Effects of Dietary Selenium Supplementation on Seminiferous Tubules and SelW, GPx4, LHCGR, and ACE Expression in Chicken Testis

Khalid, Ahmed; Khudhair, Nagam; Huang, He; Zheng, Ping; Tian, Yange; Zhang, Guixue

doi:10.1007/s12011-016-0646-y

Cited by 22 publications

(7 citation statements)

References 32 publications

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“…The GSH-Px is involved in sperm maturation and has a very high activity in the sperm tail structure, which confirms a beneficial role for Se in male fertility ( Khalid et al, 2016 ). These mechanisms may explain the better semen quality in Se-supplemented roosters.…”

Section: Discussionmentioning

confidence: 65%

“…In this line, results of this study showed that histological parameters of testis including seminiferous tubule diameter and seminiferous epithelium thickness were improved in SeY0.45 group and other organic Se sources. There is a relationship between increased dietary Se supplementation and enhanced seminiferous tubule diameter and seminiferous epithelium thickness in chicken ( Khalid et al, 2016 ). Supplementation of vitamin E and Se has shown to increase the diameter, thickness, and height of the germinal epithelium of the seminiferous tubules in rat and chicken ( Mehranjani et al, 2009 ; Khalid et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

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Effects of dietary supplementation of different sources and levels of selenium on the semen quality and reproductive performance in aged broiler breeder roosters

et al. 2022

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Effects of dietary supplementation of different sources and levels of selenium on the semen quality and reproductive performance in aged broiler breeder roosters

et al. 2022

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“…The status of testicle structure and function plays a role in determining the sperm quality, and histopathological alterations in chick testis in the Low-Se group could easily lead to reproductive system dysfunction. Khalid et al (2016) have investigated the effects of dietary Se supplementation on the development of chicken testis, and the results were showed that sufficient Se in the diet could improve the quantity of germ cells and the survivability of supporting cells in seminiferous tubules. These results indicated that Se deficiency could damage testis tissue of chicks, and supplement with an appropriate amount of Se could promote the growth and development of the body and testes to a certain extent.…”

Section: Discussionmentioning

confidence: 99%

Effects of selenium deficiency on testis development and autophagy in chicks

Zhang

2020

Italian Journal of Animal Science

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To investigate the effects of Selenium (Se) deficiency on testis development and autophagy in chicks. 20 1-day old cocks were randomly divided into two groups, named the control check (CK) group [a basic diet (containing 0.333 mg Se/kg) was fed] and the Se-deficiency (Low Se) group [a selenium deficiency diet (containing 0.033 mg Se/kg) was supplied]. After 30 days, the body and testicle weights of the chicks were measured, and the organ coefficient was calculated. While haematoxylin-eosin staining, enzyme-linked immunosorbent assay, colorimetric method was used to assess the histopathological changes of testis, the changes of sex hormone levels, and antioxidant enzyme activities in two groups of chicks, respectively, the mRNA and protein expression of autophagy-related factors in the testes was determined by using quantitative PCR and western blotting. We found that Se deficiency resulted in a significant decrease in body and testicle weights of the chicks, a reduction in organ coefficients, and damaged testis tissue. The levels of sex hormone testosterone, oestradiol, the activities of serum antioxidant enzymes T-AOC, GSH-ST and GSH-PX in the Low-Se group were significantly lower than those in the CK group. Furthermore, the level of autophagy was significantly increased in the Low-Se group compared with the CK counterpart. The mRNA levels of Beclin1, Dynein, ATG-4B, ATG5, LC3-A and LC3-B genes in the Low-Se group were significantly higher than those in the CK group, while the protein expression of ATG5 and LC3-B was significantly increased in the Low-Se group compared with the CK counterpart. These data indicates dietary selenium-deprived chicks exhibit poor testicular development, impaired sex hormone synthesis, reduced antioxidant enzyme activity, and increased mRNA and protein expression of autophagy-related factors. HIGHLIGHTS Se-deprived chicks display poor testicular development, impaired sex hormone synthesis, reduced activity of antioxidant enzymes, and increased mRNA and protein levels of autophagy-related factors.

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“…Khalid et al. (2016) suggested that dietary supplemented Se maintains the normal development of the seminiferous tubules. Khalaf et al.…”

Section: Introductionmentioning

confidence: 99%

Selenium attenuates bisphenol A incurred damage and apoptosis in mice testes by regulating mitogen‐activated protein kinase signalling

et al. 2021

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Being a vital micronutrient, along with a trace element, selenium (Se) protects the cells from oxidative stress (OS) in the form of selenoproteins. Bisphenol A (BPA) is a xeno‐oestrogenic compound that adversely affects the spermatogenesis process by inducing oxidative stress, which ultimately leads to male infertility. Therefore, it is hypothesised that Se could protect against BPA‐induced OS, and further germ cell death by modifying mitogen‐activated protein kinase (MAPK) signalling. Male Balb/c mice were divided into four groups: Group I (C) (0.2 ppm Se), Group II (Se) (0.5 ppm Se), Group III (BPA) (0.2 ppm Se, and BPA = 1 mg/kg orally) and Group IV (Se + BPA) (0.5 ppm Se, and BPA = 1 mg/kg bodyweight orally). Results indicated that BPA‐treated animals demonstrated a marked decrease in antioxidant enzyme activities (superoxide dismutase, catalase, redox ratio), a marked elevation in the expressions of stress‐activated kinases (c‐Jun NH2‐terminal kinase (JNK), extracellular signal‐regulated kinase (ERK) and p38) and the expressions of pro‐apoptotic markers (caspase‐9, caspase‐8 and caspase‐3). However, Se supplementation considerably restored the antioxidant enzyme activities and lowered the expressions of stress‐activated kinases, which further down‐regulated the apoptosis. Thus, Se supplementation demonstrated to be effective against BPA provoked testicular damage.

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Effects of Dietary Selenium Supplementation on Seminiferous Tubules and SelW, GPx4, LHCGR, and ACE Expression in Chicken Testis

Cited by 22 publications

References 32 publications

Effects of dietary supplementation of different sources and levels of selenium on the semen quality and reproductive performance in aged broiler breeder roosters

Effects of dietary supplementation of different sources and levels of selenium on the semen quality and reproductive performance in aged broiler breeder roosters

Effects of selenium deficiency on testis development and autophagy in chicks

Selenium attenuates bisphenol A incurred damage and apoptosis in mice testes by regulating mitogen‐activated protein kinase signalling

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