Effects of dietary copper, molybdenum and sulfur on biliary copper and zinc excretion in Simmental and Angus cattle

Gooneratne, S. R.; Christensen, David A.; Bailey, Jeremy V.; Symonds, H.W.

doi:10.4141/cjas94-043

Cited by 40 publications

(41 citation statements)

References 31 publications

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“…This was further investigated by Gooneratne et al (1994), who found that Simmental cattle had a much greater biliary excretion of Cu. In the current study, we did not investigate differences in Cu excretion.…”

Section: Discussionmentioning

confidence: 99%

A disparate trace element metabolism in zebu (Bos indicus) and crossbred (Bos indicus × Bos taurus) cattle in response to a copper-deficient diet1

Dermauw

Cuyper

Duchateau

et al. 2014

Journal of Animal Science

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Copper deficiency is a commonly diagnosed problem in cattle around the globe. In Jimma, Ethiopia, 8 zebu (Bos indicus) and 8 zebu × Holstein Friesian cross (Bos taurus × Bos indicus) heifers were used in an 11-wk study to investigate breed type differences and effects of Cu deficiency on concentrations of trace elements in plasma and edible tissues as well as mRNA expression of Cu-related genes. Heifers were fed a grass diet (6.4 ± 0.2 [SEM] mg Cu/kg DM) supplemented with 1 mg Mo/kg DM in wk 1 to 4 and 2 mg Mo/ kg DM in wk 5 to 11, with blood samples collected every 2 wk and tissue collection postmortem. Plasma, liver, kidney, and semitendinosus and cardiac muscle were analyzed for Zn, Cu, Fe, Se, Mo, Co, and Mn. Expression of mRNA Cu-related genes was measured in aorta (lysyl oxidase [LOX] ) as well as the Se-related glutathione peroxidase 1 (Gpx1). Zebu cattle maintained initial plasma Cu concentrations just below the threshold value for deficiency, whereas crossbred cattle gradually became severely Cu deficient over time (P < 0.001). In contrast, plasma Zn and Co were greater in zebu cattle at the onset of the trial but became similar to crossbred cattle towards the end of the trial (P < 0.001). Liver Cu (P = 0.002) and Fe (P 0.001), kidney Se (P < 0.001), and kidney and cardiac muscle Co (P 0.001) concentrations were greater in zebu than in crossbred cattle. Increased hepatic mRNA expression of the Cu regulatory genes Atp7b, Ctr1 (P = 0.02), CCS (P = 0.03), and Cox17 (P = 0.009) and Cu-related Sod1 (P = 0.001) as well as the Se-related Gpx1 (P 0.001) were greater in zebu than in crossbred cattle. However, duodenal mRNA expression of DAO (P = 0.8) and Mt1a (P = 0.2) and aortic expression of LOX (P = 0.8) were not different. Both the differences in Cu status indices (plasma and liver concentrations) and hepatic mRNA expression of Cu regulatory genes point to the possibility of a more efficient use of dietary Cu in B. indicus as compared to B. taurus × B. indicus cattle resulting in greater sensitivity to Cu deficiency in B. taurus crossbred cattle. initial plasma Cu concentrations just below the threshold value for deficiency, whereas crossbred cattle gradually became severely Cu deficient over time (P < 0.001). In contrast, plasma Zn and Co were greater in zebu cattle at the onset of the trial but became similar to crossbred cattle towards the end of the trial (P < 0.001). Liver Cu (P = 0.002) and Fe (P ≤ 0.001), kidney Se (P < 0.001), and kidney and cardiac muscle Co (P ≤ 0.001) concentrations were greater in zebu than in crossbred cattle. Increased hepatic mRNA expression of the Cu regulatory genes Atp7b, Ctr1 (P = 0.02), CCS (P = 0.03), and Cox17 (P = 0.009) and Cu-related Sod1 (P = 0.001) as well as the Se-related Gpx1 (P ≤ 0.001) were greater in zebu than in crossbred cattle. However, duodenal mRNA expression of DAO (P = 0.8) and Mt1a (P = 0.2) and aortic expression of LOX (P = 0.8) were not different. Both the differences in Cu status indices (plasma and liver concentrations) and hepatic mRNA ...

