FPS group compared to both other groups (P < 0.05).ConclusionThese findings suggest that the cholesterol lowering effect of FPS in hypercholesteremic rats is caused at least in part by increased hepatic LDL-R and CYP7α-1 expression and decreased HMG-CoA expression. Further study is needed to determine precisely where and how FPS exerts these effects. FPS offers potential as a therapeutic agent for the treatment of hypercholesterolemia.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionsupporting

confidence: 57%

Polysaccharide from Fuzi (FPS) Prevents Hypercholesterolemia in Rats

et al. 2010

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“…A HC diet induces a fatty liver, which means a status of hepatic damage [54]. In this study, the plasma AST and ALT activities (Table 6), a nonspecific and specific marker of hepatic parenchymal injury, respectively, corresponded with the results for the plasma total-C concentration.…”

Section: Discussionmentioning

confidence: 84%

Vitamin E supplementation alters HDL-cholesterol concentration and paraoxonase activity in rabbits fed high-cholesterol diet: Comparison with probucol

Jeon

Park

Kwon

et al. 2005

J. Biochem. Mol. Toxicol.

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Vitamin E and probucol are well-known antioxidants that prevent cells from the oxidative stress, which is a risk factor of atherosclerosis. Male rabbits were fed either 0.03% vitamin E or 0.05% probucol in a 0.5% high-cholesterol (HC) diet for 8 weeks. Vitamin E and probucol significantly suppressed an increase in plasma total-cholesterol (total-C) and low-density lipoprotein cholesterol compared to HC-control group. However, plasma high-density lipoprotein-cholesterol (HDL-C) and HDL-C/total-C ratio levels and plasma paraoxonase activity were only significantly higher in vitamin E group after 8 weeks. Hepatic ACAT activity was significantly lower in both vitamin E and probucol groups than in HC-control group, while HMG-CoA reductase activity was the highest only in the probucol group. Total fecal sterol content was significantly higher in probucol and vitamin E groups than in the two control groups. Some atherogenic signs were discovered in the aortic fatty streak of HC-control group, yet not in other groups. Hepatic mRNA expressions of apo B-100 and apo C-III were significantly lower in probucol group than in other groups. Vitamin E supplementation was found to alter the plasma HDL-C-related factors; meanwhile, probucol supplementation was very effective in enhancing cholesterol metabolism, except for a negative effect that reduced plasma HDL-C concentration.

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“…β‐CD is resistant to enzymes in the gastric and small intestine, hence it is not absorbed by the small intestine in rat or human. Many studies have been reported that β‐CD exhibited hypocholesterolemic effect in pigs (Ferezou et al., ), in hypercholesterolemic rats (García‐Mediavilla, Villares, Culebras, Báyon, & González‐Gallego, ), in genetically hypercholesterolemic rats, and in hamsters (Riottot et al., ). Owing to β‐CD has high encapsulation capability and not digestible in the small intestine, it acts as a cholesterol trap in the small intestine and hence inhibits the cholesterol absorption.…”

Section: Resultsmentioning

confidence: 99%