Effects of dietary supplementation of pioglitazone on metabolism, milk yield, and reproductive performance in transition dairy cows

Yousefi, Ali Reza; Kohram, Hamid; Shahneh, Ahmad Zare; Zamiri, Mohammad Javad; Fouladi-Nashta, Ali A.

doi:10.1016/j.theriogenology.2016.01.015

Cited by 11 publications

(25 citation statements)

References 54 publications

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“…We did not observe any significant effect of TZD on insulin sensitivity indexes, with only numerically greater QUICKI compared to control animals prior to IMI. Lack of effect on insulin sensitivity indexes in our study is in accordance with data in dairy cows from Schoenberg and Overton [73], where the TZD was used before birth, and Yousefi and collaborators [74], where pioglitazone, another thiazolidinedione and a well-established synthetic PPAR γ ligand, was used during the entire transition period.…”

Section: Discussionsupporting

confidence: 90%

2,4-Thiazolidinedione Treatment Improves the Innate Immune Response in Dairy Goats with Induced Subclinical Mastitis

et al. 2017

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Mastitis is a major disease in dairy cows resulting in significant economic losses. In vitro works suggest that ruminants peroxisome proliferator-activated receptor gamma (PPARγ) can aid in improving the response to mastitis and can control milk fat synthesis. The objectives of the present experiment were to test if treatment with the putative PPARγ agonist 2,4-thiazolidinedione (TZD) improves (1) the response to subclinical mastitis and (2) milk fat production. Lactating goats received daily injections of 8 mg/kg BW of TZD or saline for 3 weeks. After one week of TZD injection, half of the goats in each group received intramammary infusion of Strep. uberis or saline in both halves for a total of 4 groups (n = 6/group). TZD treatment did not affect milk fat but had positive effect on milk somatic cells count, blood nonesterified fatty acids, inflammatory markers, and liver function. TZD significantly increased myeloperoxidase but did not affect leukocytes phagocytosis or insulin. TZD increased adipocytes size and had minor effect on expression of PPARγ target genes in mammary epithelial cells but not in adipose tissue. Overall, TZD ameliorated the response to intramammary infection but the effect on milk fat synthesis and expression of related transcripts was less than expected.

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Section: Discussionsupporting

confidence: 90%

2,4-Thiazolidinedione Treatment Improves the Innate Immune Response in Dairy Goats with Induced Subclinical Mastitis

et al. 2017

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“…In line with Smith et al (2007) and Yousefi et al (2016), results of the present study showed that dietary PGT and WM during the first 21 d of postpartum had no effect on milk yield and milk composition. It is well documented that there is a relationship between the BCS at calving and BCS loss postpartum.…”

Section: Discussionsupporting

confidence: 91%

“…This result may be ascribed to the short duration of the dietary supplementation. Yousefi et al (2016) who fed 6 mg PGT for a 35 d period reported higher plasma IGF-1 in transition dairy cows.…”

Section: Discussionmentioning

confidence: 97%

“…In addition to NEFA, BHBA is another metabolites which is related to energy balance and liver function in dairy cows (Ospina et al 2010) and lower plasma BHBA could be attributed the lower NEFA availability in liver (Allen et al 2005; Yousefi et al 2016). There are some reports for lower plasma BHBA (Yousefi et al 2016) or even higher plasma BHBA (Smith et al 2009) after administration PGT or TZD in transition dairy cows. Our results showed that feeding PGT or WM had no effect on plasma BHBA that was in agreement with Ghoreishi (2012).…”

Section: Discussionmentioning

confidence: 99%

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Effects of dietary supplementation of pioglitazone or walnut meal on metabolic profiles and oxidative status in dairy cows with high pre-calving BCS

