Effects of dietary phytoestrogen exposure during perinatal period

Isoflavones are the most common phytoestrogens found in human diets. However, it is still not clear whether isoflavones have effects on the reproductive and the endocrine systems under normal dietary intake and overdose. The aim of this study was to determine how the most important isoflavones, genistein and daidzein, affect androgen and glucorticoid levels on male prepuberal rats. A hundred and seventy-five 30-day-old male Wistar rats were dosed orally by stomach tube every day for 35 days, with saline solution, low and high doses of genistein, daidzein and a mixture of both. Serum samples were analysed by an enzyme immunoassay for hormone determinations. In control group, there was a peak of testosterone (T) and dihydrotestosterone levels associated to the onset of puberty, at the third week. However, in low-dose groups, the same peak was found at the fourth week (p < 0.05), indicating a delay in the onset of puberty in these groups. Moreover, high doses groups serum androgen levels were significantly lower (p < 0.05) than the control group from the first week until fifth week. This fact was supported by a epididymal histological analysis that indicate in low doses there were several content of spermatozoa at fourth week and in high doses there were few content of spermatozoa. Besides, corticosterone levels followed the same pattern of androgens in all groups. We can conclude that oral administration of isoflavones in male rats decreased the secretion of androgens and glucocorticoids causing a delay in the onset of puberty and may cause physiological and developmental problems.

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“…; Herman‐Giddens ), and others claim there are no significant differences in T levels (Becker et al. ; Piotrowska et al. ).…”

Section: Discussionmentioning

confidence: 99%

“…; Becker et al. ; Sakai and Kogiso ). They have a structure similar to endogenous oestrogens affecting hormonal modulation (Sakai and Kogiso ) and so are considered as endocrine disruptors.…”

Section: Introductionmentioning

confidence: 97%

The Effects of Isoflavones on Androgens and Glucocorticoids During Puberty on Male Wistar Rats

Cáceres

Silván

Martínez-Fernández

et al. 2014

Reprod Domestic Animals

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“…Thus, various experimental studies performed on animal models have demonstrated some side-effects consecutive to an exposure to phytoestrogens during the perinatal period, i.e. in utero or just after birth [40][41][42][43][44][45][46]. These deleterious impacts include for instance anatomical and/or functional alterations of the reproductive and developmental functions, or troubles related to the cognitive and neurobehavioural spheres.…”

Section: Introductionmentioning

confidence: 99%

Multi-functional sample preparation procedure for measuring phytoestrogens in milk, cereals, and baby-food by liquid-chromatography tandem mass spectrometry with subsequent determination of their estrogenic activity using transcriptomic assay

Antignac

Gaudin-Hirret

Naegeli

et al. 2009

Analytica Chimica Acta

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“…Neuromuscular activities were evaluated by the following reflex actions: palmar prehension (beginning and end), surface righting, cliff avoidance, negative geotaxis, placing response and righting in air (Alder and Zbiden, 1977;Becker et al, 2005). All tests were carried out for 15 s and the measurement adopted considered the presence or absence of reflex and not the time taken to carry it out.…”

Section: Animals and Facilitiesmentioning

confidence: 99%

Postnatal development of pups from nursing rats treated with Gingko biloba

Faria

Borges

Peters

et al. 2007

Phytotherapy Research

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The Gingko biloba extract is contraindicated during pregnancy and lactation due to the lack of information about its effects on these reproductive phases. Previous studies have shown that G. biloba extract contains components with estrogenic and antiestrogenic activities, thus nursing dams treated with the extract of this plant could show reduction in milk production, resulting in malnutrition and poor development of pups. This work analyzes the postnatal development of pups, whose mothers were treated with G. biloba extract during the lactation period. Nursing Wistar rats received 3.5 mg/kg/day of G. biloba aqueous extract, corresponding to the highest human dose. Clinical signs of maternal toxicity were evaluated. The growth rate, viability, survival during treatment and lactation indices of the pups were calculated. The physical, motor and sensorial development of the pups was also evaluated. No maternal signs of toxicity were observed. As there were no biological differences between control and G. biloba treated pups, it is possible to assume that, in this experimental design, the administration of G. biloba aqueous extract to nursing rats during the lactation period seems to be devoid of toxic effect to mothers and to the physical, motor and sensory development of the pups.

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Effects of dietary phytoestrogen exposure during perinatal period

Cited by 13 publications

References 27 publications

The Effects of Isoflavones on Androgens and Glucocorticoids During Puberty on Male Wistar Rats

The Effects of Isoflavones on Androgens and Glucocorticoids During Puberty on Male Wistar Rats

Multi-functional sample preparation procedure for measuring phytoestrogens in milk, cereals, and baby-food by liquid-chromatography tandem mass spectrometry with subsequent determination of their estrogenic activity using transcriptomic assay

Postnatal development of pups from nursing rats treated with Gingko biloba

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