Effects of dietary zinc oxide nanoparticles supplementation on growth performance, zinc status, intestinal morphology, microflora population, and immune response in weaned pigs

Pei, Xiaolin; Zhang, Xiao; Liu, Lujie; Wang, Geng; Tao, Wenjing; Wang, Minqi; Zou, Junbiao; Leng, Dongbi

doi:10.1002/jsfa.9312

Cited by 83 publications

(60 citation statements)

References 39 publications

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“…The intestinal mucosa forms a monolayer of epithelial cells, performing the primary functions in digesting, absorbing of nutrients, and preventing luminal pathogens and toxic substances . Our present results indicated that Zn‐Met supplementation of 80 mg Zn/kilogram diet increased villus height, villus area, and villus height/crypt depth ratio and reduced crypt depth in the jejunum of laying hens compared with the control and ZnSO 4 groups.…”

Section: Discussionsupporting

confidence: 88%

“…Perhaps this is because more Zn can be absorbed through the gastrointestinal tract if there is high concentration of Zn in the diet. 16 In addition, it was observed that liver had the highest Zn content, followed by jejunum and finally duodenum in our study. Zn transport varies among tissues, which is a factor due to Zn metabolism.…”

Section: Discussionsupporting

confidence: 56%

“…In the current study, the result showed Zn contents in liver, duodenum, and jejunum were significantly enhanced by supplementation of Zn‐Met or ZnSO 4 compared with the control. Perhaps this is because more Zn can be absorbed through the gastrointestinal tract if there is high concentration of Zn in the diet . In addition, it was observed that liver had the highest Zn content, followed by jejunum and finally duodenum in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Sections of middle duodenum and middle jejunum (two layers per replication) were isolated and flushed with sterile saline solution. Part of the section (1 cm) isolated was fixed in 4% paraformaldehyde and kept at 4 °C for a microscopic assessment of mucosal morphology . Another part of the section (1 cm) isolated was collected (blood was washed with normal saline) and placed in liquid nitrogen.…”

Section: Methodsmentioning

confidence: 99%

“…Part of the section (1 cm) isolated was fixed in 4% paraformaldehyde and kept at 4 ∘ C for a microscopic assessment of mucosal morphology. 16 Another part of the section (1 cm) isolated was collected (blood was washed with normal saline) and placed in liquid nitrogen. About 2 g liver was removed and immediately frozen in liquid nitrogen for determination of Zn status.…”

Section: Sample Collectionsmentioning

confidence: 99%

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Effects of zinc methionine supplementation on laying performance, zinc status, intestinal morphology, and expressions of zinc transporters' mRNA in laying hens

Zhou

et al. 2019

J Sci Food Agric

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BACKGROUND This study was conducted to investigate effects of dietary zinc methionine (Zn‐Met) supplementation on laying performance, zinc (Zn) status, intestinal morphology, and Zn transporters in laying hens compared with zinc sulfate (ZnSO4). A total of 384 Hyline Grey laying hens (38 weeks old) with similar performance (1.42 ± 0.07 kg) were randomly allotted to four dietary treatments and fed with a basal diet (control) or the basal diet supplemented with Zn, either as Zn‐Met at 40 and 80 mg Zn/kilogram diet or as ZnSO4 at 80 mg Zn/kilogram diet, for 10 weeks. RESULTS There was no difference in egg weight, egg production, feed intake, and feed conversation ratio among all groups (P > 0.05). Compared with the control, Zn contents were increased (P < 0.05) in the liver, duodenum, and jejunum of laying hens fed diets supplemented with different Zn sources. There was no difference (P > 0.05) in Zn contents in liver, duodenum, and jejunum between diets supplemented with Zn‐Met or ZnSO4 at 80 mg Zn/kilogram diet. Compared with the control and the ZnSO4 group (80 mg Zn/kilogram diet), supplementation with Zn‐Met of 80 mg Zn/kilogram diet increased (P < 0.05) villus height, villus area, and villus height/crypt depth ratio but reduced (P < 0.05) crypt depth in jejunum. Expression of metallothionein messenger RNA of jejunum in the group fed a diet containing Zn‐Met (80 mg Zn/kilogram diet) was higher (P < 0.05) than that in the control. CONCLUSION These results indicated that Zn‐Met has positive effects on the Zn status of liver, duodenum, and jejunum, intestinal morphology, and metallothionein messenger RNA expression in jejunum of laying hens compared with ZnSO4. © 2019 Society of Chemical Industry

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Sample Collectionsmentioning

confidence: 99%

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Effects of zinc methionine supplementation on laying performance, zinc status, intestinal morphology, and expressions of zinc transporters' mRNA in laying hens

Zhou

et al. 2019

J Sci Food Agric

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Feed Additives in Swine Diets

O’Shea¹

2022

Sustainable Swine Nutrition

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Zinc citrate‐coated whey protein nanoparticles alleviate kidney damage and the disturbances in inflammatory gene expression in rats

El‐Nekeety

Hassan

Abdel-Aziem

et al. 2023

J Biochem & Molecular Tox

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This work was conducted to synthesize whey protein nanoparticles (WPNPs) for the coating of zinc citrate (Zn CITR) at three levels and to study their protective role against CCl4‐induced kidney damage and inflammatory gene expression disorder in rats. Seventy male Sprague‐Dawley rats were divided into seven groups and treated orally for 4 weeks as follows; the control group, the group treated twice a week with CCl4 (5 mL/kg b.w), the groups received CCl4 plus WPNPs (300 mg/kg b.w); the group received 50 mg/kg b.w of Zn CITR or the three formulas of Zn CITR‐WPNPs at low, medium and high doses (LD, MD, and HD). Blood and kidney samples were collected for different assays and histological analyses. The fabricated particles were semispherical, with an average size of 160 ± 2.7, 180 ± 3.1, and 200 ± 2.6 nm and ζ potential of −126, −93, and −84 mV for ZN CITR‐WPNPs (LD), Zn CITR‐WPNPs (MD), and ZN CITR‐WPNPs (HD), respectively. CCl4 significantly increased (p ≤ 0.05) kidney function indices, oxidative stress markers, messenger RNA expression of transforming growth factor‐β1, interleukin (IL)‐1β, IL‐10, IL‐6, inducible nitric oxide synthase, and tumor necrosis factor‐α and significantly decreased (p ≤ 0.05) renal superoxide dismutase, catalase, and glutathione peroxidase along with the histological changes in the kidney tissues. WPNPs, Zn CITR, and Zn CITR loaded WPNPS showed a protective effect against these complications and Zn CITR‐WPNPs (LD) was more effective. WPNPs can be used effectively for coating Zn CITR at a level of 7 mg/g WPNPs to be used as a supplement for the protection of the kidney against different toxicants to enhance immunity and avoid harm of excess Zn.

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Effects of dietary zinc oxide nanoparticles supplementation on growth performance, zinc status, intestinal morphology, microflora population, and immune response in weaned pigs

Cited by 83 publications

References 39 publications

Effects of zinc methionine supplementation on laying performance, zinc status, intestinal morphology, and expressions of zinc transporters' mRNA in laying hens

Effects of zinc methionine supplementation on laying performance, zinc status, intestinal morphology, and expressions of zinc transporters' mRNA in laying hens

Feed Additives in Swine Diets

Zinc citrate‐coated whey protein nanoparticles alleviate kidney damage and the disturbances in inflammatory gene expression in rats

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