Effects of Dietary Tin on Growth Performance, Hematology, Serum Biochemistry, Antioxidant Status, and Tin Retention in Broilers

Sun, Luo; Zhang, Niya; Zhai, Qin-Hui; Gao, Xin; Li, Chong; Zheng, Qiang; Krumm, Christopher Steven; Qi, Desheng

doi:10.1007/s12011-014-0129-y

Cited by 13 publications

(7 citation statements)

References 36 publications

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“…The time points selected in the present study were based on previous reports [ 57 , 58 ]. Blood samples of adult F1 female rats, as well as the uterus and ovaries of weaned and adult rats, were collected for hormone and histological examinations as previously described [ 59 ].…”

Section: Methodsmentioning

confidence: 99%

Gestational Zearalenone Exposure Causes Reproductive and Developmental Toxicity in Pregnant Rats and Female Offspring

Gao

Sun

Zhang

et al. 2017

Toxins

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Zearalenone (ZEN) is an oestrogenic mycotoxin commonly found in food and feed products and can affect reproduction and development in both humans and animals. This study aimed to determine the toxic effects of ZEN on maternal SD rats and the F1 female offspring. Sixty-four pregnant rats were divided into 4 groups and exposed to feed contaminated with ZEN (0, 5, 10, and 20 mg/kg feed) on gestational days (GDs) 0–21. Compared with the controls, the groups exposed to 10 and 20 mg/kg ZEN showed significantly decreased feed intake and body weight of pregnant rats and/or female offspring. Meanwhile, 20 mg/kg ZEN significantly decreased the birth weight and viability of F1 newborn rats. Moreover, 10 and 20 mg/kg ZEN diets increased follicle-stimulating hormone concentrations but decreased oestradiol in both maternal and F1 adult rats. In the F1 generation, ZEN caused no pathological changes in ovaries and uterus in weaned rats, but significant follicular atresia and a thinning uterine layer were found in F1 female adult rats in the 20 mg/kg ZEN group. These impairments concurred with the inhibited mRNA and protein levels of oestrogen receptor-alpha (Esr1) and 3β-hydroxysteroid dehydrogenase (HSD) in the adult uterus and/or ovaries. Furthermore, 10 and/or 20 mg/kg ZEN exposure significantly reduced Esr1, gonadotropin-releasing hormone receptor (GnRHr), and ATP binding cassette transporters b1 and c1 (ABCb1 and ABCc1) in the placenta and foetal and weaned F1 brains, and also produced a dose-dependent increase in 3β-HSD in the placenta. Additionally, 20 mg/kg ZEN significantly upregulated ABCc5 expression in the placenta and ovaries of weaned rats. These results suggested that prenatal ZEN exposure in rats affected maternal and foetal development and may lead to long-term reproductive impairment in F1 adult females.

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Section: Methodsmentioning

confidence: 99%

Gestational Zearalenone Exposure Causes Reproductive and Developmental Toxicity in Pregnant Rats and Female Offspring

Gao

Sun

Zhang

et al. 2017

Toxins

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“…The CAT assay was measured spectrophotometrically at 520 nm. The formation of MDA was determined as an indicator of lipid peroxidation measuring at 532 nm [24]. Protein concentration was determined using the method by Bradford [25].…”

Section: Biochemical Assaysmentioning

confidence: 99%

Characterization of Selenoprotein M and Its Response to Selenium Deficiency in Chicken Brain

