Effects of dietary fibers with high water-binding capacity and swelling capacity on gastrointestinal functions, food intake and body weight in male rats

Tan, Chunqing; Wei, Hong; Xitao, Zhao; Xu, Chong; Peng, Jian

doi:10.1080/16546628.2017.1308118

Cited by 42 publications

(19 citation statements)

References 45 publications

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“…The physiological responses to viscous and fermented dietary fibers eventually promote and prolong satiety. In a previous study, we found that supplementing rat feed with 2% CSF reduced food intake by promoting satiety [30,31]. In the present study as well, CSF significantly promoted satiety and increased weight loss when HFD was replaced with the normal feed.…”

Section: Discussionsupporting

confidence: 80%

“…Studies show that the mixture of hydrophilic colloid and pre-gelatinized starch can synergistically improve viscosity, water binding capacity, and stability [28,29]. In our previous works, combining guar gum, a strongly hydrophilic straight-chain β-1-4-mannose, with pre-gelatinized waxy maize starch resulted in a combined soluble fiber (CSF) with physicochemical properties similar to that of konjac flour [30,31]. In the present study, we determined the effects of this CSF on HFD-fed obese mice, and explored the relationship between dietary CSF consumption, intestinal microbiota, and metabolic status.…”

Section: Introductionmentioning

confidence: 99%

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Combined Soluble Fiber-Mediated Intestinal Microbiota Improve Insulin Sensitivity of Obese Mice

Liu

Gao

et al. 2020

Nutrients

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Dietary fiber, an important regulator of intestinal microbiota, is a promising tool for preventing obesity and related metabolic disorders. However, the functional links between dietary fiber, intestinal microbiota, and obesity phenotype are still not fully understood. Combined soluble fiber (CSF) is a synthetic mixture of polysaccharides and displays high viscosity, water-binding capacity, swelling capacity, and fermentability. We found that supplementing high-fat diet (HFD) with 6% CSF significantly improved the insulin sensitivity of obese mice without affecting their body weight. Replacing the HFD with normal chow basal diet (NCD), the presence of CSF in the feed significantly enhanced satiety, decreased energy intake, promoted weight and fat loss, and augmented insulin sensitivity. CSF also improved the intestinal morphological integrity, attenuated systemic inflammation, promoted intestinal microbiota homeostasis, and stabilized the production of short-chain fatty acids (SCFAs) that was perturbed during HFD-induced obesity, and these stabilizing effects were more prominent when the basal diet was switched to NCD. The enrichment of bacteria of the S24-7 family and Allobaculum genus increased markedly in the intestine following 6% CSF supplementation- and correlated with decreased adiposity and insulin resistance. Five bacterial genera that were decreased by CSF, including Oscillospira, unclassified Lachonospitaceae, unclassified Clostridiales, unclassified Desulfovibrionaceae, and unclassified Ruminococcae, were subjected to co-occurrence network analysis and were positively correlated to adiposity and insulin resistance, indicating a key role in the microbial response to CSF. Thus, CSF has a potential to promote insulin sensitivity and even reduce obesity via beneficial regulation of the gut microecosystem.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Combined Soluble Fiber-Mediated Intestinal Microbiota Improve Insulin Sensitivity of Obese Mice

Liu

Gao

et al. 2020

Nutrients

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“…2016; Tan et al . 2017); here, we also found that CF lowered the ADFI of pregnant rats. Indeed, to some extent, CF could play a probiotic role in the gut as a soluble dietary fibre.…”

Section: Discussionsupporting

confidence: 79%

Chicory fibre improves reproductive performance of pregnant rats involving in altering intestinal microbiota composition

