Effects of dietary l-arginine supplementation to gilts during early gestation on foetal survival, growth and myofiber formation

Bérard, Joël; Bee, Giuseppe

doi:10.1017/s1751731110000881

Cited by 82 publications

(62 citation statements)

References 30 publications

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“…These results are partially in agreement with the positive effect of Arg supplementation on prolificacy obtained in sows (1% Arg; +2 piglets; Mateo et al, 2007;0.8% Arg;+3.7 piglets;Berard and Bee, 2010) and rats (1.3% Arg; +3 rats; Zeng et al, 2008). In rats Arg supplementation increased the number of implantation sites and the litter size at birth, but in pigs these authors did not found any effect on the total number of piglets born per litter, but a great effect on the piglet survival rate at birth, effect that was not observed in this study.…”

Section: Discussionsupporting

confidence: 88%

“…There is no previous information about this lack of synergism between Arg and Gin on reproductive traits, although the single supplementation of these amino acids seem to exert different effects on the blood concentration of the other one. The single supplementation of Arg decreased the plasmatic Gin concentration in pregnant gilts (Mateo et al, 2007;Berard and Bee, 2010), whereas the single Gin supplementation increased the plasmatic Arg concentration (Wu et al, 2011). In pregnant rats, the single supplementation of Arg, exerted the opposite effect, and increased the serum Gin concentration (Zeng et al, 2008).…”

Section: Discussionmentioning

confidence: 98%

“…This rise coincides with the time where the development of the placenta is faster (Wu et al, 2005) and suggests that both nitric oxide and polyamines are key regulators of angiogenesis and embryogenesis as well as placental and fetal growth . Arginine supplementation during early gestation (around 8 g/ kg and 14-28 d pregnancy) in gilts improved fetal survival (Berard and Bee, 2010) whereas its supplementation (10 g/kg) from day 30 of pregnancy to parturition increased the number of piglets born alive and their live weight (Mateo et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Effect of dietary supplementation with arginine and glutamine on the performance of rabbit does and their litters during the first three lactations

Delgado

Abad-Guamán

Mata

et al. 2017

Animal Feed Science and Technology

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The aim of this work was to study whether the dietary supplementation with arginine (Arg) and glutamine (Gin) or the combination of both influence the digestibility, body composition, and reproductive performance of rabbit does during the first three parturitions. A Control diet containing 29.8 g nitrogen (N), 313 g aNDFom per kg DM and 1.85 g digestible N/MJ digestible energy (DN/DE) was formulated, and another 3 diets were obtained by adding (gAg) 4 Arg, 4 Gin and a mixture of 4 Arg and 4 of Gin to the Control diet. Eighty nulliparous rabbit does were randomly assigned to the diets (20/diet) before the first insemination. After each parturition litter size were homogenized within each treatment and does inseminated lid later. Chemical composition and energy content of rabbit does and their performance, litter growth and milk production were measured between birth and weaning (25 d) along three parturitions. Amino acid supplementation increased the DN content (P = 0.015) and tended to increase the DN/DE ratio compared to Control group {P = 0.077) leading to an increase of digestible N intake during lactation (P = 0.004). In this period, Gin group had a higher DE intake compared to Control and Arg + Gin groups {P = 0.038). Total number kits born per litter tended to increase in rabbit does supplemented with Arg and Gin, compared to Control and Arg + Gin groups {P = 0.095), but no effect of treatments on the number of weaned rabbits was observed (P = 0.15). Single supplementation of Arg and Gin increased the weight of the litters at 20 and 25 d respect to Control and Arg + Gin groups {P < 0.021). Amino acid supplementation did not affect the milk production (P = 0.16), although it was positively correlated with the DE and DN intake (P < 0.001). There were no significant effects of treatments on body weight, chemical composition and energy content of rabbit does, but does supplemented with Arg or Gin tended to have a higher body energy content at the third insemination and at weaning than those from Control and Arg + Gin groups (P < 0.099). Amino acid supplementation did not modify the replacement rate of rabbit does. In conclusion, the single supplementation of Arg and Gin had a positive effect on the weight of litters at weaning and litter size at birth, but no additive effect was observed for the combined supplementation of Arg and Gin.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Effect of dietary supplementation with arginine and glutamine on the performance of rabbit does and their litters during the first three lactations

Delgado

Abad-Guamán

Mata

et al. 2017

Animal Feed Science and Technology

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“…Dietary 1% L-arginine-HCl supplementation could markedly increase the live-born piglets by 2 per litter . Daily supplementation of 26 g L-arginine to gilts from d14 to d28 of gestation enhanced fetal survival and positively affected the primary phase of myofiber formation (Bérard & Bee 2010). Besides, dietary arginine supplementation could decrease maternal abortion rate and neonatal mortality in mice with porcine circovirus type 2 infection (Ren et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Arginine enhances embryo implantation in rats through PI3K/PKB/mTOR/NO signaling pathway during early pregnancy