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Section: Discussionmentioning

confidence: 99%

A disparate trace element metabolism in zebu (Bos indicus) and crossbred (Bos indicus × Bos taurus) cattle in response to a copper-deficient diet1

Dermauw

Cuyper

Duchateau

et al. 2014

Journal of Animal Science

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“…A few studies have examined the associations between age, body condition and pregnancy status on Cu concentrations in small numbers of beef cattle (Smart and Christensen 1985;Gooneratne and Christensen 1989;Littledike et al 1995). However, the effect of an animal's physiologic parameters and Mn, Mo and Se concentrations has not been reported in the literature, and the effect of age on vitamin A and vitamin E has only been reported for dairy animals (Katsoulos et al 2005).…”

mentioning

confidence: 99%

“…High iron concentrations are also common, particularly in deep well water (Gould et al 2002;Olkowski 2009). High dietary levels of sulphate, Mo, and iron adversely affect the absorption, utilization, and excretion of Cu in ruminants, potentially resulting in secondary Cu deficiency (Suttle 1991;Gooneratne et al 1994).…”

mentioning

confidence: 99%

Serum micronutrient concentrations in beef cows before and after the summer grazing season

Weyer¹,

Hendrick²,

Waldner³

2010

Can. J. Anim. Sci.

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Van De Weyer, L. M., Hendrick, S. and Waldner, C. L. 2010. Serum micronutrient concentrations in beef cows before and after the summer grazing season. Can. J. Anim. Sci. 90: 563Á574. Serum concentrations of Cu, Mn, Mo, Se, vitamin A, and vitamin E were measured at the start and at the end of the summer grazing season in an observational field study of 791 commercial beef cows from 40 cow-calf herds from five community pastures. Copper and vitamin A were higher in the fall (PB0.001), and Mo (P B0.001) and selenium (PB0.001) were lower in the fall compared with the spring. Cows aged 10Á14 yr had lower concentrations of vitamin A (P B0.001) and vitamin E (spring: P00.010; fall: PB0.001) than cows aged 4Á9 yr. Cows with thin pre-breeding body condition scores were more likely to have lower pre-breeding Cu concentrations than cows that were not thin (P00.044). Cows that were thin at the end of the grazing season were more likely to have lower vitamin A concentrations at this time than cows that were not thin (P00.033). Trace mineral supplementation given before calving was associated with higher spring concentrations of Cu (P 00.007). Season of sample collection and the physiological status of the animals should be considered when interpreting the serum micronutrient status of beef cows and developing supplementation programs.

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“…The breed of the dam is an important determinant of lamb Cu status at birth and in early life (Wiener et al 1984), with lambs from Welsh mountain ewes having higher blood and liver Cu concentrations than those from Scottish blackface sheep. Genetic differences in Cu metabolism may also exist in cattle (Gooneratne et al 1994). In dogs, the Bedlington terrier and several other breeds accumulate Cu in the liver throughout life (Thornburg 2000).…”

Section: Discussionmentioning

confidence: 99%

Liver copper kinetics in Thoroughbred foals at pasture from birth to 160 days of age

Gee

Morel

Mogg

et al. 2004

New Zealand Journal of Agricultural Research

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Effects of dietary copper, molybdenum and sulfur on biliary copper and zinc excretion in Simmental and Angus cattle

Cited by 40 publications

References 31 publications

A disparate trace element metabolism in zebu (Bos indicus) and crossbred (Bos indicus × Bos taurus) cattle in response to a copper-deficient diet1

A disparate trace element metabolism in zebu (Bos indicus) and crossbred (Bos indicus × Bos taurus) cattle in response to a copper-deficient diet1

Serum micronutrient concentrations in beef cows before and after the summer grazing season

Liver copper kinetics in Thoroughbred foals at pasture from birth to 160 days of age

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