Huang

Zong

et al. 2020

J Appl Microbiol

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Aim Chicory fibre (CF) is rich in fructan, which always functions as a quality dietary fibre source during mammalian pregnancy; however, its effect on reproductive performance remains unclear. Methods and Results 40 pregnant SD rats were randomly allotted to receive one of four diets: basal diet (control group), basal diet + 5% CF, basal diet + 10% CF, and basal diet + 15% CF, respectively. We found that CF significantly increased the number born alive and total litter birth weight (P < 0·05), increased the expression of intestinal tight junction proteins, mucins and antimicrobial peptides, accompanied by the increase of villi height and the decrease of crypts depth of pregnant SD rats (P < 0·05). We also observed that CF markedly increased the acetic acid, propanoic acid, butyric acid and total SCFAs concentrations in caecum contents and promoted the expression of SCFAs‐related receptors (P < 0·05). Notably, rats fed CF increased the relative abundance of Bacteroidetes (P < 0·001), decreased the relative abundance of Firmicutes and Proteobacteria, while markedly lowered the Firmicutes/ Bacteroidetes ratio (F/B ratio) (P < 0·05). Intriguingly, the number born alive and total litter birth weight were positively correlated with some probiotics and negatively correlated with other harmful bacteria by Pearson correlation analysis. Conclusion Collectively, CF can enhance intestinal barrier function and maintain intestinal health, and may improve reproductive performance by altering intestinal microbiota composition. Significance and Impact of the Study Adding suitable dietary fibre to the diet can improve the reproductive performance of sows. Indeed, there exist various problems in the application of traditional dietary fibres, including high insoluble fibre content and anti‐nutritional factor level, and mycotoxin contamination. This study demonstrates that dietary CF supplementation improves reproductive performance and intestinal health. Thus, CF can be applied in pregnancy animals as a new dietary fibre additive in animal husbandry.

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“…For example, acetate has been shown to be an antiinflammatory metabolite to maintain gut homeostasis, and butyrate is beneficial for modulating intestinal permeability (18,19). Our previous results showed that the combined soluble fiber materials (pregelatinized waxy maize starch plus guar gum) had a high water-binding capacity and swelling capacity (20). Pregelatinized waxy maize starch, a fermentation-resistant starch composed mainly of highly branched amorphous amylopectin, has many specific food attributes (21).…”

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confidence: 99%

Maternal Soluble Fiber Diet during Pregnancy Changes the Intestinal Microbiota, Improves Growth Performance, and Reduces Intestinal Permeability in Piglets

Cheng

Wei

et al. 2018

Appl Environ Microbiol

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Increasing evidence suggests that maternal diet during pregnancy modifies offspring's microbiota composition and intestinal development in a long-term manner. However, the effects of maternal soluble fiber diet during pregnancy on growth traits and the developing intestine are still underexplored. Sows were allocated to either control or 2.0% pregelatinized waxy maize starch plus guar gum (SF) dietary treatment during gestation. Growth performance, diarrhea incidence, gut microbiota composition and metabolism, and gut permeability and inflammation status of 14-day-old suckling piglets were analysed. The maternal SF diet improved growth rate but decreased diarrhea incidence of piglets. Next-generation sequencing analysis revealed that the intestinal microbiota composition was altered by a maternal SF diet. The fecal and plasma levels of acetate and butyrate were also increased. Furthermore, a maternal SF diet reduced the levels of plasma zonulin and fecal lipocalin-2 but increased the plasma concentrations of interleukin 10 (IL-10) and transforming growth factor β (TGF-β). Additionally, the increased relative abundances of in SF piglets were positively correlated with growth rate while the decreased was positively correlated with fecal lipocalin-2. Our data reveal that a maternal SF diet during pregnancy has remarkable effects on offspring's growth traits, intestinal permeability and inflammation may via modulating the composition and metabolism of gut microbiota. Although the direct effects of dietary soluble fiber on gut microbiota have been extensively studied, the more indirect effects of maternal nutrition during pregnancy independently on the development of the intestine are until now largely unexplored. Our data show that a maternal soluble fiber diet during pregnancy is independently associated with changes in intestinal microbiota composition and metabolism of suckling piglets. These findings have direct implications for refining dietary recommendations in pregnancy. Moreover, a maternal soluble fiber diet reduces intestinal permeability, prevents intestinal inflammation and excessive systemic immune response of suckling piglets. Therefore, the suckling piglets' resistance to disease was enhanced, diarrhea was reduced and weight gain was raised. Additionally, the changes of gut microbiota in response to a maternal soluble fiber diet may also direct correlated with the offspring's growth and gut development.

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Effects of dietary fibers with high water-binding capacity and swelling capacity on gastrointestinal functions, food intake and body weight in male rats

Cited by 42 publications

References 45 publications

Combined Soluble Fiber-Mediated Intestinal Microbiota Improve Insulin Sensitivity of Obese Mice

Combined Soluble Fiber-Mediated Intestinal Microbiota Improve Insulin Sensitivity of Obese Mice

Chicory fibre improves reproductive performance of pregnant rats involving in altering intestinal microbiota composition

Maternal Soluble Fiber Diet during Pregnancy Changes the Intestinal Microbiota, Improves Growth Performance, and Reduces Intestinal Permeability in Piglets

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