Effects of dietary supplementation of a zinc oxide product encapsulated with lipid on growth performance, intestinal morphology, and digestive enzyme activities in weanling pigs

Park, B.C.; Jung, Dae Yun; Kang, Sun-Young; Ko, Young-Hyun; Ha, Duck-Min; Kwon, C. H.; Park, M.J.; Han, Jeong Hee; Jang, In-Surk; Lee, C.Y.

doi:10.1016/j.anifeedsci.2014.11.016

Cited by 22 publications

(36 citation statements)

References 19 publications

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“…Treatment C (commercial peat without ZnO-additives) and treatment D (controls) resulted in significantly higher fecal scores than treatment A (2819 mg/L uncoated ZnO) at Farms 1 to 3. These findings are consistent with a previously published study showing that 14 days of post weaning ZnO-inclusion in feed affected fecal consistency, and that 3125 mg/kg of uncoated ZnO led to firmer fecal consistency than the inclusion of 139 mg/kg feed of a lipid encapsulated ZnO source called Shield Zn [75]. In the present study, basal diets at Farms 1–3 contained between 16% and 19.6% crude protein.…”

Section: Discussionsupporting

confidence: 93%

Zinc oxide enriched peat influence Escherichia coli infection related diarrhea, growth rates, serum and tissue zinc levels in Norwegian piglets around weaning: five case herd trials

et al. 2017

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BackgroundZinc oxide (ZnO), commonly used to control post-weaning diarrhea in piglets, has been highlighted as of potential concern from an environmental perspective. The aim of this field trial was to examine effects of different sources and levels of ZnO added to peat on average daily weight gain (ADG), fecal score in pens and serum and tissue zinc (Zn) levels around time of weaning in order to reduce the environmental impact without loss of the beneficial effect of ZnO on intestinal health and growth. Five case herds with enterotoxic colibacillosis challenges were included. The piglets entered the study aged three or five weeks. All piglets received a commercial diet containing <150 mg Zn/ per kg of complete feed. Four treatment groups received commercial peat added A: uncoated ZnO, B: lipid microencapsulated ZnO, C: solely commercial peat or D: no peat (Farms 2 and 3).ResultsAt Farms 1, 2 and 3, a significant effect of treatment was identified for fecal score (P < 0.05). Treatment A led to lower fecal scores compared to treatments C (P < 0.05) and D (P < 0.01). At Farms 2 and 3, there was a significant difference in individual average daily weight gain (iADG) between treatment A and D (P < 0.05). The iADG of piglets receiving treatment B did not differ significantly from treatment A.ConclusionsIn 2016, The European Medicines Agency’s Committee on Veterinary Medicinal Products concluded that the benefits of ZnO for the prevention of diarrhea in pigs do not outweigh the risks to the environment. Effective alternative measures to reduce the accumulation of Zn in the environment have not been identified. Our results imply that peat added low concentration of both coated and uncoated ZnO influences the gut health of weaned piglets reflected by enhanced weight gain and reduced occurrence of diarrhea. This preventive approach certainly represents a favourable alternative in the “One Health” perspective. It will also contribute to reduced antibiotic use in pig farming while diminishing the environmental consequences caused by ZnO.

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Section: Discussionsupporting

confidence: 93%

Zinc oxide enriched peat influence Escherichia coli infection related diarrhea, growth rates, serum and tissue zinc levels in Norwegian piglets around weaning: five case herd trials

et al. 2017

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“…This may indicate that zinc plays a crucial role in protein synthesis. Its role as a co-factor for more than 80 metalloenzymes necessary for protein synthesis has been reported (Park et al, 2015;Byun et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Effect of zinc oxide on liveweight, reproductive organ dimensions and spermatozoa production of Archachatina marginata during dry season

Abiona

Olaoye

Abioja

et al. 2018

Agricultura Tropica Et Subtropica

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Demand for Giant African Land Snail in Nigeria is so high such that it is very difficult to meet up with the supply as a protein source. However, during dry season, production at intensive level is often challenged with decline in growth and reproduction despite interventions to boost production. This study therefore evaluates the effect of zinc oxide on liveweight, reproductive organ dimensions and spermatozoa production of Giant African Land Snail (Archachatina marginata) during dry season. Thirty-two (32) snails with an average weight of 100 – 180 g were used for this experiment. The snails were allotted to four different feeding treatments which included concentrate diet only, concentrate +10 mg/kg of zinc oxide, concentrate +15 mg/kg of zinc oxide and concentrate +20 mg/kg of zinc oxide, respectively. Each treatment contained eight replicates. After nine weeks, five snails were selected from each treatment and dissected. Variables monitored were: weekly weight gain, shell circumference, shell length and shell diameter. Other reproductive data collected after dissections were: organ weight, reproductive tract weight, albumen weight, ovo-testis weight, gonado-somatic index (GSI) and spermatozoa concentration. The result showed that dietary zinc oxide significantly (P < 0.001) influenced feed intake, shell parameters, organ weight ovo-testis weight, albumen weight, gonado-somatic index, reproductive tract weight and spermatozoa concentration. Snailsfed zinc oxide supplemented diet had better shell measurements, organ weight, ovo-testis weight, albumen weight, gonadosomatic index and reproductive tract weight. Considering spermatozoa concentration, 10 mg/kg of zinc oxide inclusion into concentrate diet gave the highest concentration. The results of the present study showed that dietary zinc oxide positively influenced feed intake, shell measurements, organ weight, ovo-testis and albumen weight. Similarly, gonado-somatic index and spermatozoa production were also positively influenced. Therefore, 10 mg/kg inclusion of zinc oxide is recommended for better reproductive tract development, and spermatozoa production at the desirable economic level during the dry season production of Archachatina marginata.