Huang

Ren

Jiang

et al. 2015

Biol Trace Elem Res

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Selenoprotein M (SelM) may function as thiol disulfide oxidoreductase that participates in the formation of disulfide bonds and can be implicated in calcium responses. SelM may have a functional role in catalyzing free radicals and has been associated with Alzheimer's disease (AD). However, studies of SelM in chicken remain very limited. In this study, two groups of day-old broiler chicks (n = 40/group) were fed a corn-soy basal diet (BD, 13 μg Se/kg) and BD supplemented with Se (as sodium selenite) at 0.3 mg/kg. The brain was collected at 14, 21, 28, and 42 days of age. We performed a sequence analysis and predicted the structure and function of SelM. We also investigated the effects of Se deficiency on the expression of Selt, Selw, and Selm and the Se status in the chicken brain. The results show that Se deficiency induced the lower (P < 0.05) Se content, glutathione peroxidase (GPx), and catalase (CAT) activities; increased (P < 0.05) malondialdehyde (MDA) content; and reduced (P < 0.05) the expression of Selm messenger RNA (mRNA) and protein abundance of SelM in the brain. However, there were no significant brain Selt and Selw mRNA levels by dietary Se deficiency in chicks. The different regulations of these three redox (Rdx) protein expressions by Se deficiency represent a novel finding of the present study. Our results demonstrated that SelM may have an important role in protecting against oxidative damage in the brain of chicken, which might shed light on the role of SelM in human neurodegenerative disease. More studies are needed to confirm our conclusion.

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“…A number of studies have focused on the toxic effects of SnCl 2 due to the fact that it has been extensively used for the production of food cans and beverage packaging [2,3]. Exposures to environmental stressors including toxic chemicals that have the potential of modulating the immune system can often be linked to ecologically relevant endpoints, such as reduced resistance to disease [4]. It has immunosuppressive effects in vivo and in vitro [5].…”

Section: Introductionmentioning

confidence: 99%

Annona muricata L. Suppresses Stannous Chloride Effects through Changing Hematological Parameters in Male New Zealand White Rabbits

Ali

Khaled

Saloumah

2021

JOCAMR

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Background: Annona muricata. L has a wide range of therapeutic characteristics and is frequently used in traditional medicine to treat a variety of ailments. Stannous chloride (SnCl2) are widely used in daily life and distributed in many tissues and nutrients. Although over-ingestion of SnCl2, can cause health problems, relatively little attention has been given to the toxic effects of this compound in livestock health and hematological parameters. This study was designed to study protective roles of A. muricata L. against SnCl2 effects through alleviating hematological disturbances in adult male New-Zealand white rabbits. Materials and Methods: Four rabbits per group were assigned to 1 of 4 treatment groups: 0 mg A. muricata and 0 mg SnCl2/kg BW (control); 100 mg of A. muricata /kg BW; 20 mg SnCl2/kg BW; 20 mg SnCl2 plus 100 mg of A. muricata /kg BW. Rabbits were orally administered the respective doses every other day for 10 weeks. Results: The obtained results showed that A. muricata alone caused increase in body weight, relative weight of liver, lung, heart and kidney. It also caused increase hemoglobin (Hb), packed cell volume (PCV) level and number of platelets (PLT) compared to control. However, treatment with A. muricata was caused significant decrease in white blood cell counts (WBCs) and non-significant decrease in red blood cell counts (RBCs), mean cell volume (MCV). Meanwhile, treatment with SnCl2 was lead to adverse effect on the body weight and relative organs weight practically spleen. It was caused significant increase in WBCs, MCV compared to control. The rest of hematological parameters (RBCs, PCV, PLT, Hb and MCHC) were significantly decreased, which indicated to cause anemia. Previous parameters were returned to normal values in group that treatment with A. muricata plus SnCl2. In term of bone marrow smear, all smears are similar in terms of numbers and types of cells. Conclusion: Results of the present study convincingly demonstrated that SnCl2 exposure resulted in varying degree of hematological parameters of rabbits. A. muricata has been promise as nutritional supplements to help prevent disorders involving SnCl2 induced these effects. Thus A. muricata may be helpful to combat SnCl2 associated sufferings in human as well as animal.

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Effects of Dietary Tin on Growth Performance, Hematology, Serum Biochemistry, Antioxidant Status, and Tin Retention in Broilers

Cited by 13 publications

References 36 publications

Gestational Zearalenone Exposure Causes Reproductive and Developmental Toxicity in Pregnant Rats and Female Offspring

Gestational Zearalenone Exposure Causes Reproductive and Developmental Toxicity in Pregnant Rats and Female Offspring

Characterization of Selenoprotein M and Its Response to Selenium Deficiency in Chicken Brain

Annona muricata L. Suppresses Stannous Chloride Effects through Changing Hematological Parameters in Male New Zealand White Rabbits

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