Effects of dietary supplementation with laminarin derived from Laminaria hyperborea and Laminaria digitata on colonic mucin gene expression in pigs

Smith, A.G.; Ryan, M. F.; O’Doherty, John V.; Reilly, P.; Bahar, Bojlul; Sweeney, T.

doi:10.1016/j.livsci.2010.06.064

Cited by 9 publications

(11 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The only significant effect in this study was that dietary supplementation of the soluble laminarin derived from L. digitata at 300 ppm resulted in a significant 1.9 fold increase in expression of MUC2 in the porcine ileum. Similar results have been observed in the porcine colon (Smith et al, 2010). Supplementation with L. hyperborea had no effect on any of the mucins examined.…”

Section: Discussionsupporting

confidence: 87%

“…Complete details are described in Smith et al (2010). Briefly, thirty-five pigs were included in the study and were …”

Section: Animals Management Experimental Design and Dietary Treatmentsmentioning

confidence: 99%

“…Detailed descriptions of tissue preparation, RNA purification and cDNA synthesis are described in Smith et al (2010). Briefly, ileal tissues were sampled 10 cm from the ielocaecal valve.…”

Section: Sample Preparation and Quantitative Real-time Pcr (Qpcr) Andmentioning

confidence: 99%

“…The geometric mean of two previously validated endogenous controls GAPDH and PPIA, were used to normalise the target mucin genes (Vandesompele et al, 2002). Statistical methodology is described in Smith et al (2010).…”

Section: Sample Preparation and Quantitative Real-time Pcr (Qpcr) Andmentioning

confidence: 99%

See 3 more Smart Citations

Effects of nutrient supplementation with laminarin derived from Laminaria hyperborea and Laminaria digitata on mucin gene expression in the porcine ileum

et al. 2010

Self Cite

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 87%

“…Complete details are described in Smith et al (2010). Briefly, thirty-five pigs were included in the study and were …”

Section: Animals Management Experimental Design and Dietary Treatmentsmentioning

confidence: 99%

“…Detailed descriptions of tissue preparation, RNA purification and cDNA synthesis are described in Smith et al (2010). Briefly, ileal tissues were sampled 10 cm from the ielocaecal valve.…”

Section: Sample Preparation and Quantitative Real-time Pcr (Qpcr) Andmentioning

confidence: 99%

Section: Sample Preparation and Quantitative Real-time Pcr (Qpcr) Andmentioning

confidence: 99%

See 2 more Smart Citations

Effects of nutrient supplementation with laminarin derived from Laminaria hyperborea and Laminaria digitata on mucin gene expression in the porcine ileum

et al. 2010

Self Cite

View full text Add to dashboard Cite

“…Total RNA extraction for all ileal and colonic tissue (25 mg), cDNA synthesis and quantitative real-time PCR (qPCR) was performed according to the method described by Smith et al (2010). All primers were designed using Primer Express™ using sequence data (Reilly et al, 2008) and were synthesised by MWG Biotech (Milton Keynes, UK).…”

Section: Rna Extraction and Rt-pcr Analysismentioning

confidence: 99%

The effects of supplementing the diet of the sow with seaweed extracts and fish oil on aspects of gastrointestinal health and performance of the weaned piglet

Leonard¹,

Sweeney²,

Pierce³

et al. 2010

Livestock Science

Self Cite

View full text Add to dashboard Cite

Polysaccharides from brown seaweed: Physicochemical properties, absorption in the intestine, and beneficial effects on intestinal barrier

et al. 2023

View full text Add to dashboard Cite

The intestinal barrier is critical in maintaining gut homeostasis and host health. The intestinal barrier dysfunction contributes to intestinal and systemic diseases like inflammatory bowel disease, colorectal cancer, and metabolic syndromes. This review summarizes the physicochemical properties of three main kinds of brown seaweed polysaccharides (BSP), laminarin, fucoidan, and alginate, along with their absorption and metabolism in the intestine and their effects on the intestinal barrier. The physicochemical properties of BSP were closely related to their beneficial effects on intestinal health. BSP were not digested directly in the upper gastrointestinal tract but could be utilized through fermentation by the gut microbiota. BSP kept the integrity of intestinal epithelium by ameliorating intestinal oxidative stress through the nuclear factor erythroid 2‐related factor 2 signaling pathway. They also reduced tight junction dysfunction and intestinal permeability and increased the expression of mucins. Moreover, BSP regulated the composition and abundance of gut microbiota and promoted the production of beneficial metabolites such as short‐chain fatty acids. This review will help to understand the gut health‐promoting functions of the natural compounds derived from brown seaweed and offer a new perspective on intestinal disease prevention and therapy with high effectiveness and safety.

show abstract

Effects of dietary supplementation with laminarin derived from Laminaria hyperborea and Laminaria digitata on colonic mucin gene expression in pigs

Cited by 9 publications

References 8 publications

Effects of nutrient supplementation with laminarin derived from Laminaria hyperborea and Laminaria digitata on mucin gene expression in the porcine ileum

Effects of nutrient supplementation with laminarin derived from Laminaria hyperborea and Laminaria digitata on mucin gene expression in the porcine ileum

The effects of supplementing the diet of the sow with seaweed extracts and fish oil on aspects of gastrointestinal health and performance of the weaned piglet

Polysaccharides from brown seaweed: Physicochemical properties, absorption in the intestine, and beneficial effects on intestinal barrier

Contact Info

Product

Resources

About