Effects of Dietary Nucleotides on the Fatty Acid Composition of Erythrocyte Membrane Lipids in Term Infants

C, De-Lucchi; Pita, M L; Faus, María José; Molina, J. A.; Uauy, Ricardo; Gil, Ángel

doi:10.1097/00005176-198707000-00014

Cited by 74 publications

(42 citation statements)

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“…In this last study, at 2 weeks of age the reverse effect was noted with more nucleotide supplemented infants colonized with E. coli and a reduction in the counts of bifidobacteria. Dietary nucleotides only marginally influenced the essential fatty acid status of infants (Gil et al 1986b;DeLucchi et al 1987). Effects of dietary nucleotides on the gastrointestinal system and on hepatic growth and function have only been observed in animal studies (Uauy et al 1990;Bustamante et al 1994;Novak et al 1994).…”

Section: N U C L E O T I D E Smentioning

confidence: 99%

The Composition of Human Milk as a Model for the Design of Infant Formulas: Recent Findings and Possible Applications

Goedhart

Bindels

1994

Nutr. Res. Rev.

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Section: N U C L E O T I D E Smentioning

confidence: 99%

The Composition of Human Milk as a Model for the Design of Infant Formulas: Recent Findings and Possible Applications

Goedhart

Bindels

1994

Nutr. Res. Rev.

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“…Some randomized controlled trials (RCTs) involving formula-fed infants have reported beneficial effects of NT supplementation on various components of the immune system (Carver et al, 1991;Pickering et al, 1998;Buck et al, 2004;Schaller et al, 2004), the incidence of diarrhoea (Yau et al, 2003), intestinal microflora (Gil et al, 1986), growth of infants born small for gestational age (Cosgrove et al, 1996) and the synthesis of long-chain polyunsaturated fatty acids (LCPUFA) (DeLucchi et al, 1987). However, other RCTs have been unable to confirm the reported beneficial effects of NT supplementation (Balmer et al, 1994;Woltil et al, 1995;Yau et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary nucleotide supplementation on growth and immune function in term infants: a randomized controlled trial

Hawkes

Gibson

et al. 2005

Eur J Clin Nutr

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Objective: To examine the effect of nucleotide (NT)-supplemented cow's milk-based formula on growth and biochemical indices of immune function in healthy infants. Design: Randomized controlled trial (RCT) of formula-fed term infants allocated to control formula with an innate level of NT at 10 mg/l (n ¼ 102), or formula fortified with NT at 33.5 mg/l (n ¼ 98). A parallel group of 125 breastfed infants followed the same protocol as a reference. Outcome measures: Growth was assessed at enrolment, 7 weeks, 4 months and 7 months of age. Natural killer cell activity, cytokine production and lymphocyte subpopulations were assessed at 7 weeks of age. Antibody responses to diphtheria toxoid, tetanus toxoid and Haemophilus influenzae type b (Hib) immunizations were measured at 7 months of age. Results: NT supplementation did not influence the growth of formula fed infants or any markers of immunity measured at 7 weeks of age. Antibody responses to tetanus toxoid were higher in the NT-supplemented group (n ¼ 68) compared with the control group (n ¼ 70) at 7 months of age (median (5th, 95% percentile): 1.57(0.42, 3.43) vs 1.01(0.41, 4.66) IU/ml, Po0.03). A difference between treatments was seen in response to diphtheria toxoid but this effect disappeared when adjusted for hepatitis B immunization at birth. There was no effect of treatment on antibody responses to Hib immunization. Conclusions: Supplementation of formulas with NT at 33.5 mg/l resulted in a modest improvement in antibody response consistent with RCTs that used higher levels of NT supplementation. Whether this translates to clinical benefits in well-nourished infants requires further study.

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“…Nucleotides also have an effect on lipid metabolism, promoting increased polyunsaturated fatty acid concentrations in the erythrocytes and plasma of infants (13)(14)(15)(16) and increasing the bioavailability of dietary iron (17).…”

Section: Introductionmentioning

confidence: 99%

Use of nucleotides in weanling rats with diarrhea induced by a lactose overload: effect on the evolution of diarrhea and weight and on the histopathology of intestine, liver and spleen

Norton

Leite

Vieira

et al. 2001

Braz J Med Biol Res

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Until recently, dietary sources of nucleotides were thought not to be essential for good nutrition. Certain states with higher metabolic demands may require larger amounts that cannot be provided by endogenous production. The objective of the present study was to determine the action of nucleotides on the recovery from lactoseinduced diarrhea in weaned rats. Thirty-six weanling Fisher rats were divided into two groups. Group 1 received a standard diet and group 2 received a diet containing lactose in place of starch. On the 10th day, six animals per group were sacrificed for histopathological evaluation. The remaining animals were divided into two other subgroups, each with 6 animals, receiving a control diet, a control diet with nucleotides (0.05% adenosine monophosphate, 0.05% guanosine monophosphate, 0.05% cytidine monophosphate, 0.05% uridine monophosphate and 0.05% inosine monophosphate), a diet with lactose, and a diet with lactose and nucleotides. On the 32nd day of the experiment all animals were sacrificed. Animals with diarrhea weighed less than animals without diarrhea.

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Effects of Dietary Nucleotides on the Fatty Acid Composition of Erythrocyte Membrane Lipids in Term Infants

Cited by 74 publications

References 0 publications

The Composition of Human Milk as a Model for the Design of Infant Formulas: Recent Findings and Possible Applications

The Composition of Human Milk as a Model for the Design of Infant Formulas: Recent Findings and Possible Applications

Effect of dietary nucleotide supplementation on growth and immune function in term infants: a randomized controlled trial

Use of nucleotides in weanling rats with diarrhea induced by a lactose overload: effect on the evolution of diarrhea and weight and on the histopathology of intestine, liver and spleen

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