Effects of dietary protein deficiency on the conjugation of foreign compounds in rat liver

Wood, G. C.; Woodcock, Barry G.

doi:10.1111/j.2042-7158.1970.tb08581.x

Cited by 24 publications

(15 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results were found with respect to cytochrome P450 activities (Marshall and McLean, 1969). Wood and Woodcock (1970) found that removing protein from the diet significantly increased the activity of UDP-GT in rats. In the parsnip worm, Depressaria pastinacella, a 75% decrease in dietary protein, produced a 60% decrease in their growth while the level of xanthotoxin detoxification was maintained.…”

Section: R-nf Effects On Blood Parameters and Enzyme Activitiessupporting

confidence: 78%

“…Very little information is available on the effects of dietary composition on fish detoxification abilities, however studies on the red drum, Sciaenops ocellatus, have demonstrated that by increasing dietary lipid content by 21%, hepatic EROD activity increased three-fold, suggesting that the high dietary lipid content augmented the synthesis of the enzyme (Craig et al, 1999). More studies have been completed with mammals demonstrating that the amount of protein (Marshall and McLean, 1969;Wood and Woodcock, 1970;Paine and McLean, 1973;Sachan, 1975) and the type and concentration of lipid (Ammouche et al, 1993, Shavila et al, 1994 in a diet can differentially affect basal mixed-function oxidase systems.…”

Section: R-nf Effects On Blood Parameters and Enzyme Activitiesmentioning

confidence: 99%

See 1 more Smart Citation

The effects of diet composition and ration on biotransformation enzymes and stress parameters in rainbow trout, Oncorhynchus mykiss

Morrow

Higgs

Kennedy

2004

Comparative Biochemistry and Physiology Part C: Toxicology &

View full text Add to dashboard Cite

Degree:Master of ~nvironmentai ToxicologyTitle of Project:The effects of diet composition and ration on biotransformation enzymes and stress parameters in rainbow trout, Oncorhynchus mykiss. PARTIAL COPYRIGHT LICENCEI hereby grant to Simon Fraser University the right to lend my thesis, project or extended essay (the title of which is shown below) to users of the Simon Fraser University Library, and to make partial or single copies only for such users or in response to a request from the library of any other university, or other educational institution, on its own behalf or for one of its users. I further agree that permission for multiple copying of this work for scholarly purposes may be granted by me or the Dean of Graduate Studies. It is understood that copying or publication of this work for financial gain shall not be allowed without my written permission. Title of ThesislProjecff Extended EssayThe effects of diet composition and ration on biotransforrnation enzymres and stress parameters in rainbow trout, Oncorhynchus mykiss.Michelle Dayna Morrow (name) ABSTRACTNutritional quality and quantity play significant roles in the amount of energy an animal assimilates and in the distribution of that energy. Furthermore, energy is allocated in a hierarchical fashion beginning with basal metabolism and then successively to other physiological processes depending on other energetic requirements of the animal. To date, little information exists on the effects of diet and ration on the stress response and detoxification system in fish. Therefore, the purpose of this study was to measure the effects of dietary composition and ration on the biotransformation and stress response systems in juvenile rainbow trout.Juvenile rainbow trout (Oncorhynchus mykiss) were fed one of three isoenergetic diets varying in protein (35 to 55%) and lipid content (8 to 18%), at full satiation or partial ration for 6 weeks in order to investigate the effects of diet on baseline stress parameters and biotransformation enzyme activity. Growth was highest in fish fed low protein, high lipid diets at both ration levels and was highest overall in fish fed to satiation. Stress indicators, including plasma lactate, glucose and cortisol concentrations were not significantly affected by dietary treatment or ration. Basal biotransformation enzyme activity, including glutathione S-transferase (GST) and ethoxyresorufin 0-deethylase (EROD) activity, were also unaffected by dietary treatment. Fish exposed to the biotransformation enzyme inducer 13-napthoflavone did not exhibit an alteration in stress indicators or GST activity; however, EROD activity was increased (87 to 210-fold) in fish receiving all diets and rations demonstrating the importance of this system even under limited energy intake.The results of the present study indicate that, unlike mammals, fish may be more recalcitrant to different levels of ingestion (above maintenance ration) of isoenergetic ACKNOWLEDGEMENTS

show abstract

Section: R-nf Effects On Blood Parameters and Enzyme Activitiessupporting

confidence: 78%

Section: R-nf Effects On Blood Parameters and Enzyme Activitiesmentioning

confidence: 99%

The effects of diet composition and ration on biotransformation enzymes and stress parameters in rainbow trout, Oncorhynchus mykiss

