Effects of dietary weight loss on obstructive sleep apnea: a meta-analysis

Anandam, Anil; Akinnusi, Morohunfolu E.; Kufel, Thomas J.; Porhomayon, Jahan; El-Solh, Ali

doi:10.1007/s11325-012-0677-3

Cited by 72 publications

(39 citation statements)

References 42 publications

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“…Anandam et al [25], in a meta-analysis of studies on dietary weight loss intervention showed a reduction in AHI by 23.1 events/h (95 % CI 8.9–37.3, p = 0.001) corresponding to a 44 % reduction compared with baseline. In another meta-analysis, oral appliances were found to reduce AHI by 12.07 events/h (95 % CI −9.7 to −14.3, p < 0.01), suggesting an improvement of 60.25 % postintervention [37].…”

Section: Discussionmentioning

confidence: 99%

“…We used combinations of the following keywords: “exercise,” “obstructive sleep apnea,” and “sleep-disordered breathing.” The search from PubMed yielded all the studies included in this meta-analysis. To ensure a thorough search of the literature, we hand-searched the reference lists of the included studies and previously published meta-analyses [25, 26] on lifestyle interventions and OSA severity. For inclusion in our meta-analysis, we considered only those studies that reported exercise as a primary component of an intervention and also reported changes in cardiorespiratory fitness.…”

Section: Methodsmentioning

confidence: 99%

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Effects of Exercise Training on Sleep Apnea: A Meta-analysis

Iftikhar

Kline

Youngstedt

2013

Lung

194

137

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Background Several studies have shown a favorable effect of supervised exercise training on obstructive sleep apnea (OSA). This meta-analysis was conducted to analyze the data from these studies on the severity of OSA (primary outcome) in adults. Secondary outcomes of interest included body mass index (BMI), sleep efficiency, daytime sleepiness and cardiorespiratory fitness. Methods Two independent reviewers searched PubMed and Embase (from inception to March 6, 2013) to identify studies on the effects of supervised exercise training in adults with OSA. Pre- and postexercise training data on our primary and secondary outcomes were extracted. Results A total of 5 studies with 6 cohorts that enrolled a total of 129 study participants met the inclusion criteria. The pooled estimate of mean pre- to postintervention (exercise) reduction in AHI was −6.27 events/h (95 % confidence interval [CI] −8.54 to −3.99; p < 0.001). The pooled estimates of mean changes in BMI, sleep efficiency, Epworth sleepiness scale and VO2 peak were −1.37 (95 % CI −2.81 to 0.07; p = 0.06), 5.75 % (95 % CI 2.47–9.03; p = 0.001), −3.3 (95 % CI −5.57 to −1.02; p = 0.004), and 3.93 mL/kg/min (95 % CI 2.44–5.42; p < 0.001), respectively. Conclusions This meta-analysis shows a statistically significant effect of exercise in reducing the severity of sleep apnea in patients with OSA with minimal changes in body weight. Additionally, the significant effects of exercise on cardiorespiratory fitness, daytime sleepiness, and sleep efficiency indicate the potential value of exercise in the management of OSA.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Effects of Exercise Training on Sleep Apnea: A Meta-analysis

Iftikhar

Kline

Youngstedt

2013

Lung

194

137

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“…The findings from behavioral interventions are supported by 2 recent meta-analyses. 159,160 This finding may be particularly true for those with severe OSA. However, well-designed and -executed comparative-effectiveness trials are needed that will further explore the underlying mechanisms between weight loss and SDB and are transparent in the reporting of objectively measured SDB outcomes (ie, changes from baseline to posttreatment follow-up in AHI).…”

Section: Lifestyle Interventions For Sleep Disordersmentioning

confidence: 92%

Sleep Duration and Quality: Impact on Lifestyle Behaviors and Cardiometabolic Health: A Scientific Statement From the American Heart Association

St‐Onge¹,

Grandner²,

Brown³

et al. 2016

Circulation

714

520

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Sleep is increasingly recognized as an important lifestyle contributor to health. However, this has not always been the case, and an increasing number of Americans choose to curtail sleep in favor of other social, leisure, or work-related activities. This has resulted in a decline in average sleep duration over time. Sleep duration, mostly short sleep, and sleep disorders have emerged as being related to adverse cardiometabolic risk, including obesity, hypertension, type 2 diabetes mellitus, and cardiovascular disease. Here, we review the evidence relating sleep duration and sleep disorders to cardiometabolic risk and call for health organizations to include evidence-based sleep recommendations in their guidelines for optimal health.

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“…Evidence suggests that addressing energy intake is more efficacious for weight loss than increasing energy expenditure [30] and that exercise trials that provide dietary advice only are associated with smaller weight losses than those providing a VLED [26, 27]. Although we acknowledged this when designing the study, we feel the severe rate of weight loss, and typical weight regain seen over time is not pragmatic enough for introduction into current healthcare delivery.…”

Section: Discussionmentioning

confidence: 99%

“…Recent meta-analyses have collated evidence on dietary interventions [26] and exercise-based interventions [27] in OSAHS. The former reported a weighted mean reduction in BMI of 4.8 [3.8, 5.9] kg · m −2 and in AHI of 23.1 [8.9, 37.3] events · h −1 .…”

Section: Discussionmentioning

confidence: 99%

Effects of a Pragmatic Lifestyle Intervention for Reducing Body Mass in Obese Adults with Obstructive Sleep Apnoea: A Randomised Controlled Trial

Tew

Copeland

Stout

et al. 2014

BioMed Research International

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This study investigated the effects of a pragmatic lifestyle intervention in obese adults with continuous positive airway pressure-treated obstructive sleep apnoea hypopnoea syndrome (OSAHS). Sixty patients were randomised 1 : 1 to either a 12-week lifestyle intervention or an advice-only control group. The intervention involved supervised exercise sessions, dietary advice, and the promotion of lifestyle behaviour change using cognitive-behavioural techniques. Outcomes were assessed at baseline (week 0), intervention end-point (week 13), and follow-up (week 26). The primary outcome was 13-week change in body mass. Secondary outcomes included anthropometry, blood-borne biomarkers, exercise capacity, and health-related quality of life. At end-point, the intervention group exhibited small reductions in body mass (−1.8 [−3.0, −0.5] kg; P = 0.007) and body fat percentage (−1 [−2, 0]%; P = 0.044) and moderate improvements in C-reactive protein (−1.3 [−2.4, −0.2] mg·L−1; P = 0.028) and exercise capacity (95 [50, 139] m; P < 0.001). At follow-up, changes in body mass (−2.0 [−3.5, −0.5] kg; P = 0.010), body fat percentage (−1 [−2, 0]%; P = 0.033), and C-reactive protein (−1.3 [−2.5, −0.1] mg·L−1; P = 0.037) were maintained and exercise capacity was further improved (132 [90, 175] m; P < 0.001). This trial is registered with ClinicalTrials.gov NCT01546792.

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Effects of dietary weight loss on obstructive sleep apnea: a meta-analysis

Cited by 72 publications

References 42 publications

Effects of Exercise Training on Sleep Apnea: A Meta-analysis

Effects of Exercise Training on Sleep Apnea: A Meta-analysis

Sleep Duration and Quality: Impact on Lifestyle Behaviors and Cardiometabolic Health: A Scientific Statement From the American Heart Association

Effects of a Pragmatic Lifestyle Intervention for Reducing Body Mass in Obese Adults with Obstructive Sleep Apnoea: A Randomised Controlled Trial

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