Effects of dietary fructose on plasma lipids in healthy subjects

Bantle, John P.; Raatz, Susan K.; Thomas, William; Georgopoulos, Angeliki

doi:10.1093/ajcn/72.5.1128

Cited by 271 publications

(197 citation statements)

References 42 publications

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“…Regarding concentrations of serum triglycerides, the results are controversial; in some studies dietary fiber has been shown to have no effect on the concentration of serum triglycerides (Vuksan et al, 1999(Vuksan et al, , 2000, whereas in some other studies a decreasing effect of dietary fiber has been reported (Chandalia et al, 2000). The most commonly reported negative effect of fructose on serum lipid profile has been the increased concentration of serum triglycerides ( Bantle et al, 2000). This effect was not seen in the present study.…”

Section: Discussioncontrasting

confidence: 71%

Impact of sugar beet pectin and polydextrose on fasting and postprandial glycemia and fasting concentrations of serum total and lipoprotein lipids in middle-aged subjects with abnormal glucose metabolism

Schwab

Louheranta

Törrönen³

et al. 2006

Eur J Clin Nutr

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Objective: To examine the effects of sugar beet pectin (SBP) and polydextrose (PDX) on fasting plasma glucose concentration, serum lipid profile and postprandial glycemia in middle-aged subjects with abnormal glucose metabolism. Design: A placebo-controlled, randomized, parallel double-blinded study. Subjects and setting: Subjects were recruited via newspaper announcements. Seventy subjects were recruited of which 66 completed the study. Intervention: The intervention period lasted for 12 weeks during which the subjects consumed a drink enriched with either SBP (n ¼ 22) or PDX (n ¼ 22) or without fiber enrichment (control group, n ¼ 22). The daily dose of the drinks was 4 dl. The subjects were also given nutrition counseling. Postprandial glycemia was examined in 24 subjects (n ¼ 8 in each group) at 0 and 12 weeks after a standardized breakfast. Results: Fasting plasma glucose concentration did not change in the SBP and PDX groups, whereas it increased in the control group (P ¼ 0.007). On the contrary, the glycosylated hemoglobin A1 c increased marginally but significantly (Pp0.05) in the intervention groups without a change in the control group. In postprandial glycemia, no differences between the groups were found. In both the SBP and PDX groups, fasting serum High-density lipoprotein (HDL)-cholesterol concentration increased (Pp0.05) without a change in the control group. Total to HDL-cholesterol ratio decreased in all groups (Pp0.05). Conclusions: It was found that SBP and PDX do not have positive effects on fasting or postprandial plasma glucose concentrations or serum lipid profile in subjects with abnormal glucose metabolism. Sponsorship:

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Section: Discussioncontrasting

confidence: 71%

Impact of sugar beet pectin and polydextrose on fasting and postprandial glycemia and fasting concentrations of serum total and lipoprotein lipids in middle-aged subjects with abnormal glucose metabolism

Schwab

Louheranta

Törrönen³

et al. 2006

Eur J Clin Nutr

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“…This is E20 times lower than mean intakes in the United States, in which approximately 9% of daily energy is derived from fructose. 135 High intakes of fructose have been implicated in the development of dyslipidemia and obesity. 131,136 High intakes of dietary fructose induce hyperlipidemia in rodents, 132 but studies on the effect of fructose intake on plasma lipids in adult humans are equivocal.…”

Section: Ldl Particle Sizementioning

confidence: 99%

“…Several have shown an effect of a high fructose intake on plasma lipids, particularly increased triglyceride concentrations, 137,138 but others have not. 135,139 The dietary determinants of LDL particle size in adults and children are uncertain. Several studies have shown that short-term high carbohydrate diets lead to a reduction in LDL particle size, [140][141][142] but they investigated only total carbohydrate intake and not specific types of carbohydrates.…”

Section: Ldl Particle Sizementioning

confidence: 99%

Dietary determinants of subclinical inflammation, dyslipidemia and components of the metabolic syndrome in overweight children: a review

