Effects of dietary supplementation of Clostridium butyricum H129 on growth performance and intestinal health of turbot, Scophthalmus maximus

Bi, Xiujuan; Lv, Chengjie; Wang, Mengmei; Chen, Yuying; Lv, Xiaojing; Hua, Shaomeng; Zhang, Xiaoli; Yang, Dinglong; Zhao, Jianmin; Mu, Changkao

doi:10.1016/j.aqrep.2023.101544

Cited by 2 publications

(1 citation statement)

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“…When added to the diet of hybrid groupers, it was found to improve growth performance, antioxidant capacity, and increase the abundance and diversity of bene cial gut bacteria (Yang et al 2023). CB can also enhance the intestinal mucosal barrier of turbot, reduce intestinal in ammatory factors, and thus improve gut health (Bi et al 2023). Therefore, CB has various functions such as promoting growth, enhancing immunity, improving antioxidant capacity, and modifying the gut microbiota.Currently, the primary research is centered around investigating the effects of CB on the intestinal system.…”

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confidence: 99%

Analyzing the Influence of Clostridium butyricum on Liver Health in Spotted Sea Bass (Lateolabrax maculatus) via Transcriptomics and Metabolomics

Kong,

Ma,

Lin

et al. 2023

Preprint

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Clostridium butyricum (CB) has received much attention as a probiotic; however, few studies have focused on its effects on liver health. Here, we studied the influence of CB on the liver health of spotted sea bass through transcriptomic and metabolomic studies and preliminarily explored its molecular mechanisms. This study showed that CB significantly reduced hepatic aspartate aminotransferase (AST) activity and increased alkaline phosphatase (AKP) and acid phosphatase (ACP) activity (P < 0.05). CB has demonstrated significant effects in strengthening liver immunity and can increase hepatic amylase and trypsin activities and promote hepatic catabolism of carbohydrates and amino acids. Integration of the liver Transcriptomics and metabolomics showed altered transcript levels of mainly gluconeogenic, lipogenic, and amino acid metabolic pathways. It regulated the abundance of metabolic biomarkers such as arachidonate, crotonyl-CoA, and D-glucose 1-phosphate. Our findings support that CB can reduce liver damage in spotted sea bass, enhance liver immunity, and improve liver metabolism.

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confidence: 99%