This study was done to evaluate growth functionality, carcass characteristics and some blood constituents by using different dietary levels of grape seed powder (GSP) 0, 50, 100 and 150 mg/kg live body weight (LBW) daily 28 days on growing APRI rabbits diet. growing APRI female rabbits having live body weight (LBW) of 757.21g and aged 9 weeks were divided into 4 similar groups. The 1st group was fed a control diet without additives (G1), while the 2 nd , 3 rd and 4 th groups (G2, G3 and G4) were fed a control diet supplemented with 50, 100 and 150 mg powder of grape seeds, respectively. All groups were kept at the same environmental conditions (26.5-32.5 o C and 62-75% RH). Results show that total weight, daily weight gain and relative growth rate were significantly higher (p<0.05) (812.78, 29.03 and 72.15 g) in G3 than other groups. Preslaughter weight, carcass weight and edible giblets percentage were significantly (P<0.05) increased in G3 than the other groups. Concentration of plasma total protein, globulin, HDL and LDL were significantly (P< 0.05) higher in G3 than in other groups. Concentration of plasma total lipids, total cholesterol and triglycerides were decreased significantly (P<0.05) as GSP levels were increased.Malondialdehyde (MDA) superoxide dismutase ((SOD), and glutathione peroxidase (GSH-PX) were gradually elevated (P<0.01) by increasing GSP level in the diet.These results suggested that grape seed powder at a level of 100 mg/kg LBW improved growth performance, health status and plasma lipid profile of growing APRI rabbits.