Morrow

Higgs

Kennedy

2004

Comparative Biochemistry and Physiology Part C: Toxicology &

View full text Add to dashboard Cite

show abstract

“…In addition, fasting for 3 days in adult males produced a decrease in UDPG dehydrogenase activity, but no change in PNP conjugation (31). On the other hand, acute starvation of weanling male rats was shown to increase glucuronyl-transferase activity while decreasing sulfotransferase activity (37). Further support for the concept that growing animals react differently when subjected to nutritional stress was gained when suckling rats were raised in litters of 18 instead of 10 (5).…”

Section: Discussionsupporting

confidence: 54%

“…Undernutrition during the suckling period results in a variable pattern where the in vitro metabolism of some substrates (aminopyrine) is increased whereas it is decreased for others (neoprontosil) (5). Weanling rats kept on a low protein diet for 7 days have an increased glucuronyltransferase activity as mea sured by p-nitrophenol (PNP) conjugation in vitro and a decreased sulfotransferase activity with dehydroepiandrosterone as sulfate acceptor substrate (37). It was demonstrated that during the same stage of development a hepatic oxidizing enzyme, biphenyl 4-hydroxylase was susceptible to deficiency of total calories and a reductase enzyme (p-nitrobenzoate as substrate) was dependent only upon the protein and not the caloric intake (8).…”

mentioning

confidence: 99%

Effect of Weanling Malnutrition upon Hepatic Drug Metabolism

Eriksson¹,

Catz²,

Yaffe³

1975

Neonatology

View full text Add to dashboard Cite

Protein deficiency in post-suckling rats produced changes in the activity of hepatic drug-metabolizing enzymes. Significant decreases occurred in the N-demethylation of aminopyrine, in the azo-reduction of neoprontosil and in sulfokinase activity (using p-nitrophenylsulfate as S0₄ donor). An increase was recorded for the glucuronidation of p-nitrophenol and no changes were noted in the hydroxylations of hexobarbital and aniline. Refeeding the animals for 3 weeks returned all activities to control values. An exception was the azo-reductase activity indicating either a slower recovery or a permanent change.

show abstract

“…catabolism, cytotoxic drugs or other concurrent medication. Protein deficiency has been reported to raise the UDPglucuronyltransferase activity (Wood & Woodcock, 1977). Phenobarbitone and 3-methylcholanthrene are known inducers of this enzyme (Bock, 1974).…”

Section: Dose Interval Studymentioning

confidence: 99%

Morphine metabolism in cancer patients on increasing oral doses‐no evidence for autoinduction or dose‐dependence.

Säwe¹,

Svensson²,

Rane³

1983

Brit J Clinical Pharma

126

View full text Add to dashboard Cite

1 Four cancer patients with severe chronic pain were treated with oral morphine with increasing doses during 5-8 months. During this period the oral dose was increased 16-23-fold in each of the patients. Morphine, morphine-3-and morphine-6-glucuronide were determined with high performance liquid chromatography in plasma and urine during steady-state, at five or more occasions on different daily doses of morphine. 2 The trough concentrations of morphine and its metabolites were linearly related to the given dose. The relation between the levels of morphine and the two glucuronides was constant in the individual patient and independent of dose and duration of treatment. The average molar ratio between the areas under the plasma concentration-time curves (AUC) for morphine-3-glucuronide and morphine was 34.0 (range 23.0-46.9). The corresponding value for the ratio between morphine-6-glucuronide and morphine was 3.9 (range 2.7-5.6). 3 Our results show that the conjugation of morphine with glucuronic acid is proportional to the dose during long-term treatment with increasing doses, thus this metabolic pathway is not subject to auto-induction, even after very long periods of continuous treatment with high doses.

show abstract

Effects of dietary protein deficiency on the conjugation of foreign compounds in rat liver

Cited by 24 publications

References 12 publications

The effects of diet composition and ration on biotransformation enzymes and stress parameters in rainbow trout, Oncorhynchus mykiss

The effects of diet composition and ration on biotransformation enzymes and stress parameters in rainbow trout, Oncorhynchus mykiss

Effect of Weanling Malnutrition upon Hepatic Drug Metabolism

Morphine metabolism in cancer patients on increasing oral doses‐no evidence for autoinduction or dose‐dependence.

Contact Info

Product

Resources

About