Effects of dietary PCBs and nonyl-phenol on immune function and CYP1A activity in channel catfish, Ictalurus punctatus

Rice, Charles D.; Roszell, L.E.; Banes, Michelle M.; Arnold, Robyn

doi:10.1016/s0141-1136(97)00121-9

Cited by 9 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 mg/l (mean¡S.D.). Because chlorinated biphenyls are lipophilic (Rice et al 1998 ;Quabius et al 2002), PCB 126 was administered via the food. After preparing a stock solution of 5 mg PCB 126 (AccuStandard Europe, Niederbipp, Switzerland) in 20 ml of ethanol (96 %, Roth, Karlsruhe, Germany), 1 .…”

Section: Exposurementioning

confidence: 99%

Individual and combined effects of cadmium and 3,3,4,4,5-pentachlorobiphenyl (PCB 126) on the humoral immune response in European eel (Anguilla anguilla) experimentally infected with larvae of Anguillicola crassus (Nematoda)

Sures

Knopf

2004

Parasitology

View full text Add to dashboard Cite

The individual and combined effects of cadmium (Cd) and 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on the antibody response of fish against metazoan parasites were tested. Eels experimentally infected with the swim bladder nematode Anguillicola crassus were exposed to sublethal concentrations of Cd and PCB 126. Cd was added to the water resulting in an effective concentration of 21.7 +/- 12.8 microg/l (mean +/- S.D.). PCB 126 was applied orally at a dose of approximately 100 ng PCB 126 per g body weight. At the end of the experiment, 76 days post-infection (p.i.), eels were found to be infected with 2-3 worms. Immunoblot analyses revealed that the body wall of adult worms was the most suitable crude antigen, and was subsequently used for an ELISA to evaluate the immune response of A. anguilla under various conditions. A significant increase of Anguillicola-specific antibodies in the peripheral blood was first detected 61 days p.i., indicating that it was not the invasive larvae but the adult worms which elicit the antibody response. The presence of Cd in the concentrations applied did not appear to modulate the production of antibodies. In contrast, the exposure to PCB 126 resulted in a complete suppression of the antibody response. A similar effect was also found for the combined exposure of the infected eels to Cd and PCB 126. A suppressed immune response, as demonstrated here, may be the reason why hosts exposed to environmental pollution became often much more easily infected than unexposed conspecifics.

show abstract

Section: Exposurementioning

confidence: 99%

Individual and combined effects of cadmium and 3,3,4,4,5-pentachlorobiphenyl (PCB 126) on the humoral immune response in European eel (Anguilla anguilla) experimentally infected with larvae of Anguillicola crassus (Nematoda)

Sures

Knopf

2004

Parasitology

View full text Add to dashboard Cite

show abstract

“…Long-term persistence of PCBs in aquatic environments poses significant threats to fish and human health, worldwide. Although PCBs have not been causally linked to declines in fish populations, PCB exposure is associated with acute and chronic immunosuppression [15][16][17] and can increase disease susceptibility [18,19], thereby reducing long-term population fitness and survival. Coplanar PCBs are thought to be the most toxic due to their affinity to the aryl hydrocarbon receptor (AhR), which results in dioxin-like effects via up-regulation of the CYP1A1 gene [20].…”

Section: Introductionmentioning

confidence: 99%

Tissue Distribution and Immunomodulation in Channel Catfish (Ictalurus punctatus) Following Dietary Exposure to Polychlorinated Biphenyl Aroclors and Food Deprivation

White

DeMario

Iwanowicz

et al. 2020

IJERPH

View full text Add to dashboard Cite

Although most countries banned manufacturing of polychlorinated biphenyls (PCBs) over 40 years ago, PCBs remain a global concern for wildlife and human health due to high bioaccumulation and biopersistance. PCB uptake mechanisms have been well studied in many taxa; however, less is known about depuration rates and how post-exposure diet can influence PCB concentrations and immune response in fish and wildlife populations. In a controlled laboratory environment, we investigated the influence of subchronic dietary exposure to two PCB Aroclors and food deprivation on tissue-specific concentrations of total PCBs and PCB homologs and innate immune function in channel catfish (Ictalurus punctatus). Overall, we found that the concentration of total PCBs and PCB homologs measured in whole body, fillet, and liver tissues declined more slowly in food-deprived fish, with slowest depuration observed in the liver. Additionally, fish that were exposed to PCBs had lower plasma cortisol concentrations, reduced phagocytic oxidative burst activity, and lower cytotoxic activity, suggesting that PCBs can influence stress and immune responses. However, for most measures of immune function, the effects of food deprivation had a larger effect on immune response than did PCB exposure. Taken together, these results suggest that short-term dietary exposure to PCBs can increase toxicity of consumable fish tissues for several weeks, and that PCB mixtures modulate immune and stress responses via multiple pathways. These results may inform development of human consumption advisories and can help predict and understand the influence of PCBs on fish health.

show abstract

Effect of nonylphenol on giant freshwater prawn (Macrobrachium rosenbergii) via oral treatment: Toxicity and messenger RNA expression of hemocyte genes

Sung

2009

Aquatic Toxicology

View full text Add to dashboard Cite

Effects of dietary PCBs and nonyl-phenol on immune function and CYP1A activity in channel catfish, Ictalurus punctatus

Cited by 9 publications

References 9 publications

Individual and combined effects of cadmium and 3,3,4,4,5-pentachlorobiphenyl (PCB 126) on the humoral immune response in European eel (Anguilla anguilla) experimentally infected with larvae of Anguillicola crassus (Nematoda)

Individual and combined effects of cadmium and 3,3,4,4,5-pentachlorobiphenyl (PCB 126) on the humoral immune response in European eel (Anguilla anguilla) experimentally infected with larvae of Anguillicola crassus (Nematoda)

Tissue Distribution and Immunomodulation in Channel Catfish (Ictalurus punctatus) Following Dietary Exposure to Polychlorinated Biphenyl Aroclors and Food Deprivation

Effect of nonylphenol on giant freshwater prawn (Macrobrachium rosenbergii) via oral treatment: Toxicity and messenger RNA expression of hemocyte genes

Contact Info

Product

Resources

About