Zeng¹,

Mao²,

Huang³

et al. 2013

Reproduction

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Our previous study has demonstrated that dietary arginine supplementation during early pregnancy enhanced embryo implantation in rats. However, the mechanism was not clear. The objective of this study was to determine the mechanism that arginine enhanced embryo implantation during early pregnancy. Rats were fed the basal diets supplemented with 1.3% (wt:wt) L-arginine-HCl or 2.2% (wt:wt) L-alanine (isonitrogenous control) once pregnancy. On d4 of pregnancy, rats were given intrauterine injection of L-NG-nitro arginine methyl ester (L-NAME, nitric oxide synthase inhibitor), a-difluoromethylornithine (DFMO, polyamine synthesis inhibitor), wortmannin (PI3K inhibitor), or rapamycin (mTOR inhibitor). On d7 of pregnancy, rats were killed. Intrauterine injection of L-NAME decreased the implantation sites, while dietary arginine supplementation increased the implantation sites. Intrauterine injection of DFMO decreased the pregnancy rate, which was reversed by dietary arginine supplementation. Intrauterine injection of rapamycin or wortmannin inhibited embryo implantation. However, dietary arginine supplementation did not reverse this inhibition. Western blot analysis revealed that the expression of uterine p-PKB and p-S6K1 was greater in rats fed the arginine-supplemented diet in the presence of L-NAME treatment compared with rats fed the control diet. In the presence of DFMO treatment, the expression of uterine iNOS and eNOS was significantly enhanced in the arginine group compared with the control group. Similarly, intrauterine injection of wortmannin or rapamycin decreased the expression of uterine iNOS and eNOS, which was enhanced by dietary arginine supplementation. These data indicated that dietary arginine supplementation during early pregnancy could enhance embryo implantation through stimulation of PI3K/PKB/mTOR/NO signaling pathway.

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“…Third, as compared with control gilts, dietary supplementation with 0.4 or 0.8% L-arginine between days 14 and 25 of gestation increased placental weights 21-34% and number of viable fetuses per litter by approximately 2 . Fourth, supplementation with 1% arginine between days 14 and 28 of gestation increased the number of fetuses per litter by 3.7 on day 70 of gestation in superovulated gilts (Bérard and Bee, 2010). Fifth, supplementing 1% arginine to gilts beginning on day 17 of gestation for 16 days increased the number of live-born piglets per litter by 1.2 (De Blasio et al, 2009).…”

Section: Argininementioning

confidence: 99%

Pregnancy recognition signals in mammals: the roles of interferons and estrogens

Bazer

Johnson

2017

Anim Reprod

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Reproduction is a highly complex biological process requiring a dialogue between the developing conceptus (embryo-fetus and associated placental membranes) and maternal uterus which must be established during the peri-implantation period for pregnancy recognition signaling and regulation of gene expression by uterine epithelial and stromal cells. The uterus provide a microenvironment in which molecules secreted by uterine epithelia or transported into the uterine lumen represent histotroph or the secretome required for growth and development of the conceptus and receptivity of the uterus to implantation by the conceptus. Pregnancy recognition signaling as related to sustaining the functional lifespan of the corpora lutea (CL) which produce progesterone; the hormone of pregnancy essential for uterine functions that support implantation and placentation required for successful outcomes of pregnancy. It is within the periimplantation period that most embryonic deaths occur in mammals due to deficiencies attributed to uterine functions or failure of the conceptus to develop appropriately, signal pregnancy recognition and/or undergo implantation and placentation. The endocrine status of the pregnant female and her nutritional status are critical for successful establishment and maintenance of pregnancy. The challenge is to understand the complexity of key mechanisms that are characteristic of successful reproduction and to use that knowledge to enhance fertility and reproductive health of animals including nonhuman primates. It is important to translate knowledge gained from studies of animals to address issues of fertility and reproductive health in humans.

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Effects of dietary l-arginine supplementation to gilts during early gestation on foetal survival, growth and myofiber formation

Cited by 82 publications

References 30 publications

Effect of dietary supplementation with arginine and glutamine on the performance of rabbit does and their litters during the first three lactations

Effect of dietary supplementation with arginine and glutamine on the performance of rabbit does and their litters during the first three lactations

Arginine enhances embryo implantation in rats through PI3K/PKB/mTOR/NO signaling pathway during early pregnancy

Pregnancy recognition signals in mammals: the roles of interferons and estrogens

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