Effects of dietary fibers, micronutrients, and phytonutrients on gut microbiome: a review

Beane, Kaleigh E.; Redding, Mersady C.; Wang, Xiaofan; Pan, Jeong Hoon; Le, Brandy; Cicalo, Cara; Jeon, Suwon; Kim, Young Jun; Lee, Jin Hyup; Shin, Eui‐Cheol; Li, Ying; Zhao, Jiangchao; Kim, Jae Kyeom

doi:10.1186/s13765-021-00605-6

Cited by 17 publications

(16 citation statements)

References 132 publications

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“…The results of our study emphasize the importance of a high fiber diet for individuals who have genetic risk of vitamin D deficiency. The role of dietary fiber in relation to the vitamin D-GRS and BMI is not clear; however, both fiber and vitamin D are involved in the health and regulation of the gut microbiome [64]. Dietary fiber is known to have helpful effects on weight management due to their bulking effect and fermentation by the gut microbiota [65,66].…”

Section: Discussionmentioning

confidence: 99%

“…As for vitamin D, studies have demonstrated that vitamin D and its receptor, VDR, can regulate and influence gut microbiota [71,72]. Vitamin D has immune-modulatory properties such as inhibiting inflammation and infections and hence might be important in modifying gut microbiota [64]. As both fiber and vitamin D have anti-inflammatory properties, and both are potential modifiers of the gut microbiome, therefore, our gene-fiber intake interaction on BMI could be possibly a result of the influence of microbiome modulation brought about by reduced dietary fiber intake in participants with an increased genetic susceptibility to vitamin D deficiency.…”

Section: Discussionmentioning

confidence: 99%

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Interactions between Vitamin D Genetic Risk and Dietary Factors on Metabolic Disease-Related Outcomes in Ghanaian Adults

et al. 2022

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The Ghanaian population is experiencing an upsurge in obesity and type 2 diabetes (T2D) due to rapid urbanization. Besides dietary factors, vitamin D-related genetic determinants have also been shown to contribute to the development of obesity and T2D. Hence, we aimed to examine the interactions between dietary factors and vitamin D-related genetic variants on obesity and T2D related outcomes in a Ghanaian population. Three hundred and two healthy Ghanaian adults (25–60 years old) from Oforikrom, Municipality in Kumasi, Ghana were randomly recruited and had genetic tests, dietary consumption analysis, and anthropometric and biochemical measurements of glucose, HbA1c, insulin, cholesterol, and triglycerides taken. A significant interaction was identified between vitamin D-GRS and fiber intake (g/day) on BMI (pinteraction = 0.020) where those who were consuming low fiber (≤16.19 g/d) and carrying more than two risk alleles for vitamin D deficiency (p = 0.01) had a significantly higher BMI. In addition, an interaction between vitamin D-GRS and fat intake (g/day) on HbA1c (total fat, pinteraction = 0.029) was found, where participants who had a lower total fat intake (≤36.5 g/d), despite carrying more than two risk alleles, had significantly lower HbA1c (p = 0.049). In summary, our study has identified novel gene–diet interactions of vitamin D-GRS with dietary fiber and fat intakes on metabolic traits in Ghanaian adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Interactions between Vitamin D Genetic Risk and Dietary Factors on Metabolic Disease-Related Outcomes in Ghanaian Adults

et al. 2022

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“…Poor diet and/or impaired bile acid processes-features of NAFLD-drive micronutrient malabsorption of essential vitamins and minerals. 57,172,173 Fat-soluble vitamins, in particular, require appropriate bile acid metabolism. Bile salts facilitate the absorption of dietary fats through the intestinal lining.…”

Section: Mnd and The Gut Microbiomementioning

confidence: 99%

Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective

et al. 2022

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“…Of note is that the interaction between gut microbiome and minerals is bidirectional meaning that while the microbiota can affect the absorption of minerals, its composition is also influenced by changes in the level of trace minerals. For instance, selenium status strongly correlates with a higher diversity of gut microbiome [ 68 ]. Therefore, it is not unreasonable to propose that LithoLexal ® Joint as a source of major and trace biominerals may provoke observable improvements in the dysbiotic microbiome of patients with osteoarthritis.…”

Section: Litholexal ® Joint a Natural Dmat For The Management Of Osteoarthritismentioning

confidence: 99%

Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal® Joint—A Review

Eriksen

Lech

Nakama

et al. 2021

Clinics and Practice

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Modern advances in molecular medicine have led to the reframing of osteoarthritis as a metabolically active, inflammatory disorder with local and systemic contributing factors. According to the ‘inflammatory theory’ of osteoarthritis, immune response to an initial damage is the key trigger that leads to progressive joint destruction. Several intertwined pathways are known to induce and govern articular inflammation, cartilage matrix degradation, and subchondral bone changes. Effective treatments capable of halting or delaying the progression of osteoarthritis remain elusive. As a result, supplements such as glucosamine and chondroitin sulphate are commonly used despite the lack of scientific consensus. A novel option for adjunctive therapy of osteoarthritis is LithoLexal® Joint, a marine-derived, mineral-rich extract, that exhibited significant efficacy in clinical trials. LithoLexal® has a lattice microstructure containing a combination of bioactive rare minerals. Mechanistic research suggests that this novel treatment possesses various potential disease-modifying properties, such as suppression of nuclear factor kappa-B, interleukin 1β, tumor necrosis factor α, and cyclooxygenase-2. Accordingly, LithoLexal® Joint can be considered a disease-modifying adjunctive therapy (DMAT). LithoLexal® Joint monotherapy in patients with knee osteoarthritis has significantly improved symptoms and walking ability with higher efficacy than glucosamine. Preliminary evidence also suggests that LithoLexal® Joint may allow clinicians to reduce the dose of nonsteroidal anti-inflammatory drugs in osteoarthritic patients by up to 50%. In conclusion, the multi-mineral complex, LithoLexal® Joint, appears to be a promising candidate for DMAT of osteoarthritis, which may narrow the existing gap in clinical practice.

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Effects of dietary fibers, micronutrients, and phytonutrients on gut microbiome: a review

Cited by 17 publications

References 132 publications

Interactions between Vitamin D Genetic Risk and Dietary Factors on Metabolic Disease-Related Outcomes in Ghanaian Adults

Interactions between Vitamin D Genetic Risk and Dietary Factors on Metabolic Disease-Related Outcomes in Ghanaian Adults

Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective

Disease-Modifying Adjunctive Therapy (DMAT) in Osteoarthritis—The Biological Effects of a Multi-Mineral Complex, LithoLexal® Joint—A Review

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