Effects of dietary xylitol on collagen content and glycosylation in healthy and diabetic rats

Knuuttila, Matti; Kuoksa, T.H.; Svanberg, Martti; Mattila, Pauli T.; Karjalainen, Kaisa; Kolehmainen, Eila

doi:10.1016/s0024-3205(00)00621-4

Cited by 15 publications

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“…This is well in accordance with our previous fi ndings which showed that aged rats given a long-term dietary xylitol supplementation have signifi cantly greater trabecular bone volume as compared to age-matched controls that were not given xylitol [10] . The above also agrees with our fi ndings in diabetic rats showing that xylitol protects against the decrease caused by streptozotocin in the amount of acid-soluble collagen [12] . The mechanism behind the xylitol-induced effect on collagen synthesis is obscure, but a reduced redox state, which is produced during the metabolism of xylitol [18] , may be involved.…”

Section: Discussionsupporting

confidence: 92%

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Effects of a Long-Term Dietary Xylitol Supplementation on Collagen Content and Fluorescence of the Skin in Aged Rats

Mattila

Pelkonen²,

Knuuttila³

2005

Gerontology

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Background: Dietary xylitol has been shown to increase the amounts of newly synthesized collagen, and to decrease fluorescence of the collagenase-soluble fraction in the skin of both healthy and diabetic rats. As in diabetic rats, a decreased rate of collagen synthesis and increased collagen fluorescence has also been detected in the skin of aged rats. We hypothesize that dietary xylitol supplementation may protect against these changes during aging. Objective: The purpose of the present study was to investigate whether a long-term dietary supplementation can protect against the decrease in the amounts of newly synthesized collagen, and against the increase in fluorescence in the collagenase-soluble fraction in the skin of aged rats. Methods:Twenty-four male Sprague-Dawley rats were used in the study. After weaning, the rats were divided into 2 groups of 12 animals. The rats in the control group were fed a basal RM1 diet, while the rats in the experimental group were fed the same diet supplemented with 10% xylitol. After 20 months, the rats were killed and pieces of skin from their dorsal areas were excised. The thickness of the samples was measured with a micrometer screw gauge. The collagen contents of rat skin were measured as hydroxyproline, and glycosylation as fluorescent intensity of collagen. Statistical significances of the differences between the groups were determined using the unpaired t test. Results: No general side effects were detected in the rats during the experimental period. The skin of the xylitol-fed rats was a little thicker than that of the control rats. The hydroxyproline content of the acid-soluble fraction was significantly greater in the xylitol group as compared to the controls. However, there were no significant differences in the hydroxyproline content of the collagenase-soluble fraction between the groups. The fluorescence of the collagenase-soluble fraction was significantly smaller in the xylitol-fed aged rats than in the aged rats fed the basal diet. Conclusions: The results of this study indicate that xylitol caused an increase in the amount of newly synthesized collagen and a decrease in collagen fluorescence in the skin of aged rats.

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Section: Discussionsupporting

confidence: 92%

“…Furthermore, dietary xylitol has been shown to increase the amounts of newly synthesized collagen, and to decrease fl uorescence of the collagenasesoluble fraction in the skin of both healthy and diabetic rats [12] .…”

mentioning

confidence: 99%

Effects of a Long-Term Dietary Xylitol Supplementation on Collagen Content and Fluorescence of the Skin in Aged Rats

Mattila

Pelkonen²,

Knuuttila³

2005

Gerontology

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“…From the data of this study, it has been concluded that an intake of xylitol in vivo did not cause problems with lipogenesis because of the suppression of a high-fat induced-visceral fat accumulation, and xylitol intake may be useful to control or prevent obesity, diabetes and other metabolic disorders. Although the effects of 10 and 20% dietary xylilol have been investigated previously [29,30], the objectives of these studies were completely different from the present study. Mattila et al [29] investigated the protective effects of 10 and 20% dietary xylitol on the loss of bone mineral and the weakening of bone biochemical properties, while Knuuttila et al [30] examined the effects of 10% dietary xylitol on collagen content and glycosylation, both in a streptozotocin-induced type 1 diabetes rat model.…”

Section: Introductionmentioning

confidence: 95%

“…Although the effects of 10 and 20% dietary xylilol have been investigated previously [29,30], the objectives of these studies were completely different from the present study. Mattila et al [29] investigated the protective effects of 10 and 20% dietary xylitol on the loss of bone mineral and the weakening of bone biochemical properties, while Knuuttila et al [30] examined the effects of 10% dietary xylitol on collagen content and glycosylation, both in a streptozotocin-induced type 1 diabetes rat model. However, the antidiabetic effect of xylitol either as a sugar substitute or as a supplement has not yet been examined in T2D either in humans or experimental animals.…”

Section: Introductionmentioning

confidence: 95%

Effects of Xylitol on Blood Glucose, Glucose Tolerance, Serum Insulin and Lipid Profile in a Type 2 Diabetes Model of Rats

Islam

Indrajit²

2012

Ann Nutr Metab

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Background/Aims: The present study was conducted to examine the antidiabetic effects of xylitol in a type 2 diabetes rat model. Methods: Six-week-old male Sprague-Dawley rats were randomly divided into 3 groups: normal control (NC), diabetic control (DBC) and xylitol (XYL). Diabetes was induced only in the DBC and XYL animal groups by feeding them a 10% fructose solution for 2 weeks followed by an injection (i.p.) of streptozotocin (40 mg/kg body weight). One week after the streptozotocin injection, the animals with a nonfasting blood glucose level of >300 mg/dl were considered to be diabetic. The XYL group was fed further with a 10% xylitol solution, whereas the NC and DBC groups were supplied with normal drinking water. Results: After 5 weeks of intervention, food and fluid intake, body weight, blood glucose, serum fructosamine and most of the serum lipids were significantly decreased, and serum insulin concentration and glucose tolerance ability was significantly increased in the XYL group compared to the DBC group. Liver weight, liver glycogen and serum triglycerides were not influenced by feeding with xylitol. Conclusion: The data of this study suggest that xylitol can be used not only as a sugar substitute but also as a supplement to antidiabetic food and other food products.

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“…Polyol metabolism requires little or no insulin (20,33). The effects in animal studies include antidiabetic properties such as improved pancreatic islet morphology and blood glucose-lowering effects in heathy and diabetic rats (17,27). In pilot studies of patients with diabetes, daily intake of 36 g of erythritol resulted in improvement of endothelial function and reduced central aortic stiffness (9).…”

mentioning

confidence: 99%

Gut hormone secretion, gastric emptying, and glycemic responses to erythritol and xylitol in lean and obese subjects

Wölnerhanssen

Cajacob

Keller

et al. 2016

American Journal of Physiology-Endocrinology and Metabolism

110

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Effects of dietary xylitol on collagen content and glycosylation in healthy and diabetic rats

Cited by 15 publications

References 0 publications

Effects of a Long-Term Dietary Xylitol Supplementation on Collagen Content and Fluorescence of the Skin in Aged Rats

Effects of a Long-Term Dietary Xylitol Supplementation on Collagen Content and Fluorescence of the Skin in Aged Rats

Effects of Xylitol on Blood Glucose, Glucose Tolerance, Serum Insulin and Lipid Profile in a Type 2 Diabetes Model of Rats

Gut hormone secretion, gastric emptying, and glycemic responses to erythritol and xylitol in lean and obese subjects

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