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“…All animals were killed by electric stunning at termination of the feeding trial, after which the entire gastrointestinal (GI) tract was removed as described previously (Lee et al., ). Cross‐sectional segments of the duodenum, jejunum, ileum, colon and caecum were taken for determination of relative counts of E. coli in these tissues as well as for histomorphological examination of their mucosae as described (Kwon et al., ; Park et al., ). The pH of the digesta along the GI tract was measured using the litmus paper (Thomas Scientific, Swedesboro, NJ, USA).…”

Section: Methodsmentioning

confidence: 99%

“…The intestinal tissue was fixed, embedded, sliced, mounted on the glass slide and stained as described previously (Lee et al, 2011;Kwon et al, 2014;Park et al, 2015). The goblet cell density, villous height (VH) and crypt depth (CD) were determined microscopically using the Diagnostic Insight visual analysis program (Olympus, Tokyo, Japan) also as described (Lee et al, 2011;Kwon et al, 2014).…”

Section: Histomorphological Examinationmentioning

confidence: 99%

Effects of dietary supplementation of bacteriophages against enterotoxigenic Escherichia coli (ETEC) K88 on clinical symptoms of post‐weaning pigs challenged with the ETEC pathogen

Lee

Kim

Park

et al. 2016

Animal Physiology Nutrition

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The present study was performed to investigate the effects of dietary supplementation of bacteriophages (phages) against enterotoxigenic Escherichia coli (ETEC) K88 as a therapy against the ETEC infection in post-weaning pigs. Two groups of post-weaning pigs aged 35 days, eight animals per group, were challenged with 3.0 × 10 colony forming units of ETEC K88, a third group given the vehicle. The unchallenged group and one challenged group were fed a basal nursery diet for 14 days while the remaining challenged group was fed the basal diet supplemented with 1.0 × 10 plaque forming units of the phage per kg. Average daily gain (ADG), goblet cell density and villous height:crypt depth (VH:CD) ratio in the intestine were less in the challenged group than in the unchallenged group within the animals fed the basal diet (p < 0.05); the reverse was true for rectal temperature, faecal consistency score (FCS), E. coli adhesion score (EAS) in the intestine, serum interleukin-8 (IL-8) and tumour necrosis factor-α (TNF-α) concentrations and digesta pH in the stomach, caecum and colon. The ETEC infection symptom within the challenged animals was alleviated by the dietary phage supplementation (p < 0.05) in ADG, FCS, EAS in the jejunum, serum TNF-α concentration, digesta pH in the colon, goblet cell density in the ileum and colon and VH:CD ratio in the ileum. Moreover, the infection symptom tended to be alleviated (p < 0.10) by the phage supplementation in rectal temperature, EAS in the ileum and caecum, and VH:CD ratio in the duodenum and jejunum. However, EAS in the colon, digesta pH in the stomach and caecum, and goblet cell density in the jejunum did not change due to the dietary phage. Overall, results indicate that the phage therapy is effective for alleviation of acute ETEC K88 infection in post-weaning pigs.

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Effects of dietary supplementation of a zinc oxide product encapsulated with lipid on growth performance, intestinal morphology, and digestive enzyme activities in weanling pigs

Cited by 22 publications

References 19 publications

Zinc oxide enriched peat influence Escherichia coli infection related diarrhea, growth rates, serum and tissue zinc levels in Norwegian piglets around weaning: five case herd trials

Zinc oxide enriched peat influence Escherichia coli infection related diarrhea, growth rates, serum and tissue zinc levels in Norwegian piglets around weaning: five case herd trials

Effect of zinc oxide on liveweight, reproductive organ dimensions and spermatozoa production of Archachatina marginata during dry season

Effects of dietary supplementation of bacteriophages against enterotoxigenic Escherichia coli (ETEC) K88 on clinical symptoms of post‐weaning pigs challenged with the ETEC pathogen

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