Gheise

Ahmad

Celi³

et al. 2018

Journal of Dairy Research

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This research paper addresses the hypothesis that dietary pioglitazone (PGT), as synthetic and specific ligand for PPAR-γ or walnut meal (WM) as a natural ligand for PPAR-γ, affect plasma metabolites and reduce the oxidative status in high body condition score (BCS) dairy cows (≥4 BCS). Total of 36 multiparous Holstein cows were randomly assigned to one of the dietary treatments: 1- Control (basal diet; CTR), 2- Walnut meal (9·45% walnut meal of DMI; WM), and 3- Pioglitazone (6 mg/kg BW; PGT). The experimental diets were fed from parturition time to 21 d postpartum. Results showed that the PGT supplementation increased dry matter intake (DMI) (22·95 kg/d) compared to the CTR (21·45 kg/d) and WM (21·78 kg/d) groups. Results showed that milk yield and milk composition were not affected by the experimental diets. Body condition score losses tended to be higher in the CTR group compared to the PGT and WM cows. The PGT group had higher plasma insulin compared to the CTR group (11·84 vs. 10·68 mIU/l), and WM cows had intermediate plasma insulin. The PGT cows had lower plasma non esterified fatty acid (NEFA) and tended to have lower β-hydroxy butyric acid (BHBA) than the CTR group. Feeding pioglitazone decreased plasma malondialdehyde (MDA) and increased plasma total antioxidant capacity (TAC) and superoxide dismutase (SOD) compared to the CTR and WM groups. It was concluded that dietary pioglitazone had positive effects on DMI, BCS change, blood metabolites and oxidative status in fresh dairy cows with high pre-calving BCS. The anti-oxidant effects of walnut meal were not supported by the present data.

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“…The most striking finding of the present study was the effect of PBLC+B on BW. Because of a negative energy balance, high-yielding dairy cows typically lose between 40 and 70 kg BW at one to two months after calving [ 60 – 62 ]. A weight loss of ~70 kg was also observed in the CON and MON groups in Phase 3 of the present study.…”

Section: Discussionmentioning

confidence: 99%

Effects of a combination of plant bioactive lipid compounds and biotin compared with monensin on body condition, energy metabolism and milk performance in transition dairy cows

et al. 2018

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The aim of this study was to test whether a combination of plant bioactive lipid compounds (also termed ‘essential oils’) and biotin (PBLC+B) could decrease the mobilization of body reserves and ketosis incidence in postpartum dairy cows. We compared non-supplemented control (CON) cows with cows receiving monensin (MON) as a controlled-release capsule at d -21, and with cows receiving PBLC+B from day (d) -21 before calving until calving (Phase 1) and further until d 37 after calving (Phase 2), followed by PBLC+B discontinuation from d 38 to d 58 (Phase 3). The PBLC+B cows had higher body weight and higher back fat thickness than CON cows and lesser body weight change than MON and CON cows in Phase 3. Body condition score was not different among groups. Milk protein concentration tended to be higher on the first herd test day in PBLC+B vs. CON cows. Milk fat concentration tended to be highest in PBLC+B cows throughout Phases 2 and 3, with significantly higher values in PBLC+B vs. MON cows on the second herd test day. Yields of energy-corrected milk were higher in PBLC+B vs. CON and MON cows in Phase 2 and higher in PBLC+B and MON cows vs. CON cows in Phase 3. The incidence of subclinical ketosis was 83%, 61% and 50% in CON, PBLC+B and MON cows, respectively, with lower mean β-hydroxybutyrate values in MON than in PBLC+B cows in Phase 1 prepartum. The serum triglyceride concentration was higher in PBLC+B vs. CON cows on d 37. No differences were observed in serum glucose, urea, non-esterified fatty acids, cholesterol and bilirubin concentrations. Aspartate transaminase and γ-glutamyltranspeptidase but not glutamate dehydrogenase activities tended to be highest in MON and lowest in PBLC+B in Phase 2. We conclude that PBLC+B prevent body weight loss after parturition and are associated with similar ketosis incidence and partly higher yields of energy-corrected milk compared to MON supplementation of dairy cows.

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Effects of dietary supplementation of pioglitazone on metabolism, milk yield, and reproductive performance in transition dairy cows

Cited by 11 publications

References 54 publications

2,4-Thiazolidinedione Treatment Improves the Innate Immune Response in Dairy Goats with Induced Subclinical Mastitis

2,4-Thiazolidinedione Treatment Improves the Innate Immune Response in Dairy Goats with Induced Subclinical Mastitis

Effects of dietary supplementation of pioglitazone or walnut meal on metabolic profiles and oxidative status in dairy cows with high pre-calving BCS

Effects of a combination of plant bioactive lipid compounds and biotin compared with monensin on body condition, energy metabolism and milk performance in transition dairy cows

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