Zimmermann

Aeberli

2008

Int J Obes

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Objective: To review and summarize the dietary determinants of the metabolic syndrome, subclinical inflammation and dyslipidemia in overweight children. Design: Review of the current literature, focusing on pediatric studies. Participants: Normal weight, overweight, or obese children and adolescents. Results: There is a growing literature on the metabolic effects of excess body fat during childhood. However, few pediatric studies have examined the dietary determinants of obesity-related metabolic disturbances. From the available data, it appears that dietary factors are not only important environmental determinants of adiposity, but also may affect components of the metabolic syndrome and modulate the actions of adipokines. Dietary total fat and saturated fat are associated with insulin resistance and high blood pressure, as well as obesity-related inflammation. In contrast to studies in adults, resistin and adiponectin do not appear to be closely linked to insulin resistance or dyslipidemia in childhood. However, circulating leptin and retinol-binding protein (RBP) 4 correlate well with obesity, central obesity and the metabolic syndrome in children. Intakes of antioxidant vitamins tend to be low in obese children and may be predictors of subclinical inflammation. Higher fructose intake from sweets and sweetened drinks in overweight children has been linked to decreased low-density lipoprotein (LDL) particle size. Conclusions: Dietary interventions aimed at reducing intakes of total fat, saturated fat and free fructose, whereas increasing antioxidant vitamin intake may be beneficial in overweight children. More research on the relationships between dietary factors and the metabolic changes of pediatric obesity may help to identify the dietary changes to reduce health risks. International Journal of Obesity (2008) 32, S11-S18; doi:10. 1038/ijo.2008.202 Keywords: child; metabolic syndrome; diet; inflammation; adipokine IntroductionIn both industrialized and non-industrialized countries, the prevalence of pediatric obesity is increasing. 1 Dietary factors are environmental determinants of adiposity, as well as components of the metabolic syndrome, and may modulate the actions of adipokines. Better understanding of the relationships between dietary factors and the metabolic changes of pediatric obesity may help to identify the dietary changes to reduce health risks. Hypertension, insulin resistance, resistin and adiponectinPediatric obesity is an important risk factor for adult hypertension and type 2 diabetes, and approximately one third of obese children are hypertensive and/or hyperinsulinemic. 2,3 The adipocyte-derived hormones resistin, adiponectin and leptin may play a role in the development of hypertension and/or insulin resistance. 4-7 Among children, inverse associations of adiponectin or resistin with body mass index (BMI) and insulin resistance have been reported, 8 but not all studies agree. 9 Studies on diet in childhood hypertension have mainly focused on sodium or calcium intake, rather than macr...

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“…Disparate findings have been reported in this regard, with some studies showing positive associations between higher fructose consumption and plasma lipids (11,12) and blood pressure (13) and others showing no relationship (14,15). In children with diabetes, one small, short-term feeding trial was done showing no significant effect of high dietary fructose feeding on plasma lipids (16).…”

Section: Introductionmentioning

confidence: 89%

Fructose Intake and Cardiovascular Risk Factors in Youth with Type 1 Diabetes: The SEARCH for Diabetes in Youth Study

Couch¹,

Crandell²,

Shah³

et al. 2011

Journal of the American Dietetic Association

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Aims-High consumption of dietary fructose has been shown to contribute to dyslipidemia and elevated blood pressure in adults, but there are few data in youth, particularly those at greater risk of cardiovascular disease (CVD). The aim of this study was to examine the association between fructose intake and CVD risk factors in a diverse population of youth with type 1diabetes (T1D).Methods-This was a cross-sectional analysis of data from the SEARCH for Diabetes in Youth study, including 2085 youth ages 10-22 years with T1D, of which 22% were racial/ethnic © 2013 Elsevier Ireland Ltd. All rights reserved.Corresponding author address: Sarah C. Couch, Ph.D., RD. 3202 Eden Avenue, French Building East, Room 363B, University of Cincinnati Medical Center, Cincinnati, OH 45267-0394; Telephone: 513-558-7504; Fax: 513-558-7500; Sarah.Couch@uc.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Financial disclosures: none to report Conflict of Interest Statement:The authors declare that they have no conflict of interest. HHS Public Access Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript minority and 50% were female. A semi-quantitative food frequency questionnaire was used to assess intake.Results-Median daily fructose consumption was 7.9% of total calories. Fructose intake was positively associated with triglycerides (p<.01), but not with total cholesterol, LDL-cholesterol, HDL-cholesterol, or blood pressure after adjustment for physical activity and socio-demographic, clinical, and dietary covariates. An increase in fructose intake of 22 grams (equivalent to a 12 oz. can of soda) was associated with a 23% higher odds of borderline/ high versus low triglycerides (p<.005).Conclusion-These data suggest that children with T1D should moderate their intake of fructose, particularly those with borderline or high triglycerides.

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Effects of dietary fructose on plasma lipids in healthy subjects

Abstract: Dietary fructose was associated with increased fasting and postprandial plasma triacylglycerol concentrations in men. Diets high in added fructose may be undesirable, particularly for men. Glucose may be a suitable replacement sugar.

Cited by 271 publications

References 42 publications

Impact of sugar beet pectin and polydextrose on fasting and postprandial glycemia and fasting concentrations of serum total and lipoprotein lipids in middle-aged subjects with abnormal glucose metabolism

Impact of sugar beet pectin and polydextrose on fasting and postprandial glycemia and fasting concentrations of serum total and lipoprotein lipids in middle-aged subjects with abnormal glucose metabolism

Dietary determinants of subclinical inflammation, dyslipidemia and components of the metabolic syndrome in overweight children: a review

Fructose Intake and Cardiovascular Risk Factors in Youth with Type 1 Diabetes: The SEARCH for Diabetes in Youth Study

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